Analgesic Medicines – Drug Online https://edrug-online.com Medication Information Guide Mon, 23 Nov 2020 12:20:11 +0000 en-US hourly 1 https://wordpress.org/?v=5.6 aspirin vitamin c oberlin Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1588/aspirine-vitamin-c-oberlin.html https://edrug-online.com/1588/aspirine-vitamin-c-oberlin.html#respond Mon, 23 Nov 2020 12:20:11 +0000 https://edrug-online.com/?p=1588 ASPIRIN VITAMIN C OBERLINGeneric Drug Class Drug: Analgesics active ingredients: acetylsalicylic acid , ascorbic acid (E300) what is aspirin vitamin c oberlin ? This medicine contains aspirin and vitamin C. It is indicated in adults and children from 30 kg (approximately 9-15 years) for the symptomatic treatment of mild to moderate pain and / or feverish conditions. PRESENTATION (S) AVAILABLE FOR ASPIRIN […]]]> ASPIRIN VITAMIN C OBERLIN

Generic Drug Class Drug: Analgesics
active ingredients: acetylsalicylic acid , ascorbic acid (E300)

what is aspirin vitamin c oberlin ?

This medicine contains aspirin and vitamin C.

It is indicated in adults and children from 30 kg (approximately 9-15 years) for the symptomatic treatment of mild to moderate pain and / or feverish conditions.

PRESENTATION (S) AVAILABLE FOR ASPIRIN 500 MG VITAMIN C OBERLIN

2 presentations are available for this medication:

  • 2 polypropylene tube (s) of 10 tablet (s)
  • 2 polypropylene tube (s) of 15 tablet (s)
FEATURE DESCRIPTION
Pharmaceutical class pain relievers
Active substance (s) for one tablet: acetylsalicylic acid (0.50000 g), ascorbic acid (0.20000 g)
General medicine no
Pharmaceutical form breakable effervescent tablet
Route (s) of administration oral
Selling price unregulated price
Social security reimbursement rate 0%
Laboratory (s) Manufacturer laboratory (ies) Aspirin 500 mg vitamin C oberlin
Conditions of issue available without prescription

 

aspirin vitamin c oberlin Dosage

Mild to moderate pain and / or feverish conditions :

  • Reserved for adults and children from 30 kg (approximately 9 to 15 years).
  • In children, it is imperative to respect the dosages defined according to the weight of the child and to choose a suitable presentation. The approximate ages according to weight are given for information.
  • The recommended daily dose of acetylsalicylic acid is approximately 60 mg / kg / day, divided into 4 or 6 divided doses, i.e. approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours.
  •  For children weighing 30 to 40 kg (approximately 9 to 13 years old), the dosage is 1 effervescent tablet per dose, to be renewed if necessary after 6 hours, without exceeding 4 tablets per day.
  •  For children weighing 41 to 50 kg (approximately 12 to 15 years old), the dosage is 1 effervescent tablet per dose, to be renewed if necessary after 4 hours, without exceeding 6 tablets per day .

For adults and children weighing more than 50 kg (from about 15 years old):

  • The maximum recommended daily dose is 3 g of aspirin, or 6 tablets per day.
  • The usual dosage is 1 effervescent tablet of 500 mg, to be renewed if necessary after at least 4 hours. In case of more intense pain or fever, 2 tablets of 500 mg, to be renewed if necessary after at least 4 hours, without exceeding 6 effervescent tablets per day .

For the elderly:

  • The maximum recommended daily dosage is 2 g of aspirin, or 4 effervescent tablets per day.
  • The usual dosage is 1 effervescent tablet of 500 mg, to be renewed if necessary after at least 4 hours. In case of more intense pain or fever, 2 tablets of 500 mg, to be renewed if necessary after a minimum of 4 hours, without exceeding 4 effervescent tablets per day .

Frequency of administration:

  • Systematic catches prevent oscillations of pain or fever.
  • The catches must be regularly spaced, including at night , preferably 6 hours , and at least 4 hours: comply with the dosage specified above.

Duration of the treatment:

  • The patient should be instructed not to use acetylsalicylic acid for more than 3 days in case of fever and 5 days in case of pain without the advice of a doctor or dentist.

aspirin vitamin c oberlin Contraindications

You should not take ASPIRINE 500 mg VITAMIN C OBERLIN, effervescent tablet, in the following cases:

  • allergy to aspirin or a related drug (especially nonsteroidal anti-inflammatory drugs) or to any of the other ingredients,
  • history of asthma caused by the administration of aspirin or a related drug (especially nonsteroidal anti-inflammatory drugs),
  • beyond 5 months of pregnancy (24 weeks of amenorrhea) for doses greater than 100 mg per day,
  • ulcer of the stomach or duodenum in progress,
  • haemorrhagic disease or risk of bleeding,
  • severe liver disease,
  • severe kidney disease,
  • severe heart disease,
  • kidney stone, due to the presence of vitamin C for doses greater than 1 g per day,
  • treatment with methotrexate used at doses greater than 20 mg / week and when aspirin is used in high doses as anti-inflammatory drugs (≥ 1 g per dose and / or ≥ 3 g per day) especially in the treatment of fever or pain (≥ 500 mg per dose and / or <3 g per day).

In case of doubt, it is essential to seek the advice of your doctor or pharmacist.

How To Store aspirin vitamin c oberlin ?

  • Keep out of the reach and sight of children.
  • Do not use this medicine after the expiry date which is stated on the package. The expiration date refers to the last day of that month.
  • No special storage conditions.
  • Do not throw away any medicine via wastewater or household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

aspirin vitamin c oberlin Side Effects

Like all medicines, ASPIRINE 500 mg VITAMIN C OBERLIN, scored effervescent tablet can cause side effects, although not everybody gets them.

Related to aspirin:

  • You should stop treatment immediately and tell your doctor in the following cases:
    • digestive hemorrhages. These are all the more frequent as the dosage used is high,
    • allergic reactions such as rash, asthma attack, angioedema (facial hives with difficulty in breathing),
    • ringing in the ears, sensation of hearing loss, headache, dizziness: these signs usually indicate an overdose of aspirin,
    • Reye’s syndrome (appearance of disturbance of consciousness or behavior and of vomiting) in a child with a viral illness and receiving aspirin.
  • Notify your doctor in case of abdominal pain, nosebleeds or gums. Stomach ulcers have been reported. Linked to vitamin C: In doses greater than 1g / day in vitamin C, possibility of:
  • digestive disorders (heartburn, diarrhea)
  • urinary disorders (formation of kidney stones).

