Therapeutic class: gastroenteropancreatic Hepatology
active ingredients: Sachet A: Macrogol 3350 , sodium sulphate (E514) , sodium chloride , potassium chloride (E508) , Packet B: Ascorbic acid (E300) , sodium ascorbate (E301)
what is moviprep ?
This medication is an osmotic laxative in the form of an oral solution.
It is indicated for intestinal lavage prior to any examination requiring a clean bowel (for example: endoscopic or radiological exploration).
PRESENTATION (S) AVAILABLE FOR MOVIPREP
1 box containing 2 bags each with 1 low density polyethylene (LDPE) aluminum powder A sachet (s) of 112 g and 1 low density polyethylene (LDPE) aluminum powder B sachet (s) of 11 g
|Active substance (s)||for a sachet: potassium chloride (1.015 g), sodium chloride (2.691 g), anhydrous sodium sulfate (7.5 g), macrogol 3350 (100.00 g), ascorbic (acid) (4.7 g) , sodium ascorbate (5,900 g)|
|Pharmaceutical form||powder and powder for oral solution|
|Route (s) of administration||oral|
|Selling price||€ 10.30|
|Social security reimbursement rate||65%|
|Laboratory (s)||NORGINE PHARMA|
|Conditions of issue||restricted prescription drug|
what is moviprep medication used for and indications?
Moviprep is a solution, administered orally, intended for washing the intestines prior to any examination requiring a clean bowel (for example: endoscopic or radiological exploration) in adults.
Adults and the elderly:
- The preparation consists of drinking two liters of Moviprep solution. It is also recommended to drink, in addition, a liter of clear liquid including water, clear soup, fruit juice without pulp, non-alcoholic drink, tea and / or coffee without milk.
- To obtain a liter of Moviprep consists in dissolving together 1 sachet A and 1 sachet B in one liter of water.
- This reconstituted solution should be drunk over a period of one to two hours.
- Repeat the same operation to obtain a 2 nd liter of Moviprep.
- This preparation can be taken in the following ways:
- or twice with one liter of Moviprep ingested the night before the examination and one liter ingested early in the morning on the day of the examination.
- or all at once with the two liters of Moviprep ingested the night before the examination.
- At least an hour must pass between taking the last glass of liquid (Moviprep or drink) and the examination.
- No solid food should be ingested from the start of preparation until the end of the examination.
- No studies have been performed in the pediatric population.
- Moviprep is therefore not recommended for people under the age of 18.
Do not use in patients with a history or suspicion of:
- Hypersensitivity to the active substances or to any of the excipients listed in the Composition section,
Gastrointestinal obstruction or perforation
- Disorders of gastric emptying (gastroparesis),Ileus,
- Phenylketonuria (due to the presence of aspartame),
- Glucose-6-phosphate dehydrogenase deficiency (due to the presence of ascorbate),
- Toxic megacolon, in severe forms of inflammation of the intestinal tract, including Crohn’s disease and ulcerative colitis.
- Do not use in unconscious patients.
HOW TO TAKE moviprep?
Always take this medicine exactly as your doctor tells you. Check with your doctor or pharmacist if you are not sure.
The recommended dose is 2 liters of solution to be prepared as follows:
- The box contains two transparent bags and each bag contains two sachets: one sachet A and one sachet B. Each pair of sachets (sachet A and sachet B) is to be dissolved in water in order to obtain one liter of solution. The assembly will thus make it possible to reconstitute two liters of MOVIPREP solution.
- Before taking MOVIPREP, read the following instructions carefully.
You must know :
- When to take MOVIPREP?
- How to prepare MOVIPREP?
- How to take MOVIPREP?
- What you should expect with MOVIPREP
When to take MOVIPREP?
Always take this medicine as described in this leaflet or as your doctor has told you. Check with your doctor if you are unsure. Your treatment with MOVIPREP must be completely finished before the test.
This preparation can be taken either twice or as a single dose as described below:
For exams that require you to fall asleep (under general anesthesia):
- In two installments: one liter of MOVIPREP ingested the night before the exam and one liter of MOVIPREP ingested early in the morning on the day of the exam. Make sure that you stop taking MOVIPREP and all other clear liquids at least two hours before the start of the test.
