heat-sealed film (s) polyethylene aluminum PAM-ethylene (SURLYN) of 10 tablet (s)
heat-sealed film (s) polyethylene aluminum PAM-ethylene paper (SURLYN) of 20 tablet (s)
heat-sealed film (s) polyethylene aluminum PAM-ethylene paper (SURLYN) of 30 tablet (s)
heat-sealed film (s) polyethylene aluminum PAM-ethylene paper (SURLYN) of 40 tablet (s)

FEATURE	DESCRIPTION
Pharmaceutical class	not communicated
Active substance (s)	for one tablet: acetylsalicylic acid (0.267 g), caffeine (0.040 g), paracetamol (0.133 g)
General medicine	no
Pharmaceutical form	effervescent tablet
Route (s) of administration	oral
Selling price	unregulated price
Social security reimbursement rate	0%
Laboratory (s)	Laboratory (ies) manufacturer Actron
Conditions of issue	available without prescription

actron tablet Dosage

FOR ADULTS ONLY

The catches should be spaced at least 4 hours apart.
- Adult: As an indication: 1 tablet to be renewed if necessary after 4 hours. In case of more intense pain, 2 tablets per dose. Do not exceed the dose of 7 tablets per day. The maximum daily dosage of aspirin and paracetamol is 3 g.
- Elderly subject: As an indication: 1 tablet to be renewed if necessary after 4 hours. In case of more intense pain, 2 tablets per dose. Do not exceed the dose of 5 tablets per day. The maximum daily dosage of aspirin and paracetamol is 2 g.

actron tablet Contraindications

Never take ACTRON, effervescent tablet in the following cases:

child under 15 due to the presence of caffeine.
from the 6 ^th month of pregnancy,
allergy to aspirin, paracetamol or a related drug (especially non-steroidal anti-inflammatory drugs),
severe liver disease,
ulcer of the stomach or duodenum in progress,
haemorrhagic disease or risk of haemorrhage,
in case of treatment by:
- methotrexate (doses greater than 15 mg per week),
- oral anticoagulants when aspirin is prescribed in high doses (greater than or equal to 3 g per day).

This medication SHOULD NOT BE USED GENERALLY, unless your doctor advises otherwise,

in case of breastfeeding,
in case of treatment by:
- oral anticoagulants (for aspirin doses of less than 3 g per day),
- other non-steroidal anti-inflammatory drugs (for high doses of aspirin or greater than or equal to 3 g per day),
- injectable heparins,
- uricosurics (gout medications)
- ticlopidine,
- enoxacin.

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

How To Take Actron ?

Administration mode

ORAL

Drink immediately after complete dissolution of the effervescent tablet in a glass of water, sweetened or not, milk or fruit juice.

Frequency of administration

The catches distributed throughout the day make it possible to avoid peaks of fever or pain. They should be spaced at least 4 hours apart.
In the event of serious kidney disease (severe renal failure), the catches should be spaced at least 8 hours apart.
Due to the presence of caffeine, avoid taking this medication at the end of the day.

Duration of the treatment

Do not exceed 3 days of treatment in case of fever, nor 5 days of treatment in case of pain without the advice of your doctor.
DO NOT USE ON AN EXTENDED BASIS WITHOUT MEDICAL ADVICE.

How To Store Actron effervescent ?

Keep this medication out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton. The expiration date refers to the last day of that month.
Store at a temperature not exceeding 25 ° C.
Do not throw away any medicine via wastewater or household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

Actron Side Effects

Like all medicines, ACTRON, effervescent tablet can cause side effects, although not everybody gets them:

You should STOP YOUR TREATMENT IMMEDIATELY and notify your doctor in the following cases:

allergic reactions such as rash, asthma attack, angioedema (facial hives with difficulty breathing),
haemorrhage (discharge of blood through the mouth or in the stool, stool color black). This is all the more frequent the higher the dosage used.
ringing in the ears, sensation of hearing loss, headache: these usually indicate an overdose of aspirin.

Notify your doctor in case of abdominal pain, nosebleeds, gums.

Possibility of excitement, insomnia and palpitations due to the presence of caffeine.

Stomach ulcers have been reported.

Exceptionally, an abnormally low level of certain elements of the blood (platelets) appears, which can be manifested by bleeding from the nose or gums. This requires checking the blood work.