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

aspirin vitamin c oberlin Interactions

When aspirin is used in high doses as an anti-inflammatory (≥ 1 g per dose and / or ≥ 3 g per day), in particular in the treatment of rheumatic conditions, or in the treatment of fever or pain (≥ 500 mg per dose and / or <3 g per day), this medicinal product must not be used in combination:

  • with methotrexate used at doses greater than 20 mg / week,
  • with oral anticoagulants and in the event of a history of stomach or duodenal ulcer,

This drug should be avoided in combination with:

  • oral anticoagulants, when aspirin is used in high doses for the treatment of fever or pain (≥ 500 mg per dose and / or <3 g per day) and in the absence of a history of ulcer stomach or duodenum,
  • oral anticoagulants, when aspirin is used at low doses as an antiplatelet agent (50 to 375 mg per day) and in the event of a history of stomach or duodenal ulcer,
  • nonsteroidal anti-inflammatory drugs, when aspirin is used in high doses as anti-inflammatory drugs (≥ 1 g per dose and / or ≥ 3 g per day), in particular in the treatment of rheumatic diseases, or in the treatment of fever or pain (≥ 500 mg per dose and / or <3 g per day),
  • glucocorticoids (except hydrocortisone as a replacement therapy), when aspirin is used in high doses as an anti-inflammatory (≥ 1 g per dose and / or ≥ 3 g per day), in particular in the treatment of rheumatic conditions,
  • heparins used in curative doses and / or in subjects over 65 years of age, when aspirin is used in high doses as an anti-inflammatory (≥ 1 g per dose and / or ≥ 3 g per day), particularly in the treatment of rheumatic conditions, or in the treatment of fever or pain (≥ 500 mg per dose and / or <3 g per day,
  • medicines used in the treatment of gout,
  • clopidogrel,
  • pemetrexed in subjects with poor to moderate renal function,
  • ticlopidine.

In order to avoid possible interactions between several drugs, you should systematically report any other current treatment to your doctor or pharmacist.

Drive and use machines

Warnings and Precautions

 

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

Doses between 100 and 500 mg per day:

  • There is insufficient clinical experience with the administration of doses between 100 mg and 500 mg per day. Accordingly, the recommendations below for doses above 500 mg per day apply to these doses.

Doses greater than or equal to 500 mg per day:

  • Inhibition of prostaglandin synthesis by NSAIDs may affect the course of pregnancy and / or the development of the embryo or fetus.

Risks associated with use during the 1 st  trimester:

  • Data from epidemiological studies suggest an increased risk of miscarriage, heart defects and gastroschisis, after treatment with a prostaglandin synthesis inhibitor in early pregnancy. The absolute risk of cardiovascular malformation has decreased from less than 1% in the general population to approximately 1.5% in people exposed to NSAIDs. The risk appears to increase with the dose and duration of treatment.
  • In animals, administration of a prostaglandin synthesis inhibitor has been shown to cause increased pre- and post-implantation loss and increased embryo-fetal lethality. In addition, a higher incidence of certain malformations, including cardiovascular, has been reported in animals given a prostaglandin synthesis inhibitor during the organogenesis phase of gestation.

Risks associated with the use from the 12 th  week of gestation until birth:

From the 12 th  week of gestation until birth, all NSAIDs, by inhibiting prostaglandin synthesis, may expose the fetus to renal functional impairment  :

  • in utero which can be observed from 12 weeks of amenorrhea (initiation of fetal diuresis): oligoamnios (most often reversible when treatment is stopped), even anamnios in particular during prolonged exposure;
  • at birth, renal failure (reversible or not) may persist, in particular in the event of late and prolonged exposure (with a risk of severe delayed hyperkalaemia).

Risks associated with the use beyond the 24 th  week of gestation until birth:

  • Beyond the 24 th  week of amenorrhea, NSAIDs may expose the fetus to cardiopulmonary toxicity (premature closure of the ductus arteriosus and pulmonary hypertension). Constriction of the ductus arteriosus can occur from the age of 5 months and can lead to fetal or neonatal right heart failure or even fetal death in utero. This risk is all the more important as the catch is close to the term (less reversibility). This effect exists even for a one-time take.

At the end of pregnancy, the mother and the newborn may present:

  • prolongation of bleeding time due to anti-aggregating action which may occur even after administration of very low doses of drug;
  • inhibition of uterine contractions leading to delayed term or prolonged childbirth.

Consequently, for doses greater than 100 mg / day:

  • Unless absolutely necessary, this medication should not be used in a woman planning to become pregnant or during the first 5 months of pregnancy (first 24 weeks of amenorrhea). If this medicine is given to a woman who wants to be pregnant or less than 6 months pregnant, the dose should be as low as possible and the duration of treatment as short as possible. Prolonged intake is strongly discouraged.
  • From the beginning of the 6 th  month (beyond 24 weeks): all this medication, even punctual, is cons-indicated. An inadvertent intake from this date justifies cardiac and renal, fetal and / or neonatal monitoring depending on the term of exposure. The duration of this monitoring will be adapted to the elimination half-life of the molecule.

Feeding with milk

  • As acetylsalicylic acid passes into breast milk, this medication is not recommended during breast-feeding.

Fertility

  • Like all NSAIDs, the use of this drug may temporarily impair female fertility, by affecting ovulation; it is therefore not recommended for women wishing to conceive a child. In women having difficulty conceiving or having fertility tests, discontinuation of treatment should be considered.

 

What happens if I overdose from aspirin vitamin c oberlin ?

Linked to aspirin:

  • Intoxication is to be feared in the elderly and especially in young children (therapeutic overdose or frequent accidental poisoning) where it can be fatal.

