Diprosept Cream Uses, Dosage, Side Effects, Precautions & Warnings

DIPROSEPT, cream, 15 g tube
78 / 100

Generic drug of the Therapeutic class: Dermatology
Active ingredients: Betamethasone , Clioquinol

Drug withdrawn from the market on 06/22/2005

what is Diprosept Cream medication used for and indication?

Preferred indications where local corticosteroid therapy is considered the best treatment:

  •  contact eczema,
  • atopic dermatitis,
  • lichenification.

 Indications where local corticosteroid therapy is one of the usual treatments :

  • stasis dermatitis,
  • psoriasis (excluding very extensive plaques),
  • lichen,
  • genital sclero-atrophic lichen,
  •  non-parasitic prurigo,
  •  dyshidrosis ,
  • annular granuloma,
  • discoid lupus erythematosus,
  • seborrheic dermatitis except for the face,
  • symptomatic treatment of pruritus from mycosis fungoides.

Indications of circumstance for a short duration :

  • insect bites and parasitic prurigo after etiological treatment.
  • The cream form is more particularly intended for acute, oozing lesions.

Diprosept Cream Dosage

  • Treatment should be limited to 1 or 2 applications per day. An increase in the number of daily applications may worsen the side effects without improving the therapeutic effects.
  • The treatment of large surfaces requires monitoring the number of tubes used.
  • It is advisable to apply the product in spaced strokes, then to spread it by massaging lightly until it is fully absorbed.
  • Certain dermatoses (psoriasis, atopic dermatitis, etc.) make gradual cessation desirable. It can be obtained by reducing the frequency of applications and / or by using a less strong or less dosed corticosteroid.

Diprosept Cream Contraindications

  • Hypersensitivity to any of the products contained in the preparation.
  • Primary bacterial, viral, fungal or parasitic infections.
  • Ulcerated lesions.
  • Acne.
  • Rosacea.
  • Application to the eyelids (risk of glaucoma).
  • Do not apply to the breasts during breastfeeding because of the risk of ingestion of the product by the newborn.

how does Diprosept Cream work?

  • The extent of transdermal passage and systemic effects depend on the size of the surface treated, the degree of epidermal damage, and the duration of treatment.
  • These effects are all the more to be feared as the treatment is prolonged.

Diprosept Cream Side Effects

Adverse effects due to corticosteroid :

  • The prolonged use of corticosteroids of strong activity can cause atrophy of the skin, telangiectasias (to be feared particularly on the face), stretch marks (at the root of the limbs in particular, and occurring more readily in adolescents), secondary ecchymotic purpura with atrophy, skin fragility.
  • In the face, corticosteroids can create perioral dermatitis or worsen rosacea (see warnings and contraindications).
  • A delayed healing of sluggish wounds, bedsores, leg ulcers can be observed (see contraindications).
  • Possible systemic effects (see warnings: cushingoid syndrome, growth retardation, acute adrenal insufficiency).
  • Acneiform or pustular eruptions, hypertrichosis, depigmentation have been reported.
  • Secondary infections, particularly under occlusive dressing or in folds and allergic contact dermatoses have also been reported with the use of topical corticosteroids.

Adverse effects due to the antiseptic :

  • Risk of hypersensitivity.
  • Yellow discoloration of the skin, disappearing quickly.

Diprosept Cream Interactions

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Effects on ability to Drive and use machines

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Warnings and Precautions


  • Prolonged use on the face of moderately active corticosteroids exposes the occurrence of corticosteroid-induced and paradoxically corticosensitive dermatitis, with rebound after each stop. A gradual weaning, particularly difficult, is then necessary.
  • Due to the passage of the corticosteroid into the systemic circulation, treatment over large areas or under occlusion may cause the systemic effects of systemic corticosteroid therapy, particularly in infants and toddlers.
  • They consist of a cushingoid syndrome and a slowing of growth. These accidents disappear when treatment is stopped, but abrupt cessation can be followed by acute adrenal insufficiency.


  • In infants, it is preferable to avoid corticosteroids of strong activity. It is necessary to be particularly wary of the phenomena of spontaneous occlusions which can occur in the folds and under the layers.
  • In the event of a bacterial or mycotic infection of a corticosensitive dermatosis, precede the use of the corticosteroid with a specific treatment.
  • If an intolerance appears, the treatment must be interrupted and the cause must be sought.



  • Animal teratogenesis studies have not been performed with topical corticosteroids. However, studies of oral corticosteroids in pregnant women have not shown a higher risk of malformation than that observed in the general population.
  • Accordingly, these drugs can be prescribed during pregnancy if needed.


  • Breast-feeding is possible while taking this medicine.
  • Do not apply to the breasts during breastfeeding because of the risk of ingestion of the product by the newborn.

What happens if I overdose from Diprosept Cream ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking Diprosept Cream ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.


Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
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