CALPEROS D3 500 mg / 400 IU Uses, Dosage, Side Effects & Precautions

CALPEROS D3, lozenge, box of 1 bottle of 60
82 / 100

Generic drug of the Therapeutic class: Metabolism and nutrition
Active ingredients: Cholecalciferol , Calcium

what is CALPEROS D3 medication used for and indication?

This medication is indicated for adults in the following situations:

  • in the elderly, in case of calcium and vitamin D deficiency,
  • in combination with treatment for osteoporosis when calcium and vitamin D intake is insufficient.


5 presentations are available for this drug:

  • 1 polyethylene bottle (s) of 10 tablet (s)
  • 1 polyethylene bottle (s) of 20 tablet (s)
  • 1 polyethylene bottle (s) of 30 tablet (s)
  • 1 polyethylene bottle (s) of 60 tablet (s)
  • 1 polyethylene bottle (s) of 180 tablet (s)
Pharmaceutical class mineral supplements
Active substance (s) for one tablet: calcium carbonate (1250 mg), cholecalciferol concentrate, powder form
General medicine no
Pharmaceutical form tablet to suck
Route (s) of administration oral
Social security reimbursement rate 65%
Conditions of issue restricted prescription drug


1 tablet morning and evening, or 2 tablets per day.

CALPEROS D3 Contraindications

Never take CALPEROS D3, tablet to suck in the following cases:

  • allergy to vitamin D or to one of the constituents,
  • abnormally high amount of calcium in the blood (hypercalcaemia),
  • exaggerated elimination of calcium through the urine (hypercalciuria),
  • kidney stones (calcium lithiasis),
  • prolonged immobilization accompanied by hypercalciuria and / or hypercalcemia,
  • phenylketonuria (hereditary disease detected at birth), due to the presence of aspartame.


How To Take CALPEROS D3 ?

Administration mode

  • Oral route.
  • Tablet to suck then take a glass of water.

Duration of the treatment

  • In all cases, strictly follow your doctor’s prescription.

how does CALPEROS D3 work?

Pharmacotherapeutic group: Vitamin D calcium intake, ATC code: A12AX (A: digestive system and metabolism – Drug active on the calcium balance) .

Action mechanism

  • Vitamin D corrects insufficient intake of vitamin D.
  • It increases the intestinal absorption of calcium and its fixation on the osteoid tissue.
  • Calcium intake corrects dietary calcium deficiency.

The daily calcium requirements are of the order of 1000 to 1500 mg of elemental calcium and 500-1000 IU / day of vitamin D

  • Vitamin D and calcium correct secondary senile hyperparathyroidism.
  • An 18-month, double-blind, placebo-controlled study, involving 3270 women aged 84 ± 6 years living in healthcare facilities, showed a significant decrease in plasma PTH levels. At 18 months, the results of the intention-to-treat analysis revealed 80 hip fractures in the calcium-vitamin D group and 110 hip fractures in the placebo group (p = 0.004). Under the conditions of this study, the treatment of 1387 women prevented 30 hip fractures. After an extension up to 36 months, the following results were obtained: 137 hip fractures in the calcium-vitamin D group and 178 in the placebo group (p ≤ 0.02).

How To Store CALPEROS D3 ?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date stated on the box. The expiration date refers to the last day of that month .
  • Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

CALPEROS D3 Side Effects

Like all medicines, CALPEROS D3, lozenge can cause side effects, although not everybody gets them.

  • Constipation, diarrhea,
  • Epigastric pain, bloating,
  • Nausea,
  • Increase in the amount of calcium in the blood or urine in some cases.
  • Itching, rash, and hives.

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

CALPEROS D3 Interactions

Combinations subject to precautions for use


  • Decreased digestive absorption of cyclins.
  • Take calcium salts away from cyclins (more than 2 hours, if possible).


  • Risk of serious arrhythmias.
  • Clinical monitoring and, if necessary, control of ECG and serum calcium.


  • Decreased digestive absorption of bisphosphonates.
  • Take calcium salts away from bisphosphonates (at least 30 minutes to more than 2 hours, if possible, depending on the bisphosphonate).


  • Decreased digestive absorption of estramustine.
  • Take calcium salts away from estramustine (more than 2 hours, if possible).

Iron (salts) (oral)

  • Decreased digestive absorption of iron salts.
  • Take iron salts between meals and in the absence of calcium.


  • Decreased digestive absorption of zinc by calcium.
  • Take the calcium salts away from the zinc (more than 2 hours if possible).


  • Decreased digestive absorption of strontium.
  • Take strontium away from calcium salts (more than 2 hours if possible).

Thyroid hormones

Decreased absorption of thyroid hormones

  • Take calcium salts away from thyroid hormones (more than 2 hours if possible).

Enzyme-inducing anticonvulsants

  • Decrease in vitamin D concentrations more marked than in the absence of an inducer.
  • Determination of vitamin D concentrations and supplementation if necessary.


  • Decrease in vitamin D concentrations more marked than without treatment with rifampicin.
  • Determination of vitamin D concentrations and supplementation if necessary.

Associations to take into account

Thiazide and related diuretics

  • Risk of hypercalcemia by decreased urinary elimination of calcium.


  • Decreased absorption of vitamin D.

Effects on ability to Drive and use machines

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Warnings and Precautions

Precautions for use

Use this medication WITH CAUTION if:

  • of prolonged treatment: it is necessary to have the amount of calcium in the blood and excreted in the urine (calciuria) checked regularly. Depending on the result, your doctor may have to reduce or even interrupt your treatment.
  • additional administration of calcium and vitamin D in high doses which must be done under strict medical supervision,
  • associated treatment with bisphosphonates as well as in the event of treatment with an antibiotic from the cyclin family: it is advisable to wait at least two hours between taking these medicines and CALPEROS D3.
  • sarcoidosis or kidney failure.




  • This product can be used during pregnancy and lactation. However, the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.
  • During pregnancy, cholecalciferol overdose should be avoided:
    • Overdoses of vitamin D during pregnancy have teratogenic effects in animals.
    • In pregnant women, overdoses in vitamin D should be avoided as permanent hypercalcaemia can result in children physical and mental retardation, aortic stenosis or retinopathy supravalvar. However, several children were born without malformation after administration of very high doses of vitamin D3 for hypoparathyroidism in the mother.

Feeding with milk

  • Vitamin D and its metabolites pass into breast milk.

What happens if I overdose from CALPEROS D3 ?

  • When taking an excessive dose of this medicine, the following symptoms may appear: nausea, vomiting, intense thirst, constipation.
  • If such effects occur, tell your doctor immediately who will take the necessary measures.
  • In case of prolonged overdose, calcifications may appear in the vessels or tissues.

What should I do if I miss a dose?

  • Do not take a double dose to make up for the tablet you forgot to take.

What happens if you stop taking CALPEROS D3 ?

If you stop taking CALPEROS D3, tablet to suck

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

Appearance and shape

  • Lack of information in the MA.
  • 60 tablets in a bottle (Polyethylene).


Active ingredient Tablet to suck

Active ingredients: Cholecalciferol , Calcium

Excipients with known effects ?

  • Aspartame

Other excipients:

  • Povidone.
  • Talc.
  • Magnesium stearate.
  • Xylitol.

Mint aroma in powder form:

  • Peppermint essential oil.
  • Gum arabic


Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

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