Symptoms :

  • Moderate poisoning: ringing in the ears, feeling of hearing loss, headache, dizziness are signs of overdose and can be controlled by reducing the dosage.
  • Severe poisoning: in children, overdose can be fatal from 100 mg / kg in a single dose.
    The symptoms are: fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular collapse, respiratory failure, severe hypoglycemia.

Emergency driving:

  • Immediate transfer to a specialized hospital environment.
  • Digestive decontamination and administration of activated charcoal.
  • Control of acid base balance.
  • Alkaline diuresis to obtain a urinary pH between 7.5 and 8, possibility of hemodialysis in severe intoxications.
  • Symptomatic treatment.

Linked to vitamin C:

  • At doses greater than 1 g / day in vitamin C, possibility of: digestive disorders (heartburn, diarrhea, abdominal pain), urinary disorders (oxalic, cystine and / or uric lithiasis).
  • At doses greater than 2 g / day in vitamin C, ascorbic acid may interfere with the following biological tests: determinations of creatinine and blood and urine glucose (control of diabetes by glucose-oxidase test).
  • At doses greater than 3 g / day in vitamin C, risk of hemolysis in subjects deficient in G6PD.

What should I do if I miss a dose?

  • Do not take a double dose to make up for the single dose you forgot to take.

What happens if you stop taking aspirin vitamin c oberlin ?

  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

SHAPES and PRESENTATIONS
  • Effervescent tablet (white):   Box of 2 tubes of 10.
COMPOSITION
  p cp
Acetylsalicylic acid  330 mg
Ascorbic acid  200 mg
  • Excipients: sodium bicarbonate, anhydrous citric acid, sodium benzoate (E211), povidone.
  • Excipients with known effect: sodium (485 mg / tab efferv), sodium benzoate (E211) (48 mg / tab efferv).

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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temgesic solution for injection Uses, Dosage, Side Effects& Precautions https://edrug-online.com/1844/temgesic-injection.html https://edrug-online.com/1844/temgesic-injection.html#respond Sun, 22 Nov 2020 09:38:36 +0000 https://edrug-online.com/?p=1844 temgesic injectionTEMGESIC 0.3 mg / ml, solution for injection >> Generic drug of the Therapeutic class: Analgesics active ingredients: Buprenorphine what is temgesic 0.3 mg/ml medication used for and indication? This medicine is reserved for situations requiring rapid and effective relief of severe pain, for example during surgery. PRESENTATION (S) AVAILABLE FOR TEMGESIC 0.3 MG / ML 4 […]]]> temgesic injection

TEMGESIC 0.3 mg / ml, solution for injection >> Generic drug of the Therapeutic class: Analgesics
active ingredients: Buprenorphine

what is temgesic 0.3 mg/ml medication used for and indication?

This medicine is reserved for situations requiring rapid and effective relief of severe pain, for example during surgery.

PRESENTATION (S) AVAILABLE FOR TEMGESIC 0.3 MG / ML

4 presentations are available for this drug:

  • 2 ampoule (s) of 1 ml
  • 5 ampoule (s) of 1 ml
  • 10 ampoule (s) of 1 ml
  • 25 ampoule (s) of 1 ml
FEATURE DESCRIPTION
Pharmaceutical class not communicated
Active substance (s) buprenorphine (hydrochloride)
General medicine no
Pharmaceutical form injectable solution
Route (s) of administration intramuscular, intrathecal, intravenous, epidural, subcutaneous
Selling price unregulated price
Social security reimbursement rate 0%
Laboratory (s) Manufacturer (s) Temgesic 0.3 mg / ml
Conditions of issue available by simple prescription

temgesic injection dosage

  • The dosage is determined individually for each patient.
  • The usual dose, subcutaneously, intravenously or intramuscularly, for an adult weighing 70 kg is one ampoule, or 0.3 mg, every 6 to 8 hours.
  • In elderly or frail patients, a lower dosage is sometimes sufficient.
  • If you have the impression that the effect of TEMGESIC 0.3 mg / ml 0.3 mg / ml, solution for injection is too strong or too weak, talk to your doctor or pharmacist.
  • STRICTLY COMPLY WITH THE MEDICAL PRESCRIPTION.

temgesic 0.3 mg/ml Contraindications

Never use TEMGESIC 0.3 mg / ml, solution for injection in the following cases:

  • known allergy to buprenorphine or to any of the ingredients of this medication,
  • severe respiratory failure,
  • severe liver disease,
  • acute alcohol poisoning and alcohol withdrawal syndrome (delirium tremens),
  • treatment with other morphine analgesics,
  • children under 15.

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

How do you take Temgesic injection ?

Method and route of administration

  • Parenteral route (intramuscular, intravenous or subcutaneous).
  • Medullary route.

Frequency of administration

STRICTLY COMPLY WITH THE MEDICAL PRESCRIPTION.

Duration of treatment

  • The duration of treatment are determined individually for each patient.
  • STRICTLY COMPLY WITH THE MEDICAL PRESCRIPTION.

How To Store temgesic 0.3 mg/ml ?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the carton and bulb, EXP. The expiration date refers to the last day of that month.
  • After opening / reconstitution / dilution: the product should be used immediately.
  • Store at a temperature not exceeding 30 ° C.
  • Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

temgesic 0.3 mg/ml Side Effects

Like all medicines, TEMGESIC 0.3 mg / ml, solution for injection can cause side effects, although not everybody gets them.

The following side effects have been observed:

  • Common side effects (1% -10%): constipation, nausea, vomiting, insomnia, headache, malaise and dizziness, fatigue, drowsiness, drop in blood pressure when changing from lying or sitting to lying down or sitting down standing, sweating.
  • Rare side effects (0.01% -0.1%): respiratory failure, hallucinations, hepatitis (liver damage) with jaundice.
  • Other reported side effects: hypersensitivity reactions (allergy), such as rash, pruritus (itching), bronchospasm (bronchial spasm), angioedema (swelling of the face and neck which may cause breathing difficulties) and anaphylactic shock ( severe generalized allergic reaction).

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

temgesic injectionS Interactions

 

Effects on ability to Drive and use machines

Attention is drawn, especially among vehicle drivers and users of machines, to the risk of drowsiness associated with the use of this medication.

