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Celecoxib

The text below is about the active substance Celecoxib.

what is celecoxib?

  • Celecoxib relieves pain, inhibits inflammation, and lowers fever.
  • For joint pain , rheumatoid arthritis and Bechterew’s disease. Sometimes also used for other types of pain, such as osteoarthritis (worn joints) or menstrual pain.
  • The pain diminishes 1 to 2 hours after ingestion . The effect lasts for 12 to 24 hours. With inflammation, redness and swelling will diminish within one to two weeks.
  • Note: risk of stomach and intestinal ulcers and bleeding. Are you over 60, have you previously had a stomach or intestinal ulcer, or are you taking anti-clotting medications? Then you need a stomach protector . Ask your doctor or pharmacist about this
  • Watch out with alcohol. Alcohol increases the risk of stomach upset.
  • Many interactions with other drugs. Ask your pharmacist if it is safe to take celecoxib with your other medicines, including those bought without a prescription.
  • Are you pregnant or planning to become pregnant? Ask your doctor if you can take this medicine. This drug can be bad for the baby. DO NOT use if you are in pain in the last 3 months of your pregnancy.

What class of medication is celecoxib?

This medication is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation).

What does celecoxib do and what is celecoxib used for?

Celecoxib is an anti-inflammatory pain reliever . These types of painkillers are also called NSAIDs . Celecoxib belongs to a special group of NSAID painkillers called coxibs.

It has an analgesic, anti-inflammatory and fever-reducing effect.

Doctors prescribe it for pain that also involves inflammation, such as joint pain , rheumatoid arthritis and Bechterew’s disease . It is also sometimes used for other types of pain , such as osteoarthritis or menstrual pain .

Joint pain

  • Symptoms
  • On and around the joints are muscles, tendons, tendons sheaths, joint membranes and bursa. These can become damaged and inflamed, causing pain, swelling and redness around a joint. Examples of this are bursitis, tennis elbow, carpal tunnel syndrome in the wrist and RSI complaints.
  • The complaints usually arise because you overload the joint or because the joint is turned in an unnatural direction. Like a sprain. The complaints also arise from bruises.

Treatment

  • Avoid movements that hurt. Sometimes it is necessary to temporarily elevate the body part. In case of a bruise or spraining, immediately cool the joint with ice. You can also protect the joint with a pressure bandage so that you do not make unnatural movement again.
  • If you have a lot of pain, paracetamol is the safest medicine. If paracetamol is insufficient, doctors usually prescribe anti-inflammatory painkillers, such as diclofenac, ibuprofen or naproxen. These cause stomach upset in some people.
  • Celecoxib, like the other painkillers of the ‘coxib-type’, gives slightly less chance of these stomach complaints. Hence, doctors prescribe this medicine to people who have previously developed a stomach or intestinal ulcer or bleeding from painkillers.

Operation

  • This drug inhibits inflammation, reducing redness, swelling and pain.
  • The analgesic effect starts 1 to 2 hours after ingestion and lasts for 12 to 24 hours. The redness and swelling will subside after one to two weeks.

Bekhterev’s disease

Symptoms

  • Bechterew’s disease (ankylosing spondylitis) is an inflammation of the joints of the pelvis and spine. It’s a rheumatic disease.
  • With Bechterew’s disease you suffer from pain and stiffness in the lower back. Especially in the morning after getting up or after sitting for some time. The pain disappears through movement. Fatigue can cause the pain to reappear during the day.

Treatment

  • Bechterew’s disease is treated as soon as possible with drugs that slow the progression of this disease and reduce pain. You will usually first be given an anti-inflammatory pain reliever, such as ibuprofen, diclofenac, or naproxen. These cause stomach upset in some people.
  • Celecoxib, like the other painkillers of the ‘coxib-type’, gives slightly less chance of these stomach complaints. Hence, doctors prescribe this drug to people who have previously developed a stomach or duodenal ulcer or bleeding from painkillers.
  • If this does not stop the disease sufficiently, your doctor can prescribe special medicines, usually sulfasalazine. This drug counteracts the cause of the joint inflammation. The effect of sulfasalazine is not immediately noticeable, but only after a few weeks. In the meantime, the doctor can prescribe celecoxib for the inflammation and pain.