- 2. As a single dose: two liters of MOVIPREP ingested the night before the exam or two liters of MOVIPREP on the morning of the exam. Make sure that you stop taking MOVIPREP and all other clear liquids at least two hours before the start of the test.
For exams that do not require you to fall asleep (without general anesthesia):
- In two installments: one liter of MOVIPREP ingested the night before the exam and one liter of MOVIPREP ingested early in the morning on the day of the exam. Make sure that you stop taking MOVIPREP and any other clear liquid at least one hour before the start of the test.
- 2. As a single dose: two liters of MOVIPREP ingested the night before the exam or two liters of MOVIPREP on the morning of the exam. Make sure that you stop taking MOVIPREP at least two hours before the start of the test. Make sure that you stop taking any other clear fluids at least one hour before the start of the test.
- Important: Do not eat solid food from the moment you take MOVIPREP and until the end of the test .
How to prepare MOVIPREP?
- Open a transparent bag and remove the sachets A and B.
- Pour both 1 sachet A and 1 sachet B in a graduated container which can hold 1 liter.
- Make up with water to the 1 L mark in the container. Then mix until the powder is completely dissolved (this can take up to 5 minutes).
How to take MOVIPREP?
- This reconstituted solution should be drunk over a period of one to two hours. It is advisable to drink a glass of the solution every 10 or 15 minutes.
- When the time comes, prepare and drink the second liter of MOVIPREP using sachets A and B from the remaining bag.
- While taking treatment, it is recommended that you drink an extra liter of clear liquid to prevent feeling thirsty or dehydrated. Water, clear soup, fruit juice without pulp, soft drinks, tea and / or coffee without milk can be consumed. Clear fluids can be taken no later than two hours before the test under general anesthesia and up to one hour before the test without general anesthesia.
What to expect with MOVIPREP
- When you start drinking the preparation, it is important that you stay near the toilet. At some point, you will begin to pass more or less liquid stools. This is normal and indicates that the preparation is working. The evacuation will stop shortly after you have finished drinking the preparation.
- If you follow these instructions, your bowel will be clean and it will help the test to be successful. Allow sufficient time to elapse between your last glass of fluid and the time of the appointment at the examination center.
If you have any further questions about the use of this medicine, contact your doctor or pharmacist.
If you stop taking MOVIPREP, powder for oral solution
how does moviprep work?
- Macrogol 3350 remains unchanged throughout its journey through the intestine. It is virtually unabsorbed. The potentially absorbable macrogol fraction is excreted in the urine.
- Ascorbic acid is mainly absorbed from the small intestine by a saturable sodium-dependent active transport mechanism. There is an inverse relationship between the dose ingested and the percentage of the dose absorbed. For ingested oral doses of 30 to 180 mg, approximately 70 to 85% of the dose is absorbed. After ingestion of a dose of ascorbic acid of up to 12 g, only 2 g is absorbed.
- Furthermore, after ingestion of high doses of ascorbic acid and as soon as the plasma concentrations exceed 14 mg / liter, the latter is mainly excreted in the urine, in unchanged form.
HOW TO STORE moviprep?
- Keep this medication out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the outer packaging after EXP. The expiration dates of the different sachets may differ from each other. The expiration date refers to the last day of that month.
- Store at a temperature not exceeding 25 ° C.
- After reconstitution, store in a closed container for 24 hours at a temperature not exceeding 25 ° C or in a refrigerator (between 2 ° and 8 ° C).
- Any solution not used within 24 hours of reconstitution should be discarded.
- Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.
moviprep Side Effects
Like all medicines, MOVIPREP powder for oral solution in sachet can cause side effects, although not everybody gets them.
Diarrhea is an expected effect when using MOVIPREP.
Very frequently (affecting more than 1 in 10 patients who took the treatment) the following side effects have been reported: abdominal pain, abdominal distension, fatigue, general malaise (feeling of not feeling well), anal pain, and nausea.
Frequently (affecting less than 1 in 10 people but more than 1 in 100 people who took the treatment) the following side effects have been reported: feeling of hunger, trouble sleeping, dizziness, headache, vomiting, indigestion, feeling thirsty and chills.
Uncommonly (affecting less than 1 in 100 people but more than 1 in 1000 patients who took the treatment) the following side effects have been reported: discomfort, difficulty in swallowing and changes in liver function parameters.