Warnings and Precautions

Special warnings

  • This drug should not be used in the withdrawal of drug addicts. Indeed, the conditions of use and the dosage in this indication are not suitable.
  • The possibility of psychological and physical dependence during prolonged treatments is possible with this drug.
  • The risk of misuse also exists, albeit low.
  • Use in patients with morphine or heroin dependence as well as in subjects who have recently been treated with other morphine drugs should be cautious due to unforeseeable resulting effects (synergy or antagonism).
  • The same applies when another morphine is used during treatment with buprenorphine.

Precautions for use

  • In case of surgery, tell the anesthesiologist to take this medication.
  • IN CASE OF DOUBT, DO NOT HESITATE TO ASK FOR THE ADVICE OF YOUR DOCTOR OR YOUR PHARMACIST.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • Occasional use of this medication during pregnancy is possible

Feeding with milk

  • It is best to avoid breast-feeding while taking this medicine.
  • Ask your doctor or pharmacist for advice before taking any medicine.

What happens if I overdose from temgesic injection ?

  • An overdose of buprenorphine requires the patient to be placed under medical supervision and possibly emergency treatment in hospital.
  • Immediately consult your doctor or pharmacist.

What should I do if I miss a dose?

If you forget to use TEMGESIC 0.3 mg / ml, solution for injection:

  • Ask the prescribing doctor for his opinion.

What happens if you stop taking temgesic 0.3 mg/ml injection?

If you stop taking TEMGESIC 0.3 mg / ml, solution for injection:

  • Abrupt discontinuation of treatment may lead to the appearance of a withdrawal syndrome.
  • If you have further questions on the use of this medicine, ask your doctor or pharmacist for more information.

What is  Forms and Composition ?

Appearance and shape

Lack of information in the MA.

1 ml in ampoule. Box of 2 bulbs.

Other shapes

COMPOSITION

Active substance

Buprenorphine hydrochloride corresponding to buprenorphine base: 0.3 mg

For a 1 ml ampoule.

Other components

Glucose anhydrous, hydrochloric acid, water for injections.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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Actron effervescent tablet Uses, Dosage, Side Effects& Precautions https://edrug-online.com/1859/actron.html https://edrug-online.com/1859/actron.html#respond Wed, 18 Nov 2020 10:35:27 +0000 https://edrug-online.com/?p=1859 Actron effervescent tabletACTRON, effervescent tablet, box of 10 heat-sealed films of 2 >> Generic drug of the Therapeutic class: Analgesics active ingredients: Acetylsalicylic acid , Paracetamol , Caffeine what is actron tablet ? This medicine contains two analgesics: aspirin and paracetamol and caffeine. What is Actron used for and indication? It is indicated in diseases with pain […]]]> Actron effervescent tablet

ACTRON, effervescent tablet, box of 10 heat-sealed films of 2 >> Generic drug of the Therapeutic class: Analgesics

active ingredients: Acetylsalicylic acid , Paracetamol , Caffeine

what is actron tablet ?

This medicine contains two analgesics: aspirin and paracetamol and caffeine.

What is Actron used for and indication?

It is indicated in diseases with pain and fever such as headache, flu-like symptoms, toothache and muscle aches in adults.

PRESENTATION (S) AVAILABLE FOR ACTRON

4 presentations are available for this drug:

  • heat-sealed film (s) polyethylene aluminum PAM-ethylene (SURLYN) of 10 tablet (s)
  • heat-sealed film (s) polyethylene aluminum PAM-ethylene paper (SURLYN) of 20 tablet (s)
  • heat-sealed film (s) polyethylene aluminum PAM-ethylene paper (SURLYN) of 30 tablet (s)
  • heat-sealed film (s) polyethylene aluminum PAM-ethylene paper (SURLYN) of 40 tablet (s)
FEATURE DESCRIPTION
Pharmaceutical class not communicated
Active substance (s) for one tablet: acetylsalicylic acid (0.267 g), caffeine (0.040 g), paracetamol (0.133 g)
General medicine no
Pharmaceutical form effervescent tablet
Route (s) of administration oral
Selling price unregulated price
Social security reimbursement rate 0%
Laboratory (s) Laboratory (ies) manufacturer Actron
Conditions of issue available without prescription

actron tablet Dosage

FOR ADULTS ONLY

  • The catches should be spaced at least 4 hours apart.
    • Adult: As an indication: 1 tablet to be renewed if necessary after 4 hours. In case of more intense pain, 2 tablets per dose. Do not exceed the dose of 7 tablets per day. The maximum daily dosage of aspirin and paracetamol is 3 g.
    • Elderly subject: As an indication: 1 tablet to be renewed if necessary after 4 hours. In case of more intense pain, 2 tablets per dose. Do not exceed the dose of 5 tablets per day. The maximum daily dosage of aspirin and paracetamol is 2 g.

actron tablet Contraindications

Never take ACTRON, effervescent tablet in the following cases:

  • child under 15 due to the presence of caffeine.
  • from the 6 th month of pregnancy,
  • allergy to aspirin, paracetamol or a related drug (especially non-steroidal anti-inflammatory drugs),
  • severe liver disease,
  • ulcer of the stomach or duodenum in progress,
  • haemorrhagic disease or risk of haemorrhage,
  • in case of treatment by:
    • methotrexate (doses greater than 15 mg per week),
    • oral anticoagulants when aspirin is prescribed in high doses (greater than or equal to 3 g per day).

This medication SHOULD NOT BE USED GENERALLY, unless your doctor advises otherwise,

  • in case of breastfeeding,
  • in case of treatment by:
    • oral anticoagulants (for aspirin doses of less than 3 g per day),
    • other non-steroidal anti-inflammatory drugs (for high doses of aspirin or greater than or equal to 3 g per day),
    • injectable heparins,
    • uricosurics (gout medications)
    • ticlopidine,
    • enoxacin.

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

How To Take Actron ?

Administration mode

ORAL

  • Drink immediately after complete dissolution of the effervescent tablet in a glass of water, sweetened or not, milk or fruit juice.

Frequency of administration

  • The catches distributed throughout the day make it possible to avoid peaks of fever or pain. They should be spaced at least 4 hours apart.
  • In the event of serious kidney disease (severe renal failure), the catches should be spaced at least 8 hours apart.
  • Due to the presence of caffeine, avoid taking this medication at the end of the day.