Operation

  • This drug inhibits inflammation, reducing redness, swelling and pain.
  • The analgesic effect starts within 1 to 2 hours after ingestion. This effect lasts for approximately 12 to 24 hours. The redness and swelling will subside after a few days to a week.

Arthrosis

Symptoms

  • Osteoarthritis is a disease of the cartilage in a joint.
  • The cartilage lines the bone ends in the joint. In osteoarthritis, the cartilage is affected, usually in the hip or knee. This causes pain and stiffness. This can make you have trouble moving and have trouble sleeping. The complaints can disappear or come back now and then.

Treatment

  • The complaints can be reduced by moving the painful joint and by training the muscles. But do not overload the joint.
  • Paracetamol is the best choice for pain. This has the fewest side effects and usually works as well as anti-inflammatory painkillers. If paracetamol is not effective after two weeks, the doctor can also prescribe an anti-inflammatory painkiller, such as ibuprofen, diclofenac or naproxen.
  • These cause stomach upset in some people. Celecoxib, like the other painkillers of the ‘coxib-type’, gives slightly less chance of these stomach complaints. Hence, doctors prescribe this drug to people who have previously developed a stomach or duodenal ulcer or bleeding from painkillers.

Effect

  • The analgesic effect starts within 1 to 2 hours after ingestion. This effect lasts for approximately 12 to 24 hours. The pain and stiffness will ease after about a week.

What is the major side effect of celecoxib?

In addition to the desired effect, this can cause drug side effects.

The most common side effects are the following.

Sometimes (affects 10 to 30 in 100 people)

  • Rise in blood pressure . Do you have high blood pressure or use blood pressure reducers? Then this drug can increase blood pressure . Consult with your doctor. The doctor may be able to prescribe another anti-inflammatory pain reliever , such as diclofenac or ibuprofen. If you do need to use celecoxib, your doctor will check your blood pressure more closely.

Rare (affects 1 to 10 in 100 people)

  • Upset stomach: stomach irritation, stomach ache, nausea, vomiting, feeling full, lack of appetite, belching and heartburn. This is less likely if you take this medicine with food and a glass of water or milk. Do not consume alcohol or other foods that irritate the stomach, such as pungent herbs. Do you suffer from esophagitis due to rising stomach acid? The complaints can get worse. If you notice this, contact your doctor. People over the age of 60 are more likely to have side effects from this drug. Doctors therefore sometimes prescribe a stomach protector . Even if you are only going to use this medicine for a few days.
  • Intestinal complaints : diarrhea, constipation and flatulence.
  • A stomach or intestinal ulcer or other serious damage to the stomach, intestines or esophagus. You will notice nagging pain in the upper abdomen, severe stomach pain or pain behind the breastbone. These damage can cause bleeding in the stomach and intestines. You will notice this by bloody diarrhea or black tarry stools . Then stop using and contact a doctor. In case of stomach bleeding, you may vomit blood. Then contact a doctor immediately. Have you ever had a stomach or intestinal ulceror any other serious stomach or intestinal disease, such as stomach or intestinal bleeding? You are then more likely to have side effects on the stomach and intestines. Talk to your doctor about whether this medication is right for you. Your doctor may prescribe a stomach-protecting drug in addition to this medication. Even if you will only be taking this medicine for a few days.
  • Do you have esophageal stenosis, a narrowing of the esophagus? You are more likely to get damage to the esophagus. Discuss this with your doctor. You may be able to switch to a different medication.
  • Headache, vertigo and dizziness. This usually passes once you have become used to this drug.
  • Skin rash with itching. Very rarely this rash is caused by allergy . The rash can very rarely worsen or develop under the influence of bright sunlight or UV light from tanning beds. If you have psoriasis: it may be more likely to affect you. Contact your doctor if your symptoms get worse.
  • Hypersensitivity to this drug. You will notice this by a rash, hives and itching. Then consult your doctor. Very rarely, a severe rash with fever or blisters may develop. Then contact a doctor immediately.
    A serious hypersensitivity can be noticed by breathlessness or a swollen face. Then see a doctor immediately. You should not use this medicine afterwards. Therefore, inform the pharmacist that you are hypersensitive to celecoxib. The pharmacy team can then make sure that you do not receive this medicine or another anti-inflammatory pain reliever again.
  • Thick ankles or wrists due to fluid retention in the arms and legs ( edema ).
  • Shortness of breath due to fluid accumulation in the lungs . Especially people with heart failure can suffer from this. Consult your doctor if your symptoms, such as shortness of breath and fluid retention, increase.

