Diprolene ointment Uses, Dosage, Side Effects, Precautions & Warnings

what is diprolene used to treat

Generic drug of the Therapeutic class: Dermatology
active ingredients: Betamethasone

what is diprolene cream used for and indication?

  • Corticosteroid-sensitive lesions, limited in surface, having resisted a corticosteroid of the lower category.
  • Limited and resistant plaques of psoriasis particularly in their palmoplantar locations, lichenification (neurodermatitis), discoid lupus erythematosus, lichens.
  • Hypertrophic scars.

Note: after a treatment of attack generally brief, the relay is possibly ensured by a corticosteroid of a lower class.

Diprolene Dosage

  • Applications are limited to 2 per day. An increase in the number of daily applications may worsen the side effects without improving the therapeutic effects.
  • The treatment of large surfaces requires monitoring the number of tubes used.
  • Spread the product on the lesions and allow it to penetrate with a light massage.
  • Stopping treatment will be gradual by reducing the frequency of applications and / or by using a less strong or less dosed corticosteroid.

Diprolene Contraindications


  • Hypersensitivity to one of the constituents.
  • Bacterial, viral, primary fungal and parasitic infections even if they have an inflammatory component.
  • Ulcerated lesions.
  • Acne and rosacea.
  • Infant (see warnings).


  • Pregnancy: the safety of this medication during pregnancy has not been established: use is therefore not recommended during the first three months of pregnancy.

how does Diprolene work?

Pharmacotherapeutic group: corticosteroids with strong activity, ATC code: D07AC01.

  • The presence of propylene glycol in the formulation of this proprietary product increases the vasoconstrictor effect of betamethasone dipropionate, leading to systemic penetration of the active principle; the activity of betamethasone dipropionate is enhanced.
  • The specialty DIPROLENE is a topical corticosteroid of very strong activity (class I).

How To Store Diprolene ?

Shelf life before opening:

  • 3 years.
  • Store at a temperature not exceeding 30 ° C.
  • After opening: 3 months.

Diprolene Side Effects

  • Are to be feared in the event of prolonged use: cutaneous atrophy, telangiectasias (to be feared particularly on the face), stretch marks (at the root of the limbs in particular and occurring more readily in adolescents); ecchymotic purpura secondary to atrophy, skin fragility.
  • In the face, corticosteroids can create a perioral dermatosis or else create or worsen rosacea (see warnings and contraindications).
  • A delay in healing of sluggish wounds, bedsores, leg ulcers can be observed (see contraindications).
  • Possibility of systemic effects (see warnings: cushingoid syndrome, growth retardation; acute adrenal insufficiency).
  • The following have been reported: acneiform or pustular rashes, hypertrichosis, depigmentation.

Diprolene Interactions

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Effects on ability to Drive and use machines

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Warnings and Precautions

Special warnings

Prolonged use on the face of class I, II and III corticosteroids exposes the occurrence of corticosteroid-induced and paradoxically corticosteroid-sensitive dermatitis, with rebound after each stop. A gradual weaning, particularly difficult, is then necessary.

  • Due to the force of action of this steroid, when used on large surfaces or under occlusion, an important absorption of the product with a passage in the flow can occur causing systemic effects of corticosteroids through oral or parenteral (particularly in infants and young children: see contraindications), and in particular a temporary slowing down of adrenal function (cushingoid syndrome and slowing down of growth); these accidents disappear when treatment is stopped, but abrupt stopping may be followed by acute adrenal insufficiency.
  • In children, treatment may not be exceptional and under strict supervision.

Precautions for use

  • One should be particularly wary of spontaneous occlusion phenomena which may occur in folds or under waterproof pants.
  • In case of bacterial or fungal dermatitis steroid-a, should be to precede the use of corticosteroid specific treatment, or possibly, and only in certain cases, to use a corticosteroid combination and specific treatment .
  • If a local intolerance appear, treatment should be interrupted and the cause must be sought.
  • In case of palpebral application, the duration of treatment should be limited. A prolonged application exposes in fact to risks of ptosis by muscular damage of the levator of the eyelid, glaucoma, rebound effect.

Visual disturbances may appear during systemic or local corticosteroid therapy (especially nasal, inhaled and intraocular). In the event of blurred vision or the appearance of any other visual symptom appearing during corticosteroid therapy, an ophthalmological examination is required to look for visual disturbances, in particular cataracts, glaucoma, or more lesion. rare such as central serous chorioretinopathy, described with the administration of corticosteroids by systemic or local route.

This medicine contains propylene glycol and may cause skin irritation.



  • The safety of this drug during pregnancy has not been established; use is therefore not recommended during the first three months of pregnancy.

What happens if I overdose from Diprolene ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking Diprolene ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?


  • 0.05% ointment:   Tube of 15 g.


  p 100 g
Betamethasone 0.05 g
(either micronized betamethasone dipropionate: 0.064 g)
  • Excipients: propylene glycol, white wax, propylene glycol stearate, white petrolatum.


Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

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