The following side effects have sometimes been reported but their frequency is unknown: flatulence (gas), transient increase in blood pressure, gagging (up to vomiting), very low sodium levels in the blood may occur. complicate with seizures, and changes in blood electrolyte levels such as decrease in bicarbonates, increase or decrease in calcium, increase or decrease in chlorine, decrease in phosphate.
The levels of potassium and sodium in the blood may also decrease, especially in patients treated with medicines which affect kidney function, used to treat heart disease (ACE inhibitors and diuretics).
These reactions usually only occur while taking treatment. If these persist, consult your doctor.
Allergic reactions have also been reported.
If you experience any of the following side effects, stop taking MOVIPREP and contact your doctor immediately. You should not restart taking MOVIPREP until you have consulted your doctor.
- Rash or itching.
- Swelling of the face, ankles or other parts of your body.
- Extreme fatigue.
- Shortness of breath.
If you do not experience an evacuation within 6 hours of taking MOVIPREP for the first time, stop taking it and contact your doctor immediately.
If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.
Keep out of the reach and sight of children.
Oral treatments should not be taken within 1 hour of ingestion of Moviprep as they may not be absorbed due to the bowel movement induced by the preparation.
For drugs with a narrow therapeutic window or a short half-life, the efficacy may be particularly affected.
Drive and use machines
Warnings and Precautions
Diarrhea is an expected effect of using Moviprep.
If you are fragile or have severe clinical failure, you should pay attention to the list of possible side effects. Contact your doctor or pharmacist if you are concerned.
Before taking Moviprep, you should also tell your doctor if you have the following disorders:
- Swallowing disorders (need to thicken liquids in order to swallow them) or tendency to regurgitation.
- Severe renal failure.
- Heart failure.
- Severe flare-ups of inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
- Moviprep should not be administered without medical supervision to a patient with impaired vigilance.
PREGNANCY & BREAST-FEEDING & FERTILITY
- There are no data from the use of Moviprep during pregnancy. Moviprep should only be used if the doctor considers it essential.
Feeding with milk
- There are no data from the use of Moviprep during breast-feeding. Moviprep should only be used if the doctor considers it essential.
- There are no data regarding the effect of Moviprep on fertility.
What happens if I overdose from moviprep?
If you take more MOVIPREP powder for oral solution than you should
- Immediately consult your doctor or pharmacist.
- If you take more MOVIPREP than needed, you may get excessive diarrhea which can lead to dehydration. Drink a large amount of liquid, especially fruit juice. If you are worried, contact your doctor or pharmacist.
What should I do if I miss a dose?
- If you forget to take MOVIPREP, take the prescribed dose as soon as you remember. If you have let several hours pass, contact your doctor or pharmacist for advice.
- If you are taking MOVIPREP twice, it is important that you have finished taking all of the MOVIPREP preparation at least one hour before the test (without general anesthesia) or two hours before the test (with general anesthesia).
- If you take MOVIPREP all at once on the morning of the test, it is important that you have finished taking all of the MOVIPREP preparation at least two hours before the test.
What is Forms and Composition ?
|SHAPES and PRESENTATIONS|
- Powder for oral solution (white to yellowish for sachet A; white to light brown for sachet B): Box of 2 transparent bags (i.e. 1 treatment) each containing one sachet A and one sachet B.
|The ingredients of Moviprep are contained in two separate sachets.|
|Sachet A contains the following active substances:|
|Macrogol 3350||100 g|
|Anhydrous sodium sulfate||7.5 g|
|Sodium chloride||2.691 g|
|Potassium chloride||1.015 g|
- Excipients: aspartame (E951), acesulfame potassium (E950), lemon flavor (maltodextrin, citral, lemon essential oil, lime essential oil, xanthan gum, vitamin E).
- Excipient with known effect: each sachet A contains 0.233 g of aspartame (E951).
|Sachet B contains the following active substances:|
|Ascorbic acid||4.7 g|
|Sodium ascorbate||5.9 g|
|The electrolyte concentration, after dissolving the two sachets in one liter of water, is as follows:|
|Sodium||181.6 mmol / L|
|(of which at most 56.2 mmol is absorbable)|
|Sulfate||52.8 mmol / L|
|Chloride||59.8 mmol / L|
|Potassium||14.2 mmol / L|
|Ascorbate||29.8 mmol / L|
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