Cefpodoxime

The text below is about the active substance cefpodoxime.

what drug class is cefpodoxime?

The cefpodoxime is an antibiotic indicated mainly for the treatment of ENT infections and lung.

What is the mode of action of cefpodoxime?

Cefpodoxime is a third generation oral cephalosporin antibiotic in the beta lactam family . Its antibiotic mode of action involves blocking the synthesis of bacterial walls.

Spectrum of antibacterial activity

When different antibiotics are tested on bacteria, critical concentrations of antibiotics are obtained which separate the strains into three categories (sensitive, intermediate and resistant to the antibiotic) and thus give the spectrum of action of the treatment. In the case of this treatment, the critical concentrations are:

• Sensitive strains: concentrations <1 mg / l
• Intermediate strains: concentrations between 1 mg / l and 2 mg / l
• Resistant strains: concentrations> 2 mg / l

The prevalence of acquired resistance may vary depending on geography and time for some species. It is therefore useful to have information on the prevalence of local resistance, especially for the treatment of severe infections. These data can only provide guidance on the probabilities of the sensitivity of a bacterial strain to this antibiotic.

Sensitive species

• Gram-positive aerobes
  • Corynebacterium diphtheria
  • Streptococcus
  • Streptococcus pneumoniae (20 – 60%)
• Gram-negative aerobes
  • Branhamella catarrhalis
  • Citrobacter koseri
  • Escherichia coli
  • Haemophilus influenzae
  • Klebsiella (0 – 30%)
  • Neisseria gonorrhoeae
  • Pasteurella
  • Proteus mirabilis
  • Proteus vulgaris (29 – 38%)
  • Providencia
• Anaerobic
  • Fusobacterium (10 – 20%)
  • Prevotella (30 – 70%)
  • Propionibacterium acnes

Intermediate species

• Gram-positive aerobes
  • Staphylococcus meti-S

Resistant species

• Gram-positive aerobes
  • Enterococci
  • Listeria monocytogenes
  • Staphylococcus meti-R
• Gram-negative aerobes
  • Acinetobacter
  • Citrobacter freundii
  • Enterobacter
  • Morganella morganii
  • Pseudomonas
  • Serratia
• Anaerobic
  • Bacteroides fragilis
  • Clostridium
  • Peptostreptococcus

cefpodoxime indications

Cefpodoxime is indicated in adults for the following:

• Tonsillitis documented streptococcus beta-hemolytic
• Acute sinusitis
• Acute bronchial suppurations of subjects at risk (in particular alcoholics, tobacco users, subjects over 65 years old, etc.)
• Exacerbations of chronic obstructive pulmonary disease, especially during recurrent relapses or in at-risk subjects
• Bacterial lung disease, especially in at-risk subjects

Cefpodoxime is indicated in children in the following cases:

• Acute otitis media
• Documented strep throat a beta-hemolytic
• Sinusitis
• Lower respiratory infections

Cefpodoxime: all medicines containing the molecule