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Actron Interactions

The following interactions are linked to the presence of aspirin, caffeine and paracetamol.

Contraindicated associations

Related to the presence of aspirin:

Oral anticoagulants

Acetylsalicylic acid, at analgesic or antipyretic doses (≥ 500 mg per dose and / or <3 g / day) and in the event of a history of gastro-duoenal ulcer: increased risk of bleeding, especially in the event of gastrointestinal ulcer. duodenal.

Methotrexate used at doses greater than 20 mg / week

Increase in toxicity, especially haematological, of methotrexate (decrease in its renal clearance of methotrexate by acetylsalicylic acid).

Not recommended associations

Related to the presence of aspirin:

Anagrelide

Increase in hemorrhagic events.

Oral anticoagulants, in the absence of a history of peptic ulcer:

Acetylsalicylic acid at analgesic or antipyretic doses (≥ 500 mg per dose and / or <3 g / day): increased risk of bleeding.
Low-dose salicylates: need to be monitored, if necessary, in particular the bleeding time.

NSAIDs

(Including salicylates from 3 g / day in adults)

Increase in the ulcerogenic and digestive hemorrhagic risk.

Clopidogrel

Increase in hemorrhagic risk by addition of antiplatelet activities.

Defibrotide

Increased risk of bleeding.

Low molecular weight and related heparins and unfractionated heparins (curative doses and / or elderly patients)

Acetylsalicylic acid at analgesic or antipyretic doses (≥ 500 mg per dose and / or <3 g / day): Increased risk of hemorrhage (inhibition of platelet function and aggression of the gastroduodenal mucosa by acetylsalicylic acid).
Use another analgesic or antipyretic.

Pemetrexed, in patients with poor to moderate renal function (creatinine clearance between 45 ml / min and 80 ml / min)

Risk of increased toxicity of pemetrexed (decrease in its renal clearance by acetylsalicylic acid at anti-inflammatory doses).

Ticagrelor

Increase in hemorrhagic risk by addition of antiplatelet activities.

Ticlopidine

Increase in hemorrhagic risk by addition of antiplatelet activities. If the association cannot be avoided, close clinical monitoring.

Uricosurics

Decrease in the uricosuric effect by (competition for the elimination of uric acid in the renal tubules).
Use another pain reliever.

Related to the presence of caffeine:

Enoxacin

Increase in plasma caffeine concentrations which may lead to excitations and hallucinations, due to a decrease in its hepatic metabolism.

Combinations subject to precautions for use

Related to the presence of aspirin:

Angiotensin II receptor antagonists

For analgesic or antipyretic doses of aspirin (doses ≥ 500 mg per dose and / or <3 g per day):

Acute renal failure in dehydrated patients, by decrease in glomerular filtration secondary to a decrease in the synthesis of renal prostaglandins. Moreover, reduction of the antihypertensive effect.
Hydrate the patient and monitor renal function at the start of treatment.

Antidiabetics: insulins, chlorpropamide

Enhancement of the hypoglycaemic effect by high doses of acetylsalicylic acid (hypoglycaemic action of acetylsalicylic acid and displacement of the sulfonylurea from its binding to plasma proteins).
Warn the patient and reinforce blood glucose self-monitoring.

Corticosteroids (gluco-) (systemic route)

Decrease in salicylemia during treatment with corticosteroids and risk of salicylate overdose after stopping them (increased elimination of salicylates by corticosteroids).
Adjustment of the doses of salicylates during the combination and after stopping treatment with glucocorticoids.

Diuretics, ACE inhibitors

For acetylsalicylic acid at anti-inflammatory and analgesic or antipyretic doses: acute renal failure in dehydrated patients by reduction in glomerular filtration secondary to a reduction in the synthesis of renal prostaglandins. Moreover, reduction of the antihypertensive effect.
Hydrate the patient and; Look at the kidney function at the start of the treatment.

Interferon alfa

Risk of inhibition of the action of interferon.
Preferably use a non-salicylated antipyretic analgesic.

Methotrexate used at doses less than or equal to 15 mg / week

Increase in toxicity, in particular haematological methotrexate (decrease in its renal clearance by acetylsalicylic acid.
Weekly control of the blood count during the first weeks of the association.
Increased monitoring in the event of deterioration (even slight) of renal function, as well as in the elderly.

