DIFFU K 600 mg Capsule Uses, Dosage, Side Effects & Precautions
What is Diffu K used for AND indication?
- This medicine is indicated for the treatment and prevention of potassium deficiency.
- Preventive treatment: 2 to 3 capsules per day (ie 16 to 24 mmol (mEq) / day).
- Curative treatment: 5 to 12 capsules per day (40 to 96 mmol (mEq) / day).
- Situation that can lead to hyperkalaemia
- Renal failure
- Addisonian syndrome
- Uncontrolled diabetes
- Congenital myotonia
Hyperkalaemia or any situation that could lead to hyperkalaemia, in particular: renal failure, Addisonian syndromes, uncontrolled diabetes (because of metabolic acidosis), congenital myotonia, concomitant treatment with a potassium-sparing diuretic alone or in combination (except under strict control of serum potassium) .
How it works Diffu-k?
- Biologically, hypokalemia less than 3.6 mmol / l (mEq) indicates potassium deficiency.
This deficiency can be of origin:
odigestive: diarrhea, vomiting, stimulant laxatives,
- o renal: by increased urinary excretion in tubular disease, congenital or during treatment with sali-diuretics, corticosteroids or amphotericin B (IV), by excessive consumption of alkali or derivatives of licorice,
- o endocrine: primary hyperaldosteronism (aetiological treatment).
- This potassium deficiency, when it is symptomatic, results in: muscular fatigue, pseudo-paralysis, cramps and ECG changes, disorders of repolarization and ventricular hyperexcitability.
- Its contribution corrects the metabolic alkalosis often associated with hypokalemia.
- · Dispersion of microcapsules and slow dissolution of KCl reduce the risk of ulcerogenic action of potassium chloride.
Diffu-k Side Effects
- Hyperkalemia (with risk of sudden death): this is to be prevented by the control of serum potassium .
- In high doses, possibility of peptic ulceration.Some cases of hail ulceration have been reported with some solid oral forms. The ulcerogenic risk is reduced due to the dispersion and slow dissolution of KCl microcapsules.
- Certain drugs or therapeutic classes may promote the occurrence of hyperkalemia: potassium salts, potassium diuretics, angiotensin-converting enzyme inhibitors, angiotensin II antagonists, nonsteroidal anti-inflammatory drugs, heparins (low molecular weight or unfractionated), immunosuppressants such as ciclosporin or tacrolimus, trimethoprim.
- The combination of these drugs increases the risk of hyperkalemia. This risk is particularly important with potassium-sparing diuretics, especially when they are combined with one another or with potassium salts, whereas the combination of an ACE inhibitor and an NSAID, for example, is safer as soon as possible. the moment that the recommended precautions are implemented.
To know the risks and stress levels specific to hyperkalemic drugs, it is necessary to refer to the interactions specific to each substance.
However, some substances, such as trimethoprim, are not the subject of specific interactions with regard to this risk. Nevertheless, they can act as contributing factors when combined with other drugs already mentioned in this cap.
Contraindicated combinations (see Contraindications section )
Potassium sparing diuretics (alone or in combination): amiloride, canrenone, spironolactone, triamterene
Potentially lethal hyperkalemia, especially in renal failure (addition of hyperkalemic effects). Contraindicated unless there is hypokalemia
Associations advised against (see section Warnings and precautions for use )
ACE inhibitor and angiotensin II receptor antagonists
Potentially lethal hyperkalemia, especially during renal failure (addition of hyperkalaemic effects). Avoid this association unless there is prior hypokalemia.
- Hyperkalemia potentially lethal, especially during renal failure (addition of hyperkalemic effects).
- Avoid this association unless there is prior hypokalemia.
Warnings and Precautions
Precautions for use
- Control of serum potassium before and during treatment.
- Use with caution in the elderly.
Taking this medicine with ciclosporin, tacrolimus, conversion enzyme inhibitors or langiotensin II antagonists is not recommended
Drive and use machines
- Not applicable.
PREGNANCY / BREAST FEEDING / FERTILITY
- Given the available data, use in pregnant or breastfeeding women is possible.
What should I do if I miss a dose?
If you forget to take DIFFU K, capsule:
- Do not take a double dose to make up for the dose you forgot to take.
What happens if I overdose from Diffu-k ?
If you take more DIFFU K, capsule than you should:
- Overdose exposes to the risk of hyperkalemia. Notify a doctor immediately.
What is Forms and Composition?
What does DIFFU K, capsule contain?
- Microencapsulated potassium chloride *: 600.00 mg
- (Corresponding to 8 mEq of potassium)
- for one capsule
- * Composition of microencapsulated potassium: potassium chloride (80 to 90 percent), ethylcellulose (20 to 10 percent), intermediate microencapsulation adjuvants: cyclohexane, polyethylene C10.
- Magnesium stearate, sodium lauryl sulphate.
Composition of the capsule shell:
- Head (opaque yellow): gelatin, titanium dioxide, yellow iron oxide.
- Body (opaque white): gelatin, titanium dioxide.
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- For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.
- It treats possible side effects and drug interactions that require attention and its effect on continuous use.
- The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.