celestamine Uses, Dosage, Side Effects, Precautions & Warnings
Generic drug of the therapeutic class: Anti-inflammatory
active ingredients: Betamethasone , Dexchlorpheniramine
Table of Contents
what is celestamine ?
This medication contains a corticosteroid, betamethasone and an antihistamine, dexchlorphenamine.
What is the use of Celestamine and indication?
It is indicated in adults and children over 6 years of age for symptomatic treatment:
- seasonal or perennial allergic rhinitis after failure of an antihistamine alone or combined with local corticosteroid therapy,
- acute urticaria.
PRESENTATION (S) AVAILABLE FOR CELESTAMINE
1 polypropylene bottle (s) of 30 tablet (s)
| FEATURE | DESCRIPTION |
| Pharmaceutical class | not communicated |
| Active substance (s) | for one tablet: betamethasone (0.250 mg), dexchlorpheniramine maleate (2,000 mg) |
| General medicine | no |
| Pharmaceutical form | compressed |
| Route (s) of administration | oral |
| Selling price | unregulated price |
| Social security reimbursement rate | 0% |
| Laboratory (s) | Laboratory (s) manufacturer Celestamine |
| Conditions of issue | available by simple prescription |
how often celestamine (Dosage)?
As an indication, the usually effective dosage is:
- Adult and child over 12 years old : 3 or 4 tablets per day.
- Child from 6 to 12 years old : 1 tablet, morning and evening.
- The minimum effective dosage should always be sought, which can be lowered to 1 tablet every 2 days.
- The usual duration of treatment for acute urticaria will not exceed 10 days; also stopping treatment does not require a decrease.
celestamine Contraindications
Never take CELESTAMINE, tablet in the following cases:
- child under 6 years old (due to the risk of aspiration due to the tablet form).
- known allergy to the constituents of the product and in particular to corticosteroids and antihistamines.
- infections, certain evolving viral diseases (viral hepatitis, herpes, chickenpox, shingles),
- vaccination with live vaccines.
- certain untreated mental disorders,
- difficulty urinating from prostate or other causes,
- some forms of glaucoma (increased pressure inside the eye).
This medication is GENERALLY NOT RECOMMENDED, unless your doctor advises otherwise:
- in case of breastfeeding;
- combination with drugs which may cause certain heart rhythm disturbances.
IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.
How To Take celestamine ?
Method and route of administration
- ORAL
- The tablets are to be swallowed with a glass of water, preferably at the end of a meal.
Duration of treatment
- Observe the duration prescribed by your doctor.
how does celestamine work?
Pharmacotherapeutic group: Combination of a GLUCORCORTICOID FOR SYSTEMIC USE and an ANTIHISTAMINIC FOR SYSTEMIC USE (D. Dermatology) (R. Respiratory system), ATC code: R06AB52.
Betamethasone: synthetic corticosteroid used primarily for its anti-inflammatory effect.
Dexchlorphenamine: antihistamine H1, with a propylamine structure (substituted alkylamine), which is characterized by:
- A sedative effect marked at usual doses , of histaminergic origin and central adrenergic blocking agent,
- Anticholinergic effect causing peripheral side effects ,
- An adrenergic blocking effect device, which can resound in hemodynamically (risk of orthostatic hypotension).
Antihistamines have in common the property of opposing , by more or less reversible competitive antagonism, the effects of histamine, in particular on the skin, the vessels and the conjunctival, nasal, bronchial and intestinal mucous membranes.
How To Store celestamine ?
- Keep this medication out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiration date refers to the last day of that month.
- Store at a temperature not exceeding 25 ° C.
- Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.
What are the side effects of Celestamine?
Like all medicines, CELESTAMINE, tablet can cause side effects, although not everybody gets them.
- Certain side effects require IMMEDIATELY STOPPING TREATMENT AND TELL A DOCTOR:
- Allergic reactions:
- rash type (erythema, eczema, purpura, urticaria);
- angioedema (urticaria with sudden swelling of the face and neck which may cause difficulty in breathing);
- anaphylactic shock;
- Allergic reactions:
- Significant drop in white blood cells in the blood which may manifest as the onset or resurgence of a fever with or without signs of infections;
- Abnormal decrease in platelets in the blood which may result in bleeding from the nose or gums.