Duration of the treatment

  • Do not exceed 3 days of treatment in case of fever, nor 5 days of treatment in case of pain without the advice of your doctor.
  • DO NOT USE ON AN EXTENDED BASIS WITHOUT MEDICAL ADVICE.

How To Store Actron effervescent ?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the carton. The expiration date refers to the last day of that month.
  • Store at a temperature not exceeding 25 ° C.
  • Do not throw away any medicine via wastewater or household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

Actron Side Effects

Like all medicines, ACTRON, effervescent tablet can cause side effects, although not everybody gets them:

You should STOP YOUR TREATMENT IMMEDIATELY and notify your doctor in the following cases:

  • allergic reactions such as rash, asthma attack, angioedema (facial hives with difficulty breathing),
  • haemorrhage (discharge of blood through the mouth or in the stool, stool color black). This is all the more frequent the higher the dosage used.
  • ringing in the ears, sensation of hearing loss, headache: these usually indicate an overdose of aspirin.

Notify your doctor in case of abdominal pain, nosebleeds, gums.

Possibility of excitement, insomnia and palpitations due to the presence of caffeine.

Stomach ulcers have been reported.

Exceptionally, an abnormally low level of certain elements of the blood (platelets) appears, which can be manifested by bleeding from the nose or gums. This requires checking the blood work.

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Actron Interactions

<No interaction studies have been performed.>

  • The following interactions are linked to the presence of aspirin, caffeine and paracetamol.

Contraindicated associations

Related to the presence of aspirin:

Oral anticoagulants

  • Acetylsalicylic acid, at analgesic or antipyretic doses (≥ 500 mg per dose and / or <3 g / day) and in the event of a history of gastro-duoenal ulcer: increased risk of bleeding, especially in the event of gastrointestinal ulcer. duodenal.

 Methotrexate used at doses greater than 20 mg / week

  • Increase in toxicity, especially haematological, of methotrexate (decrease in its renal clearance of methotrexate by acetylsalicylic acid).

Not recommended associations

Related to the presence of aspirin:

Anagrelide

  • Increase in hemorrhagic events.

Oral anticoagulants, in the absence of a history of peptic ulcer:

  • Acetylsalicylic acid at analgesic or antipyretic doses (≥ 500 mg per dose and / or <3 g / day): increased risk of bleeding.
  • Low-dose salicylates: need to be monitored, if necessary, in particular the bleeding time.

NSAIDs

(Including salicylates from 3 g / day in adults)

  • Increase in the ulcerogenic and digestive hemorrhagic risk.

Clopidogrel

  • Increase in hemorrhagic risk by addition of antiplatelet activities.

Defibrotide

  • Increased risk of bleeding.

Low molecular weight and related heparins and unfractionated heparins (curative doses and / or elderly patients)

  • Acetylsalicylic acid at analgesic or antipyretic doses (≥ 500 mg per dose and / or <3 g / day): Increased risk of hemorrhage (inhibition of platelet function and aggression of the gastroduodenal mucosa by acetylsalicylic acid).
  • Use another analgesic or antipyretic.

Pemetrexed, in patients with poor to moderate renal function (creatinine clearance between 45 ml / min and 80 ml / min)

  • Risk of increased toxicity of pemetrexed (decrease in its renal clearance by acetylsalicylic acid at anti-inflammatory doses).

Ticagrelor

  • Increase in hemorrhagic risk by addition of antiplatelet activities.

Ticlopidine

  • Increase in hemorrhagic risk by addition of antiplatelet activities. If the association cannot be avoided, close clinical monitoring.

Uricosurics

  • Decrease in the uricosuric effect by (competition for the elimination of uric acid in the renal tubules).
  • Use another pain reliever.

Related to the presence of caffeine:

Enoxacin

  • Increase in plasma caffeine concentrations which may lead to excitations and hallucinations, due to a decrease in its hepatic metabolism.

Combinations subject to precautions for use

Related to the presence of aspirin:

Angiotensin II receptor antagonists

For analgesic or antipyretic doses of aspirin (doses ≥ 500 mg per dose and / or <3 g per day):

  • Acute renal failure in dehydrated patients, by decrease in glomerular filtration secondary to a decrease in the synthesis of renal prostaglandins. Moreover, reduction of the antihypertensive effect.
  • Hydrate the patient and monitor renal function at the start of treatment.

 Antidiabetics: insulins, chlorpropamide

  • Enhancement of the hypoglycaemic effect by high doses of acetylsalicylic acid (hypoglycaemic action of acetylsalicylic acid and displacement of the sulfonylurea from its binding to plasma proteins).
  • Warn the patient and reinforce blood glucose self-monitoring.

Corticosteroids (gluco-) (systemic route)

  • Decrease in salicylemia during treatment with corticosteroids and risk of salicylate overdose after stopping them (increased elimination of salicylates by corticosteroids).
  • Adjustment of the doses of salicylates during the combination and after stopping treatment with glucocorticoids.

Diuretics, ACE inhibitors

  • For acetylsalicylic acid at anti-inflammatory and analgesic or antipyretic doses: acute renal failure in dehydrated patients by reduction in glomerular filtration secondary to a reduction in the synthesis of renal prostaglandins. Moreover, reduction of the antihypertensive effect.
  • Hydrate the patient and; Look at the kidney function at the start of the treatment.

Interferon alfa

  • Risk of inhibition of the action of interferon.
  • Preferably use a non-salicylated antipyretic analgesic.

Methotrexate used at doses less than or equal to 15 mg / week

  • Increase in toxicity, in particular haematological methotrexate (decrease in its renal clearance by acetylsalicylic acid.
  • Weekly control of the blood count during the first weeks of the association.
  • Increased monitoring in the event of deterioration (even slight) of renal function, as well as in the elderly.

Pemetrexed, in patients with normal renal function

  • Risk of increased toxicity of pemetrexed (decrease in its renal clearance by acetylsalicylic acid at anti-inflammatory doses).
  • Biological monitoring of the renal function.

Pentoxifylline

  • Increased risk of bleeding.
  • Strengthen clinical monitoring and more frequent monitoring of bleeding time.