Very rare (affects less than 1 in 100 people)

  • Inflammation in the oral cavity and on the tongue.
  • Ringing in the ears or hearing loss . Contact your doctor if you have these symptoms.
  • Blurred or double vision. This usually passes once you have become used to this drug.
  • Palpitations , chest pain and an accelerated heartbeat . Have you had angina (heart spasm), or have ever had a stroke or heart attack. Then you can only use this medicine for a short time. Namely no longer than two weeks in a row. Discuss this with your doctor. Your doctor may be able to prescribe a different medication.
  • Hair loss .
  • Psychological complaints , such as insomnia, fatigue, drowsiness, nightmares, restlessness, agitation, confusion, memory disorders, nervousness, anxiety, depression and hallucinations .
  • celecoxib side effects kidney. You will notice this in swollen ankles and feet. If this happens, contact your doctor or pharmacist.
  • Blood disorders, inflammation of the pancreas or liver inflammation . Consult your doctor if you have any of the following symptoms: sudden severe pain in the upper abdomen, jaundice, unexplained bruising, extreme tiredness, sore throat with fever and blisters in the mouth. Also talk to your doctor if you have pancreas problems. The complaints can get worse.

Very rare, when used for several weeks

  • Heart disease , such as more likely to have a heart attack or stroke . The risk of cardiovascular disease is higher in people who are already more likely to develop cardiovascular disease. People with high blood pressure , high cholesterol, diabetes, angina pectoris, display legs, narrowing or blockage of the leg artery, people who smoke, and people who have ever had a heart attack or thrombosis : talk to your doctor before taking this medicine . Your doctor may be able to prescribe a different anti-inflammatory pain reliever .

Consult your doctor if you experience too much of any of the above side effects or if you experience any other side effects that worry you.

Explanation of frequencies

  • Regular : affects more than 30 in 100 people
  • Uncommon : affects 10 to 30 in 100 people
  • Rare : affects 1 to 10 in 100 people
  • Very rare : affects less than 1 in 100 people

celecoxib dose

Always check the pharmacy label for the correct dosage .

When?

Taking the capsule with or after a meal will reduce the risk of stomach side effects.

How long?

  • Chronic joint infections , such as rheumatoid arthritis and Bechterew’s disease. It may take 1-2 weeks for the inflammation to subside. For rheumatoid arthritis, doctors usually prescribe this drug when the rheumatism drugs have yet to take effect or during periods when the disease is getting worse.
  • Pain , such as joint pain . Contact your doctor if this pain reliever is still not effective after two weeks. A different pain reliever may be more suitable for you. Have you used this medicine for several weeks and still have a lot of problems with your joints? Then contact your doctor.
  • Short-term joint inflammation . For joint infections such as bursitis and tendonitis, you usually need to take this medicine for a few days before the inflammation has healed. You will notice this by a decrease in redness, pain and swelling .
  • Osteoarthritis . Do not use this medication for more than 2 weeks in a row. If the symptoms worsen, you can use it again. Ask your doctor how long this is possible again and for how long and how often you can use it.
  • Menstrual complaints , such as pain, cramps and excessive blood loss.
    Do you mainly suffer from pain and cramps? Start immediately when your period starts and swallow for 2-3 days. Do you suffer from too much blood loss during menstruation ? Then use this medicine for the first three days of your period . Start at least one day before you expect your period . After 3-6 months, try to see if you still need this medication. Do not use it for once and see if the complaints have already decreased.
  • Other pains , such as surgical pain . Stop use when the pain has disappeared or is sufficiently tolerated.

What if I miss a dose?

In chronic pain it is important to take this medicine consistently. If you do miss a dose :

  • If you are taking this medicine once a day , will it be more than 8 hours before you normally take the next dose ? Then take the forgotten dose . Does it take less than 8 hours? Then skip the forgotten dose .
  • If you are taking this medicine twice a day , will it be more than 4 hours before you normally take the next dose ? Then take the forgotten dose . Does it take less than 4 hours? Then skip the forgotten dose .

Can I drive a car, drink alcohol, and eat or drink anything with this medicine?

driving a car?

