marga tablet to suck Uses, Dosage, Side Effects, Precautions & Warnings

MARGA, sucking tablet, box of 48
80 / 100

Generic drug of the Therapeutic class: Gastro-Entero-Hepatology
Active ingredients: Hydrated aluminum oxide , Magnesium hydroxide (E527) , Calcium carbonate

what is marga tablets used for and indication?

This medication is indicated for the symptomatic treatment of pain associated with eso-gastro-duodenal disorders.

marga tablets Dosage

6 tablets to be sucked per 24 hours after meals and / or when feeling unwell.

marga Contraindications

  • Related to magnesium: severe renal failure.

How To Take marga ?

Administration mode

Oral route.

how does marga work?

Pharmacotherapeutic group: ANTIACID (A: digestive system and metabolism), ATC code: A02AD01.

In vitro study of a unit dose according to the VATIER method:

  • Total antacid capacity (titration at pH 1): 7.2 mmoles of H +.

Action mechanism 

  •  Neutralizing power (pH rise): 20%
  • Buffering capacity (maintaining around a fixed pH): 80% at pH 1.8 – 0.8
  • Theoretical protection capacity:
    • From pH 1 to pH 2: 4.4 mmoles of H + / tablet
    • From pH 1 to pH 3: 5.5 mmol H + / tablet
  • Theoretical speed of release of the antacid power: 80-90% at 30 min.

marga Side Effects

The side effects reported with MARGA, tablet are listed below by System Organ Class (SOC) and by frequency. Frequencies are defined as: very rare (≥1 / 100,000 and <1/10000) and frequency not known (cannot be estimated from the available data).

List of side effects in tabular form:

Adverse reactions related to the presence of aluminum hydroxide

SOC (MedDRA) Frequency Undesirable effect
Metabolism and nutrition disorders Indeterminate Phosphorus depletion (in case of prolonged or high dose use)

Adverse effects related to the presence of magnesium

SOC (MedDRA) Frequency Undesirable effect
Metabolism and nutrition disorders Very rare Hypermagnesemia (seen after prolonged administration of magnesium hydroxide to patients with renal impairment)
Gastrointestinal disorders Indeterminate Abdominal pain Diarrhea (at high dose)

marga Interactions

Antacids (aluminum salts, calcium and magnesium) interact with certain other drugs taken by mouth.

There is a decrease in the digestive absorption of drugs administered simultaneously.

As a precaution, antacids should be taken away from other drugs (for example 2 hours).

Combinations subject to precautions for use

  • · Indomethacin (NSAID): Decreased digestive absorption of indomethacin, administered simultaneously with antacids.
  • · Phosphorus (intake): Decreased digestive absorption of phosphorus.
  • · Acetylsalicylic acid (and by extrapolation: other salicylates): Decreased digestive absorption of salicylates administered simultaneously with antacids.
  • · H2 antihistamines (Cimetidine and Ranitidine): Decreased digestive absorption of cimetidine, administered simultaneously with antacids.
  • · Beta-blockers: Decreased digestive absorption of beta-blockers administered simultaneously with antacids.
  • · Chlorpromazine: Decreased digestive absorption of chlorpromazine, administered simultaneously with antacids.
  • · Cyclines (oral route): Decreased digestive absorption of cyclins.
  • · Diflunisal: Decreased digestive absorption of diflunisal, administered simultaneously with antacids.
  • · Isoniazid: Decreased digestive absorption of isoniazid, administered simultaneously with antacids.

Fluoroquinolones (ciprofloxacin, norfloxacin, pefloxacin): Decreased digestive absorption of fluoroquinolones.

Association to be taken into account

  • · Alkalinization of urine secondary to administration of magnesium hydroxide may affect the excretion of certain drugs; an increased excretion of salicylates was thus observed.

Effects on ability to Drive and use machines

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Warnings and Precautions

Special warnings

  • This drug contains sorbitol. Its use is not recommended in patients with fructose intolerance (a rare hereditary disease).
  • This medicine contains sucrose. Its use is not recommended in patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase / isomaltase deficiency.

Pediatric population:

  • In young children, the use of magnesium hydroxide can cause hypermagnesemia, especially if they have kidney failure or dehydration.

Precautions for use

  • In case of a diet limited in carbohydrates: take into account a sucrose intake of 1.17 g per intake.
  • In patients with kidney failure and chronic dialysis patients, take into account the content of aluminum and magnesium salts. Prolonged exposure to large doses may lead to a risk of encephalopathy, dementia, microcytic anemia or worsening of osteomalacia induced by dialysis.
  • Calcium: (20 mg per tablet) In high doses or in prolonged use, possible occurrence of hypercalcemia with risk of nephrolithiasis and renal failure.



  • There are no reliable data on teratogenesis in animals.
  • Clinically, no particular malformative or foetotoxic effect has appeared to date. However, the monitoring of pregnancies exposed to this drug is insufficient to exclude any risk.
  • Therefore, the use of this medicine should only be considered during pregnancy if necessary.
  • Take into account the presence of aluminum or magnesium ions likely to affect transit.
  • – Magnesium hydroxide salts can cause diarrhea,
  • · Aluminum salts are the cause of constipation which can be added to that, classic of pregnancy.
  • Avoid prolonged and high doses of this medication.

Feeding with milk

  • Breast-feeding can be continued during this treatment.

What happens if I overdose from marga ?

Oral overdose of magnesium does not usually cause toxic reactions in normal kidney function. Magnesium poisoning, however, may develop in renal failure (see section Warnings and precautions for use, Precautions for use).

The toxic effects depend on the level of magnesium in the blood and the signs are as follows:

Decrease in blood pressure

  • Nausea, vomiting
  • Drowsiness, decreased reflexes, muscle fatigability, neuromuscular paralysis,
  • Bradycardia, ECG abnormalities


  • In the most severe cases, respiratory paralysis, coma, kidney failure or cardiac arrest may occur,

Anuric syndrome.

  • Treatment of magnesium overdose: The effects of hypermagnesemia may be antagonized by intravenous administration of calcium gluconate. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking marga ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

Appearance and shape

  • Pharmaceutical form: tablet to suck
  • 48 tablets in blister packs (PVC / Aluminum).


Active ingredient Tablet to suck
Hydrated aluminum oxide 100 mg *
Magnesium hydroxide 60 mg *
Calcium carbonate 50 mg *

* per unit dose

Active ingredients: Aluminum oxide hydrated magnesium hydroxide calcium carbonate

Excipients with known effects ?

  • Sorbitol
Other excipients: Magnesium stearate, Maltodextrin, Sucrose, Mint flavor: Peppermint essential oil, Natural menthol, Maltodextrin, Vegetable gum


Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

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