Linked to the presence of paracetamol:

Antivitamin K

  • Risk of an increase in the effect of the antivitamin K and the risk of bleeding if paracetamol is taken at maximum doses (4 g / d) for at least 4 days.
  • More frequent control of the INR. Possible adjustment of the dose of the antivitamin K during treatment with paracetamol and after its discontinuation.

Related to the presence of caffeine:

Dipyridamole

  • With injectable dipyridamole: reduction of the vasodilator effect of dipyridamole by caffeine.
  • Interrupt caffeine therapy at least 5 days prior to myocardial imaging with dipyridamole and avoid the consumption of coffee, tea, chocolate or cola within 24 hours of the test.

Stiripentol

  • Possible increase in plasma concentrations of caffeine, with risk of overdose, by inhibition of its hepatic metabolism.
  • Clinical monitoring and possible adjustment of the caffeine dosage.

Associations to take into account

Related to the presence of aspirin:

Deferasirox

  • Increased risk of gastrointestinal ulcer and heporrhagic disease.

Intrauterine device

  • (Controversial) risk of decreased efficacy of the intrauterine device.

Glucocorticoids (except hydrocortisone)

  • Increased risk of hemorrhage.

Low molecular weight and related heparins and unfractionated heparins (preventive doses)

  • The combined use of drugs that act at various levels of hemostasis increases the risk of bleeding. Thus, in subjects under 65 years of age, the combination of heparin at preventive doses, or related substances, with acetylsalicylic acid, whatever the dose, must be taken into account while maintaining clinical monitoring and possibly biological.

Selective serotonin reuptake inhibitors

  • Increased risk of hemorrhage.

Thrombolytics

  • Increased risk of bleeding,

Gastrointestinal topicals: salts, oxides and hydroxides of magnesium, aluminum and calcium

  • Increased renal excretion of salicylates by alkalinization of urine.

Linked to the presence of caffeine:

Ciprofloxacin, norfloxacin

  • Increase in plasma concentrations of caffeine, by decrease in its hepatic metabolism.

Lithium

  • In the event of sudden cessation of consumption of coffee or drugs containing caffeine, risk of increased blood lithium.

Mexiletine

  • Increase in plasma caffeine concentrations, by inhibition of its hepatic metabolism by mexiletine.

Other interactions linked to the presence of paracetamol:

  • Drugs leading to delayed gastric emptying may lead to slower absorption of paracetamol and thus to a delayed onset of action.
  • Medicines leading to accelerated gastric emptying (eg metoclopramide), can lead to faster absorption of paracetamol and therefore to a faster onset of action.
  • The concomitant use of drugs which induce an induction of hepatic enzymes, for example certain hypnotics and antiepileptic drugs (phenobarbital, phenytoin, carbamazepine etc.) or rifampicin can lead to liver damage, even at doses of paracetamol which would otherwise be without risk. In case of excessive alcohol consumption, taking paracetamol, even in therapeutic doses, can lead to liver damage.
  • The effects of the following drugs are intensified: Combination with chloramphenicol may prolong its half-life and thus potentially increase its toxicity.
  • Tropisetron and granisetron, which are 5HT-3 serotonin antagonists, can completely inhibit the analgesic effect of paracetamol due to pharmacodynamic interaction.
  • Concomitant use of paracetamol and AZT (zidovudine) increases the tendency towards a reduction in the number of white blood cells (neutropenia). Also paracetamol should not be taken in combination with AZT, except on medical advice.
  • It is best to avoid continuous treatment combined with more than one pain reliever; there is little evidence of additional benefit to the patient, and the incidence of side effects is generally additive.

Effects on ability to Drive , use machines &ATHLETES

The attention of athletes is drawn to the fact that this medication contains an active principle which can induce a positive reaction to tests carried out during doping controls.

Warnings and Precautions

Special warnings

If the pain persists for more than 5 days, the fever for more than 3 days or if they worsen, do not continue the treatment without the advice of your doctor or pharmacist.

In case of overdose or mistakenly taking too high a dose, contact a doctor immediately.

Reye’s Syndromes (a rare but very serious disease mainly combining neurological disorders and liver damage) have been observed in children with viral illnesses and receiving aspirin.

Consequently :

  • in the event of a viral disease, such as chickenpox or an episode of influenza-like illness: do not administer aspirin to a child without the advice of a doctor,
  • If a child develops consciousness or behavior and vomits in taking aspirin, contact a doctor immediately.

Precautions for use

Before taking aspirin, it is necessary to CONSULT YOUR DOCTOR in the event of:

  • of gout.
  • digestive history: haemorrhage, old ulcer of the stomach or duodenum,
  • kidney or liver disease,
  • asthma: the occurrence of an asthma attack in some subjects may be linked to allergy to aspirin or NSAIDs; in this case this drug is contraindicated.
  • important periods or contraception by IUD.

Aspirin increases the risk of bleeding from very low doses, even when the intake is several days old. TELL YOUR ATTENDING DOCTOR, SURGEON, ANESTHESIST OR YOUR DENTIST, in the event that a surgical procedure, even minor, is considered.

This medicine contains sodium. This medicine contains 440 mg of sodium per tablet. To be taken into account in patients controlling their dietary sodium intake.

This medicine can cause insomnia, it should not be taken at the end of the day.

IF IN DOUBT, DO NOT HESITATE TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • During the FIRST 5 MONTHS of your pregnancy, your doctor may, if necessary, prescribe this medication to you on an ad hoc basis.
  • FROM th MONTH OF PREGNANCY, you should IN NO EVENT take OF YOURSELF this drug because its effect on your child can have serious consequences, particularly vascular and renal level, even with only once and even when the child is at term.

Feeding with milk

  • This medicine passes into breast milk. It is therefore not recommended during breastfeeding regardless of the dose of aspirin to take.
  • Ask your doctor or pharmacist for advice before taking any medicine.

What happens if I overdose from Actron ?

Intoxication linked to aspirin and paracetamol is to be feared in the elderly and especially in young children (therapeutic overdose or frequent accidental poisoning), in whom it can be fatal.