Pemetrexed, in patients with normal renal function

Risk of increased toxicity of pemetrexed (decrease in its renal clearance by acetylsalicylic acid at anti-inflammatory doses).
Biological monitoring of the renal function.

Pentoxifylline

Increased risk of bleeding.
Strengthen clinical monitoring and more frequent monitoring of bleeding time.

Linked to the presence of paracetamol:

Antivitamin K

Risk of an increase in the effect of the antivitamin K and the risk of bleeding if paracetamol is taken at maximum doses (4 g / d) for at least 4 days.
More frequent control of the INR. Possible adjustment of the dose of the antivitamin K during treatment with paracetamol and after its discontinuation.

Related to the presence of caffeine:

Dipyridamole

With injectable dipyridamole: reduction of the vasodilator effect of dipyridamole by caffeine.
Interrupt caffeine therapy at least 5 days prior to myocardial imaging with dipyridamole and avoid the consumption of coffee, tea, chocolate or cola within 24 hours of the test.

Stiripentol

Possible increase in plasma concentrations of caffeine, with risk of overdose, by inhibition of its hepatic metabolism.
Clinical monitoring and possible adjustment of the caffeine dosage.

Associations to take into account

Related to the presence of aspirin:

Deferasirox

Increased risk of gastrointestinal ulcer and heporrhagic disease.

Intrauterine device

(Controversial) risk of decreased efficacy of the intrauterine device.

Glucocorticoids (except hydrocortisone)

Increased risk of hemorrhage.

Low molecular weight and related heparins and unfractionated heparins (preventive doses)

The combined use of drugs that act at various levels of hemostasis increases the risk of bleeding. Thus, in subjects under 65 years of age, the combination of heparin at preventive doses, or related substances, with acetylsalicylic acid, whatever the dose, must be taken into account while maintaining clinical monitoring and possibly biological.

Selective serotonin reuptake inhibitors

Increased risk of hemorrhage.

Thrombolytics

Increased risk of bleeding,

Gastrointestinal topicals: salts, oxides and hydroxides of magnesium, aluminum and calcium

Increased renal excretion of salicylates by alkalinization of urine.

Linked to the presence of caffeine:

Ciprofloxacin, norfloxacin

Increase in plasma concentrations of caffeine, by decrease in its hepatic metabolism.

Lithium

In the event of sudden cessation of consumption of coffee or drugs containing caffeine, risk of increased blood lithium.

Mexiletine

Increase in plasma caffeine concentrations, by inhibition of its hepatic metabolism by mexiletine.

Other interactions linked to the presence of paracetamol:

Drugs leading to delayed gastric emptying may lead to slower absorption of paracetamol and thus to a delayed onset of action.
Medicines leading to accelerated gastric emptying (eg metoclopramide), can lead to faster absorption of paracetamol and therefore to a faster onset of action.
The concomitant use of drugs which induce an induction of hepatic enzymes, for example certain hypnotics and antiepileptic drugs (phenobarbital, phenytoin, carbamazepine etc.) or rifampicin can lead to liver damage, even at doses of paracetamol which would otherwise be without risk. In case of excessive alcohol consumption, taking paracetamol, even in therapeutic doses, can lead to liver damage.
The effects of the following drugs are intensified: Combination with chloramphenicol may prolong its half-life and thus potentially increase its toxicity.
Tropisetron and granisetron, which are 5HT-3 serotonin antagonists, can completely inhibit the analgesic effect of paracetamol due to pharmacodynamic interaction.
Concomitant use of paracetamol and AZT (zidovudine) increases the tendency towards a reduction in the number of white blood cells (neutropenia). Also paracetamol should not be taken in combination with AZT, except on medical advice.
It is best to avoid continuous treatment combined with more than one pain reliever; there is little evidence of additional benefit to the patient, and the incidence of side effects is generally additive.

Effects on ability to Drive , use machines &ATHLETES

The attention of athletes is drawn to the fact that this medication contains an active principle which can induce a positive reaction to tests carried out during doping controls.

Warnings and Precautions

Special warnings

If the pain persists for more than 5 days, the fever for more than 3 days or if they worsen, do not continue the treatment without the advice of your doctor or pharmacist.

In case of overdose or mistakenly taking too high a dose, contact a doctor immediately.