Dizziness or dizziness occasionally occurs with this medicine. Do not participate in traffic if this affects you.

celecoxib and drinking alcohol?

Alcohol irritates the stomach. This may make your stomach upset sooner. Try drinking alcohol in moderation at first. You can then assess for yourself whether this will bother you a lot. In general, a glass of wine a few times a week is no problem.

eat everything?

This drug causes stomach upset in some people. Do you suffer from this? Don’t use foods that irritate the stomach, such as pungent herbs.

This drug interacts with other drugs. The text below only lists the active ingredients of these drugs, not the brand names. You can check whether your medicine contains one of these active substances in your package leaflet under the heading ‘composition’.

celecoxib interactions

The drugs with which the main interactions occur are the following.

Other anti-inflammatory painkillers (these are also called NSAIDs or coxibs). Using both painkillers at the same time doubles the risk of side effects, such as gastrointestinal complaints. The names of other anti-inflammatory painkillers are aceclofenac, acetylsalicylic acid, carbasalate calcium, dexketoprofen, diclofenac, etoricoxib, phenylbutazone, flurbiprofen, ibuprofen, indometacin, ketoprofen, meloxicam, suly-indrofen, naprofenicroxamazone, sulyaprofenazone, naproxamazone, napumoxiroxamazone and naproxamazone. So do not use these painkillers at the same time as celecoxib.

The anticoagulants acenocoumarol, phenprocoumon, acetylsalicylic acid and carbasalate calcium. With the combination you are more likely to have side effects on the stomach or even stomach bleeding. Usually the doctor will prescribe a stomach protector to prevent these stomach complaints. Pay extra attention to the effect on your stomach and consult your doctor if you have stomach complaints. Celecoxib can also sometimes enhance the action of the anticoagulant. On your next visit to the Thrombosis Service, tell the Thrombosis Service that you are taking or have taken celecoxib.

The anticoagulants apixaban, dabigatran and rivaroxaban. These drugs increase the risk of bleeding in the stomach and intestines. Pay extra attention to the effect on your stomach and consult your doctor if you have stomach complaints. Usually the doctor advises you to take a stomach protector to prevent stomach upset. Consult with your doctor whether this is necessary for you.

Water tablets (chlorthalidone, chlorothiazide, clopamide, epitizide, hydrochlorothiazide, indapamide, bumetanide, furosemide, amiloride, eplerenone, spironolactone and triamterene). Medicines from the group of ACE inhibitors and Angiotensin II blockers , used for high blood pressure and heart failure , such as enalapril, perindopril, lisinopril and losartan. Celecoxib can reduce the effects of these drugs. Discuss this with your doctor. You can safely use paracetamol .

  • Are you taking any of these high blood pressure medications and are you now taking celecoxib? Your blood pressure may increase if you take celecoxib for more than two weeks. Ask your doctor to check your blood pressure extra.
  • Are you taking any of these heart failure medications and will you now be taking celecoxib? Your heart failure symptoms may get worse. Do you notice that your ankles or feet are getting thicker, or are you more likely to be short of breath? Then contact your doctor.
  • Are you taking any of these medicines after a heart attack or for kidney disease and are you now taking celecoxib? Ask your doctor or pharmacist for advice.

Beta blockers , such as acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, celiprolol, metoprolol, oxprenolol, pindolol and propranolol. The effect of these medicines for high blood pressure or heart failure may be reduced by the use of this pain reliever .

  • Are you using the beta blocker for high blood pressure ? If you are taking the pain reliever for more than two weeks, see your doctor for extra blood pressure monitoring .
  • Are you using the beta blocker for heart failure ? Your symptoms may get worse or come back. Contact your doctor if your feet or ankles swell again, or if you become more short of breath again.
  • Are you using the beta blocker for another condition? You can use this pain reliever safely .
  • Certain antidepressant medications , namely citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, trazodone and venlafaxine, and the adrenal hormones (corticosteroids) betamethasone, budesonide, cortisone, dexamethasone, prednisolone, prednisolone, methylpridol, prednisone, prednisone, prednisolprinnisone, hydrocortnisone This only applies if you are taking or being injected with these medicines.
    If you are taking antidepressant medications or adrenal cortex hormones, you are more likely to have celecoxib cause stomach side effects. Be extra aware of this and consult your doctor if you have stomach complaints. Usually the doctor will advise you to use a stomach protector as well, so that you avoid stomach upset. Consultation with your doctor if you need to.