Symptoms of an aspirin overdose:

  • Moderate intoxication: tinnitus, decreased sensation of hearing, headache, dizziness are the mark of an overdose and can be controlled by reducing the dosage.
  • Severe poisoning: Fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular collapse, respiratory failure, high blood sugar;
  • Symptoms of paracetamol overdose: nausea, vomiting, anorexia, pallor, abdominal pain usually appear within the first 24 hours.
  • Overdose, from 10 g of paracetamol in adults and 150 mg / kg body weight in a single dose in children, causes hepatic cytolysis likely to lead to a complete and irreversible necrosis, resulting in hepatocellular failure, metabolic acidosis, encephalopathy up to coma and death.
  • Simultaneously, an increase in hepatic transaminases were observed in lactico dehydrogenase, bilirubin and decreased prothrombin levels that may appear 12 to 48 hours after ingestion.

Emergency driving:

  • Immediate transfer to a specialized hospital environment;
  • Rapid evacuation of the product ingested by gastric lavage;
  • Before starting treatment:
    •  take a tube of blood to do the plasma dosage of paracetamol,
    • control of the acid-base balance;
  • Treatment of an aspirin overdose typically includes forced alkaline diuresis; hemodialysis or peritoneal dialysis is possible if necessary.
  • Treatment of paracetamol overdose conventionally comprises the administration as early as possible of the antidote N-acetylcysteine intravenously or orally if possible before the tenth hour.
  • Symptomatic treatment.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking Actron ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

Appearance and shape

  • Effervescent tablet
  • Effervescent tablets, packaged in 2, in heat-sealed film (paper / PE / aluminum / Surlyn). Box of 20 tablets.

Other shapes

  • ACTRON, effervescent tablet, box of 15 heat-sealed films of 2

Composition

Active ingredient Effervescent tablet

actron ingredients

Excipients with known effects ? : Presence of: Sodium

Other excipients:

  • Citric acid anhydrous.
  • Sodium bicarbonate,

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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Sedaspir tablet Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1869/sedaspir-tablet-uses-dosage-side-effects-precautions-warnings.html https://edrug-online.com/1869/sedaspir-tablet-uses-dosage-side-effects-precautions-warnings.html#respond Wed, 18 Nov 2020 10:35:14 +0000 https://edrug-online.com/?p=1869 SEDASPIR, tablet, box of 2 tubes of 10SEDASPIR, tablet, box of 2 tubes of 10 >> Generic drug of the therapeutic class: Analgesics active ingredients: Codeine , acetylsalicylic acid , caffeine Drug withdrawn from the market on 12/14/2018 what is Sedaspir medication used for and indication? Treatment in adults of pain of moderate to severe intensity and / or which is not […]]]> SEDASPIR, tablet, box of 2 tubes of 10

SEDASPIR, tablet, box of 2 tubes of 10 >> Generic drug of the therapeutic class: Analgesics
active ingredients: Codeine , acetylsalicylic acid , caffeine

Drug withdrawn from the market on 12/14/2018

what is Sedaspir medication used for and indication?

Treatment in adults of pain of moderate to severe intensity and / or which is not relieved by aspirin or paracetamol alone.

PRESENTATION (S) AVAILABLE FOR SEDASPIR

2 presentations are available for this medication:

  • 2 polypropylene tube (s) of 10 tablet (s)
  • polypropylene tube (s) of 20 tablet (s)
FEATURE DESCRIPTION
Pharmaceutical class not communicated
Active substance (s) for one tablet: acetylsalicylic acid (500.00 mg), caffeine monohydrate (50.00 mg), codeine (phosphate) hemihydrate (20.00 mg)
General medicine no
Pharmaceutical form compressed
Route (s) of administration oral
Selling price unregulated price
Social security reimbursement rate 0%
Laboratory (s) Laboratory (s) manufacturer Sedaspir
Conditions of issue available without prescription

Sedaspir Dosage

RESERVED FOR ADULTS.

1 tablet to be swallowed with a glass of water, to be renewed if necessary after 4 hours; possibly, 2 tablets in one take, in case of severe pain, without exceeding 6 tablets per day.

Sedaspir Contraindications

Never take SEDASPIR, tablet in the following cases:

  • From the 6th month of pregnancy
  • Child under 15 years old.
  • Known allergy to any of the constituents, aspirin or a related drug, especially nonsteroidal anti-inflammatory drugs.
  • Evolving stomach or duodenal ulcer.
  • Hemorrhagic disease or hemorrhagic risk.
  • Severe liver disease.
  • Respiratory failure.
  • Treatment with methotrexate (doses greater than or equal to 15 mg per week).
  • Treatment with oral anticoagulants when aspirin is prescribed at high doses (greater than or equal to 3 g per day).
  • Treatment with buprenorphine, nalbuphine or pentazocine
  • Feeding with milk.

This medicine SHOULD generally not be used UNLESS YOUR DOCTOR advises you to use:

  • enoxacin (antibiotic),
  • ticlopidine,
  • uricosurics (gout medications)
  • injectable heparins,
  • oral anticoagulants (for aspirin doses of less than 3 g per day)
  • other nonsteroidal anti-inflammatory drugs (for high doses of aspirin greater than or equal to 3 g per day).

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

How To Take Sedaspir ?

Administration mode

  • ORAL ROUTE.

Frequency of administration

  • The catches distributed throughout the day, prevent pain peaks. They should be spaced at least 4 hours apart.
  • Due to the presence of caffeine, avoid taking this medication at the end of the day.

Duration of the treatment

  • Do not use for a prolonged period without medical advice.

How To Store Sedaspir ?

Keep out of the reach and sight of children.

Expiration date

  • Do not use SEDASPIR, tablet after the expiry date stated on the box.

Storage conditions

  • Store at a temperature not exceeding 30 ° C.

If necessary, warnings against certain visible signs of deterioration

  • Medicines must not be disposed of via wastewater or household waste. Ask your pharmacist what to do with any unused medicine. These measures will help protect the environment.

Sedaspir Side Effects

Like all medicines, SEDASPIR, tablet can cause side effects, although not everybody gets them:

  • related to the presence of codeine: constipation, somnolence, dizziness, nausea, vomiting, respiratory discomfort, skin reactions.
  • related to the presence of aspirin: in some cases, it is possible that:
    • an allergic reaction such as a rash, angioedema (swelling and / or edema of the face) or an asthma attack
    • haemorrhage (discharge of blood through the mouth or in the stool, stool staining black). This is all the more frequent the higher the dosage used.
    • ringing in the ears, sensation of hearing loss, headaches: these usually indicate an overdose of aspirin.