Reye’s Syndromes (a rare but very serious disease mainly combining neurological disorders and liver damage) have been observed in children with viral illnesses and receiving aspirin.

Consequently :

in the event of a viral disease, such as chickenpox or an episode of influenza-like illness: do not administer aspirin to a child without the advice of a doctor,
If a child develops consciousness or behavior and vomits in taking aspirin, contact a doctor immediately.

Precautions for use

Before taking aspirin, it is necessary to CONSULT YOUR DOCTOR in the event of:

of gout.
digestive history: haemorrhage, old ulcer of the stomach or duodenum,
kidney or liver disease,
asthma: the occurrence of an asthma attack in some subjects may be linked to allergy to aspirin or NSAIDs; in this case this drug is contraindicated.
important periods or contraception by IUD.

Aspirin increases the risk of bleeding from very low doses, even when the intake is several days old. TELL YOUR ATTENDING DOCTOR, SURGEON, ANESTHESIST OR YOUR DENTIST, in the event that a surgical procedure, even minor, is considered.

This medicine contains sodium. This medicine contains 440 mg of sodium per tablet. To be taken into account in patients controlling their dietary sodium intake.

This medicine can cause insomnia, it should not be taken at the end of the day.

IF IN DOUBT, DO NOT HESITATE TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

During the FIRST 5 MONTHS of your pregnancy, your doctor may, if necessary, prescribe this medication to you on an ad hoc basis.
FROM 6 ^th MONTH OF PREGNANCY, you should IN NO EVENT take OF YOURSELF this drug because its effect on your child can have serious consequences, particularly vascular and renal level, even with only once and even when the child is at term.

Feeding with milk

This medicine passes into breast milk. It is therefore not recommended during breastfeeding regardless of the dose of aspirin to take.
Ask your doctor or pharmacist for advice before taking any medicine.

What happens if I overdose from Actron ?

Intoxication linked to aspirin and paracetamol is to be feared in the elderly and especially in young children (therapeutic overdose or frequent accidental poisoning), in whom it can be fatal.

Symptoms of an aspirin overdose:

Moderate intoxication: tinnitus, decreased sensation of hearing, headache, dizziness are the mark of an overdose and can be controlled by reducing the dosage.
Severe poisoning: Fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular collapse, respiratory failure, high blood sugar;
Symptoms of paracetamol overdose: nausea, vomiting, anorexia, pallor, abdominal pain usually appear within the first 24 hours.
Overdose, from 10 g of paracetamol in adults and 150 mg / kg body weight in a single dose in children, causes hepatic cytolysis likely to lead to a complete and irreversible necrosis, resulting in hepatocellular failure, metabolic acidosis, encephalopathy up to coma and death.
Simultaneously, an increase in hepatic transaminases were observed in lactico dehydrogenase, bilirubin and decreased prothrombin levels that may appear 12 to 48 hours after ingestion.

Emergency driving:

Immediate transfer to a specialized hospital environment;
Rapid evacuation of the product ingested by gastric lavage;
Before starting treatment:
- take a tube of blood to do the plasma dosage of paracetamol,
- control of the acid-base balance;
Treatment of an aspirin overdose typically includes forced alkaline diuresis; hemodialysis or peritoneal dialysis is possible if necessary.
Treatment of paracetamol overdose conventionally comprises the administration as early as possible of the antidote N-acetylcysteine intravenously or orally if possible before the tenth hour.
Symptomatic treatment.

What should I do if I miss a dose?

Not applicable.
Not applicable.
Not applicable.
Not applicable.

What happens if you stop taking Actron ?

Not applicable.
Not applicable.
Not applicable.
Not applicable.

What is Forms and Composition ?

Appearance and shape

Effervescent tablet
Effervescent tablets, packaged in 2, in heat-sealed film (paper / PE / aluminum / Surlyn). Box of 20 tablets.

Other shapes

ACTRON, effervescent tablet, box of 15 heat-sealed films of 2

Composition

Active ingredient Effervescent tablet

Acetylsalicylic acid 0.267 g *
Paracetamol 0.133 g *
anhydrous caffeine 0.04 g *
* per unit dose

actron ingredients

Acetylsalicylic acid .
Paracetamol .
anhydrous caffeine

Excipients with known effects ? : Presence of: Sodium

Other excipients:

Citric acid anhydrous.
Sodium bicarbonate,

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.
The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.