Hexaquine Tablets Uses, Dosage, Side Effects, Precautions

Hexaquine Tablets Uses, Dosage, Side Effects, Precautions

Hexaquine Tablets drug >> Generic drug of the Therapeutic class: Rheumatology
active ingredients: Quinine benzoate , Thiamine

Important to know about Hexaquine Tablets ?

  • This medicine is indicated for the treatment of nocturnal muscle cramps in adults.
  • Before prescribing Hexaquine Tablets, your doctor should evaluate the benefit to you of this treatment from the risk of developing side effects.

Hexaquine Tablets uses and  indication

Hexaquine Tablets Dosage



  • 1 to 3 tablets at bedtime, 174.4 mg to 261.6 mg quinine base daily.
  • Do not exceed 3 tablets maximum per day.
  • Patients should be monitored during the first few weeks of treatment because of side effects . A benefit should be observed in the days following the start of treatment. In the absence of benefit after 4 weeks, treatment with quinine should be permanently discontinued.
  • Treatment with quinine is not a long-term treatment for idiopathic night cramps.

Administration mode:

Oral way.

Severe renal insufficiency

  • Dosage should be reduced in cases of severe renal impairment.


This medication is contraindicated in the following cases:

– history of hypersensitivity to quinine, or to one of the constituents (thiamine),

Myasthenia gravis

Intraventricular conduction disturbances,

Concomitant treatment with quinine or derivatives,

In combination with astemizole (see section Interactions with other medicinal products and other forms of interactions ).

· Contraindication linked to the route of administration: history of proctitis or rectal bleeding.

How it works Hexaquine Tablets?


Hexaquine Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Adverse effects not dependent on the dose ingested: allergic reactions sometimes serious, which can be manifested by:

  • · Skin reactions: redness, purpura, photosensitization,
  • · Decreased blood levels of platelets or all blood components,
  • · Some cases of liver damage (hepatitis) have been reported.
  • Adverse dose-dependent effects: ringing, hearing loss, dizziness, vision problems, headache.
  • If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Hexaquine Interactions

The data available to date do not suggest the existence of clinically significant interactions.

Warnings and Precautions

Special warnings:

  • The occurrence of immuno-allergic accidents such as thrombocytopenia, hepatitis, allergy, requires the immediate and definitive cessation of this treatment and the subsequent eviction of quinine, including drinks containing it.
  • Quinine can lead to unpredictable and potentially life-threatening immunoallergic attacks. Quinine should not be used in patients who have had a history of side effects when administered as a drug or in drinks containing it.

Precautions for use:

  • Before using quinine for the treatment of idiopathic night cramps, all risks,  should be carefully considered in relation to the expected potential benefit. These risks are particularly present in the elderly.
  • Treatment with quinine should be considered only in the case of very painful and frequent cramps, when other causes of cramps have been ruled out and non-pharmacological measures have failed. Quinine should not be used for this indication during pregnancy.
  • The administration of quinine can lead to the appearance of cinchonism, generally more serious in case of overdose, but which can also appear for therapeutic doses usually used.
  • Patients should be warned not to exceed the prescribed doses because of the possibility of serious and irreversible side effects during overdose.
  • Any treatment of nocturnal idiopathic cramps with quinine should be discontinued if symptoms of cinchonism occur. These symptoms include dizziness, tinnitus, headache, nausea and blurred vision
  • This medicine contains azo coloring agents (orange-yellow (E110) and cochineal red A (E124)) and may cause allergic reactions.
  • This medicine contains sucrose. It is not recommended for use in patients with fructose intolerance, glucose-galactose malabsorption or sucrase / isomaltase deficiency.

Drive and use machines

Not applicable.



  • During pregnancy, quinine should be reserved for the sole treatment of malaria.This medication should not be prescribed in pregnant women for the indication of idiopathic cramps.
  • A few cases of eye abnormalities and hearing impairment have been reported with high doses of quinine during pregnancy. At therapeutic doses, no incidents were reported.


  • It is advisable to avoid this medication during breastfeeding.

What happens if I overdose from Hexaquine Tablets ?

The most common signs of overdose are:

  • Tinnitus, hearing loss and dizziness. Permanent deafness is sometimes observed after administration of toxic doses.
  • Amblyopia, tunnel vision, double vision and night blindness. Recovery is slow but generally complete. Spasms of the central retinal artery have been described.
  • Effect quinidine-like resulting in hypotension, conduction disorders, angina symptoms and ventricular tachycardia.
  • Local irritation to the gastrointestinal tract causing nausea, vomiting, abdominal pain and diarrhea.

Oral administration of more than 3 g, in a single dose, can cause serious or even fatal intoxication in adults, preceded by central depression and seizures. Smaller doses can be fatal in children.

Arrhythmia, hypotension and cardiac arrest may result from the cardiotoxic effect of quinine, while ocular toxicity may result in blindness.

What to do : gastric evacuation and stomach lavage. Administration of activated charcoal.

Symptomatic treatment of abnormalities in a hospital environment.

What is  Forms and Composition?

  • Coated tablet (dark orange):   Box of 18, blister packs of 9.
  p cp
Quinine benzoate 120 mg
(in anhydrous quinine: 87.2 mg / cp)
Thiamine (DCI) hydrochloride 32 mg
  • Excipients: purified natural essential oil of selected Melaleuca viridiflora , sucrose, corn starch, povidone, anhydrous colloidal silica (Aerosil 200), potato starch, hydrated colloidal silica (Sipernat 50), talc, stearic acid, purified water. Coating: gum arabic, hydrated colloidal silica (Levilite), shellac, rosin, gelatin, sucrose, talc, carnauba wax, yellow-orange S (E110), red cochineal A (E124), indigotin (E132).
  • Excipients with known effect: yellow orange (E110), red cochineal A (E124), sucrose.


Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
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