- Other side effects may occur:
- Drowsiness, decreased vigilance,
- Dry mouth, visual disturbances, urine retention, constipation, palpitations, change in blood pressure,
- Memory or concentration problems, dizziness (more common in the elderly),
- Excitement, motor incoordination, tremors,
- Confusion, hallucinations,
- Swelling and redness of the face, weight gain.
- Appearance of bruises,
- Bone fragility,
- Modification of certain biological parameters (salt, sugar, potassium), which may require a diet or additional treatment.
- Other side effects, much rarer, have been observed:
- Risk of insufficient secretion of the adrenal gland,
- Growth disorder in children,
- Menstruation disorders,
- Weak muscles.
If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.
Keep out of the reach and sight of children.
celestamine Interactions
Not recommended associations
Linked to the presence of betamethasone :
Medicines giving torsades de pointes (astemizole, bepridil, erythromycin IV, halofantrine, pentaminide, sparfloxacin, sultopride, terfenadine, vincamine):
- Use substances which do not have the disadvantage of causing torsades de pointes in the event of hypokalaemia.
CYP3A inhibitors
- Co-administration of CYP3A inhibitors, including cobicistat-containing products, is expected to increase the risk of systemic side effects. The combination should be avoided unless the benefits outweigh the increased risk of systemic side effects from corticosteroids; in this case, patients should be monitored for possible systemic side effects of corticosteroids.
Related to the presence of dexchlorphenamine :
Alcohol:
- Alcohol enhancement of the sedative effect of the antihistamine H1. Impaired vigilance can make driving and using machines dangerous.
- Avoid taking alcoholic drinks and other drugs containing alcohol.
Combinations subject to precautions for use
Linked to the presence of betamethasone :
Acetylsalicylic acid by system and by extrapolation from other salicylates
- Decrease in salicylemia during treatment with corticosteroids and risk of salicylate overdose after stopping it, by increased elimination of salicylates by corticosteroids.
- Adjust the doses of salicylates during the combination and after stopping treatment with corticosteroids.
Antiarrhythmics giving torsades de pointes (amiodarone, brétylium, disopyramide, quinidines, sotalol):
- Hypokalaemia is a contributing factor as is bradycardia and a pre-existing long QT space.
- Prevent hypokalaemia, correct it if necessary; monitor the QT space. In case of torsade, do not administer antiarrhythmic (electrosystolic training).
Oral anticoagulants
- Possible impact of corticosteroid therapy on the metabolism of the oral anticoagulant and that of coagulation factors.
- Haemorrhagic risk specific to corticosteroid therapy (digestive mucosa, vascular fragility) at high doses or in prolonged treatment longer than 10 days.
- When the association is justified, strengthen monitoring: biological control on the 8th day, then every 15 days during corticosteroid therapy and after stopping it.
Other hypokalaemic drugs (hypokalaemic diuretics alone or in combination, stimulant laxatives, amphotericin B IV):
- Increased risk of hypokalaemia by additive effect.
- Monitor serum potassium, correct it if necessary, especially in the case of digitalis therapy.
Digital
- Hypokalaemia promoting the toxic effects of digitalis.
- Monitor serum potassium, correct it if necessary and possibly ECG.
Heparin parenterally
- Aggravation by heparin of the hemorrhagic risk specific to corticosteroid therapy (digestive mucosa, vascular fragility) at high doses or in prolonged treatment longer than 10 days.
- The association must be justified, strengthen surveillance.
Enzyme inducers (carbamazepine, phenobarbital, phenitoin primidone, rifabutin, rifampicin):
- Decrease in plasma levels and the efficacy of corticosteroids by increasing their hepatic metabolism. The consequences are particularly important in Addisonians and in cases of transplantation.
- Clinical and biological monitoring, adjustment of the dosage of corticosteroids during the combination and after stopping the enzyme inducer.
Insulin, metformin, sulfonylureas
- Elevation of blood sugar with sometimes ketosis (decrease in tolerance to carbohydrates by corticosteroids). Warn the patient and reinforce blood and urine self-monitoring, especially at the start of treatment. If necessary, adjust the dosage of the antidiabetic medication during treatment with corticosteroids and after stopping it.
Isoniazid (described for prednisolone)
- Decreased plasma levels of isoniazid. Mechanism invoked: increased hepatic metabolism of isoniazid and decrease in that of glucocorticoids.
- Clinical and biological monitoring.
Gastrointestinal topicals (salts, oxides and hydroxides of magnesium, aluminum and calcium (described for prednisolone, dexamethasone)):
- Decreased digestive absorption of glucocorticoids.