Lithium , a medicine for manic depression. Celecoxib can increase the side effects of lithium. Your doctor will have the lithium level in the blood measured regularly and adjust the dose if necessary. Tell your doctor right away if you experience side effects of lithium, such as gastrointestinal upset, tremors, muscle weakness, muscle twitching, dizziness, sleepiness, drowsiness, confusion, decreased concentration, difficulty walking and speaking, and seizures. In warm weather, make sure you drink enough. Notify your doctor if you stop taking the painkiller . The lithium can then work less well. Even then, the doctor must check the lithium level in your blood more closely.

Methotrexate , a drug used for inflammatory diseases such as rheumatism or psoriasis , but also for cancer. Celecoxib can increase the side effects of methotrexate. Your doctor will check the amount of methotrexate in the blood more closely.

The immunosuppressive drug cyclosporine. The combination can be harmful to the kidneys. Your doctor will check your kidney function more closely if you are taking the painkiller for more than three days.

Not sure if any of the above interactions are of interest to you? Please contact your pharmacist or doctor.

Can I use this medicine if I am pregnant, planning to become or breastfeeding?

Pregnancy

  • Are you pregnant or do you want to become pregnant? It is better to use paracetamol for pain. Paracetamol is a safer pain reliever during pregnancy. Is paracetamol not working enough for your pain? Then talk to your doctor.
  • Do NOT use celecoxib for pain during the last 3 months of pregnancy. This drug is then harmful to the baby. The risk of birth defects in the baby is increased. It can also cause problems during delivery. Are you already using this drug? Then talk to your doctor. You may be able to switch to a different medication. A drug that is safe during pregnancy.
  • Would you like to use this drug during the first 6 months of pregnancy? Or if you want to get pregnant? Then talk to your doctor. Even then it is better NOT to use this medicine.
  • If your doctor considers this medicine to be necessary, for example, in a severe form of rheumatoid arthritis. Then the doctor will regularly check the baby and the amount of amniotic fluid.

Breast-feeding

  • You can safely usethis drugif you are breast-feeding. The drug passes into breast milk in small amounts, but is not harmful to the child.
  • Are you on prescription or over-the-counter medications? Would you like to help increase knowledge about medication use during pregnancy and breastfeeding? Then report your experience to pREGnant .

Can I use this medicine if my kidney or liver function is less?

Kidneys

  • Are your kidneys working less well? Then consult your pharmacist. A different medication may be more suitable. Or whether your kidney function should be checked more often.
  • Are you on dialysis? Then consult your pharmacist. On dialysis, this drug can cause more side effects. You may need to adjust your medication use.

Lever

  • Do you have cirrhosis of the liver? Consult with your doctor. You should NOT use this medication. In liver cirrhosis, this drug can cause more side effects. You may be able to switch to a different medication.

Can I use this medicine if I am seriously overweight or have had a stomach reduction?

Stomach reduction

Have you had a stomach reduction?

  • Then talk to your doctor or pharmacist. You should NOT use this medicine.
  • Little is known about the use of this medicine after gastric bypass surgery.
  • Therefore, it is not certain whether the stomach reduction has an influence on the effect and side effects of this drug.
  • You may be able to switch to a different medication.

Severe obesity

Are you seriously overweight?

  • Then talk to your doctor or pharmacist.
  • Little is known about the use of this drug for serious obesity.
  • Therefore, it is not certain whether being overweight has an influence on the effect and side effects of this drug.

can i stop taking celebrex suddenly?

You can stop taking this medicine at any time at once.

What is the brand name for celecoxib?

The active substance celecoxib is contained in the following products:

Do I need a prescription?

Celecoxib has been on the market internationally since 1998. It is available by prescription in capsules under the brand name Celebrex and as the unbranded Celecoxib.

Why is celecoxib banned?

In January, Public Citizen petitioned to have Bextra and Celebrex, two COX-2 inhibitors, removed from the market because they increase the risk of heart attacks. Today, the U.S. Food and Drug Administration (FDA) has called on Pfizer to pull Bextra from the shelves and place a warning on Celebrex.

what drugs contain celecoxib?