The text below is about the active substance benzalkonium chloride.
mechanism of action
- Benzalkonium chloride is a quaternary ammonium that has been used for many years as a surfactant and antiseptic / disinfectant. It is known for its bactericidal properties at low concentrations (usually between 0.1 and 0.2%) on a broad spectrum of Gram-positive and Gram-negative bacteria.
- this Drug eliminates (5 log decrease) Staphylococcus aureus and beta-hemolytic streptococci (eg Streptococcus pyogenes ) in 1 minute, as well as Pseudomonas aeruginosa in 5 minutes.
- also has spermicidal activity. The active substance causes the membrane of the sperm to rupture. Physiologically, the destruction of the sperm occurs in two stages: first destruction of the flagellum, then bursting of the head. There is no modification of the saprophytic flora: the Döderlein bacillus is respected.
benzalkonium chloride uses
By the cutaneous route, benzalkonium chloride is used in the management of antisepsis of wounds.
By the nasal route, it is used in the management of nasopharyngitis.
Via the vagina, it is used in the management of contraception.
In combination with tuaminoheptane and acetylcysteine, it is used in the management of nasopharyngitis.
In combination with chlorhexidine , it is used in the management of antisepsis for wounds and skin disorders.
In combination with chlorhexidine and benzyl alcohol, it is used in the management of antisepsis for wounds, skin disorders and in surgery.
In combination with lidocaine , it is used in the management of oral disorders.
In combination with phenylephrine , it is used in the management of:
Medicines containing the active substance alone (6)
Medicines containing the active substance in combination (9)