- Take gastrointestinal topicals away from glucocorticoids (more than 2 hours if possible).
Associations to take into account
Linked to the presence of betamethasone :
Antihypertensives
- Decreased antihypertensive effect (hydrosodium retention of corticosteroids).
Interferon alpha
- Risk of inhibition of the action of interferon.
Live attenuated vaccines
- Risk of generalized, possibly fatal disease. This risk is increased in subjects already immunocompromised by the underlying disease.
- Use an inactivated vaccine when it exists (poliomyelitis).
Related to the presence of dexchlorphenamine :
Other central nervous system depressants (sedative antidepressants, barbiturates, benzodiazepines, clonidine and related drugs, hypnotics, morphine derivatives (analgesics and cough suppressants), methadone, neuroleptics, anxiolytics):
- Increase in central depression. Impaired vigilance can make driving and using machines dangerous.
Atropine and other atropine substances (imipramine antidepressants, antiparkinsonian anticholinergics, atropine antispasmodics, disopyramide, phenothiazine neuroleptics):
- Addition of atropine side effects such as urinary retention, constipation, dry mouth.
- Not applicable.
Effects on ability to Drive and use machines
- Attention is drawn, in particular, to vehicle drivers and machine users to the possibilities of drowsiness associated with the use of this medicine.
- This phenomenon is accentuated by the intake of alcoholic beverages or drugs containing alcohol.
Warnings and Precautions
Special warnings
BEFORE THE TREATMENT:
- Tell your doctor in case of recent vaccination, in case of digestive ulcer, colon diseases, recent surgery in the intestine, diabetes, high blood pressure, infection (especially history of tuberculosis) , liver failure, kidney failure, osteoporosis and myasthenia gravis (muscle disease with muscle fatigue).
- Tell your doctor if you are staying in the tropics, subtropics or southern Europe, due to the risk of parasitic disease.
- This medicine contains lactose. Its use is not recommended in patients with lactose intolerance (a rare hereditary disease).
DURING THE TREATMENT:
- As a precaution, limit contact with people with chickenpox or measles.
- Treatment of acute uterus will not exceed 10 days.
- If symptoms persist or worsen, CONSULT YOUR DOCTOR.
Precautions for use
During treatment, your doctor may advise you to follow a diet, especially low in salt.
In the event of long-term disease of the liver or kidneys, CONSULT YOUR DOCTOR so that he can adjust the dosage.
The taking of this drug requires a MEDICAL ADVICE, in the elderly:
- predisposed to constipation, dizziness or drowsiness,
- having prostate problems;
TELL YOUR DOCTOR before taking an antihistamine.
Refrain from taking alcoholic beverages or medication containing alcohol during this treatment.
IF IN DOUBT, DO NOT HESITATE TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.
PREGNANCY & BREAST-FEEDING & sports
Pregnancy
- It is possible to take this medicine during your pregnancy, as long as it is for a short time (a few days) and in the recommended doses.
- At the end of pregnancy, excessive use of this medication can cause harmful effects in the newborn. Therefore, always seek the advice of your doctor before using it.
Feeding with milk
- This medicine passes into breast milk. It is therefore not recommended for women who are breastfeeding.
- Ask your doctor or pharmacist for advice before taking any medicine.
USE OF CELESTAMINE BY ATHLETES
This specialty contains an active ingredient that can induce a positive reaction to the tests performed during doping controls.
What happens if I overdose from celestamine ?
Symptoms of dexchlorphenamine overdose:
- Convulsions (especially in infants and children)
- Impaired consciousness, coma;
A symptomatic treatment be instituted in a specialized environment.
What should I do if I miss a dose?
- Not applicable.
- Not applicable.
- Not applicable.
What happens if you stop taking celestamine ?
- Not applicable.
- Not applicable.
- Not applicable.
What is Forms and Composition ?
SHAPES and PRESENTATIONS
- Tablet (pink): Bottle of 30.
COMPOSITION
| p cp | |
| Betamethasone | 0.25 mg |
| Dexchlorpheniramine maleate | 2 mg |
- Excipients: gelatin, erythrosine (E127), lactose monohydrate, corn starch, magnesium stearate.
- Excipient with known effect: lactose monohydrate (172.173 mg / tab).
NOT’s
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general information:
- Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles
Additional information:
- General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.
Special warnings:
- For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.
Side effects:
- It treats possible side effects and drug interactions that require attention and its effect on continuous use.
- The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.