Immediately stop taking this treatment and warn you

    • be a doctor.
  • linked to the presence of caffeine: possibility of excitement, insomnia, palpitations.

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Sedaspir Interactions

IN ORDER TO AVOID POSSIBLE INTERACTIONS BETWEEN SEVERAL MEDICINES, especially with buprenorphine, nalbuphine or pentazocine, methotrexate, oral anticoagulants, other non-steroidal anti-inflammatory drugs, certain anticoagulants, uricosurics (gout drugs), enoxacin, alcohol and drugs containing alcohol, ANY OTHER CURRENT TREATMENT SHOULD SYSTEMATICALLY REPORT TO YOUR DOCTOR OR YOUR PHARMACIST.

This medicine contains aspirin, codeine and. caffeine. Other medicines contain it. Do not combine them so as not to exceed the maximum recommended doses

Effects on ability to Drive and use machines

  • The attention of machine users and vehicle drivers is drawn to the risks of drowsiness associated with the use of this medication.
  • This phenomenon is accentuated by the consumption of alcoholic beverages.

Warnings and Precautions

Special warnings

  • Do not use this medication for a long time because of the risk of dependence.
  • In the event of a chronic (long-term) disease of the bronchi or lungs accompanied by sputum, in the event of liver disease or digestive history (hemorrhage, old ulcer), heavy periods or contraception by IUD, or kidney disease as well as in the elderly. A MEDICAL ADVICE IS ESSENTIAL.

Precautions for use

  • The intake of alcoholic beverages during this treatment is not recommended.

IN CASE OF DOUBT, DO NOT HESITATE TO ASK FOR THE ADVICE OF YOUR DOCTOR OR YOUR PHARMACIST.

Pregnancy and breast feeding

  • This medicine will only be used during the first 5 months of pregnancy on the advice of your doctor.
  • This medication is contraindicated from the 6th month of pregnancy.
  • This drug passes into breast milk, therefore breast-feeding is contraindicated during treatment.
  • If you discover that you are pregnant during treatment, consult your doctor as only he can judge the need for continued treatment.
  • Ask your doctor or pharmacist for advice before taking any medicine.

What happens if I overdose from Sedaspir ?

ASPIRIN OVERDOSAGE :

  • Aspirin-related poisoning is to be feared in the elderly and especially in young children (therapeutic overdose or frequent accidental poisoning), in whom it can be fatal.

Clinical symptoms :

  • Moderate poisoning: Ringing in the ears, feeling of hearing loss, headache, dizziness are signs of overdose and can be controlled by reducing the dosage.
  • Severe poisoning: fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular collapse, respiratory failure, severe hypoglycemia.

Treatment :

  • Immediate transfer to a specialized hospital environment.
  • Rapid evacuation of the product ingested by gastric lavage.
  • Control of acid-base balance.
  • Forced alkaline diuresis, possibility of hemodialysis or peritoneal dialysis, if necessary.
  • Symptomatic treatment.

CODEINE OVERDOSAGE :

  • Symptoms in adults : acute depression of the respiratory centers (cyanosis, bradypnea), somnolence, rash, vomiting, pruritus, ataxia, pulmonary edema (rarer).
  • Symptoms in children(toxic threshold: 2 mg / kg as a single dose): bradypnea, respiratory pauses, miosis, convulsions, signs of histaminoliberation: facial flushing and edema, urticarial rash, collapse, urine retention.

What to do :

  • Assisted stimulation-ventilation before cardiopulmonary resuscitation in a specialized department.
  • Specific treatment with naloxone: establishment of an approach with monitoring for the time necessary for the symptoms to disappear.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking Sedaspir ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

Appearance and shape

  • White round tablet debossed with “S” on one side.
  • Box of 2 polypropylene tubes of 10 tablets, closed with a low density polyethylene cap containing a desiccant (silica gel).

Composition

What does SEDASPIR contain, tablet?

The active substances are:

  • Acetylsalicylic acid …….. 500.00 mg
  • Caffeine monohydrate ………. 50.00 mg
  • Either in anhydrous caffeine …….. 45.80 mg
  • Codeine phosphate hemihydrate ……….. 20.00 mg

For a tablet.

The other ingredients are:

  • Starch (STARCH 1500), silica (Aerosil 300), glycerol monostearate, talc.

Pharmaceutical form and content

What is SEDASPIR, tablet and contents of the pack?

This medication is in the form of tablets. Box of 1 tube of 20 or 2 tubes of 10.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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Dolidon Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1916/dolidon.html https://edrug-online.com/1916/dolidon.html#respond Wed, 18 Nov 2020 10:34:44 +0000 https://edrug-online.com/?p=1916 DOLIDON 500 mg / 50 mg, film-coated tablet, box of 16Generic drug of the Therapeutic class: Analgesics active ingredients: Paracetamol , Caffeine Medicinal product withdrawn from the market on 08/18/2009 what is Dolidon ? This drug is a specialty of SELF-MEDICATION it is intended for adults and children over 15 years old the absence of rapid recovery requires medical advice IF IN DOUBT, NEVER HESITATE […]]]> DOLIDON 500 mg / 50 mg, film-coated tablet, box of 16

Generic drug of the Therapeutic class: Analgesics
active ingredients: Paracetamol , Caffeine

Medicinal product withdrawn from the market on 08/18/2009

what is Dolidon ?

  • This drug is a specialty of SELF-MEDICATION
    • it is intended for adults and children over 15 years old
    • the absence of rapid recovery requires medical advice
  • IF IN DOUBT, NEVER HESITATE TO CALL YOUR DOCTOR, YOUR PHARMACIST.

what is Dolidon medication used for and indication?

This medicine contains paracetamol and caffeine; it is an analgesic (it calms the pain) and an antipyretic (it lowers the fever).

It is recommended for short-term treatment:

  • pain, such as: headache, toothache, painful periods, pain due to mild trauma (contusion, etc.)
  • feverish and “flu” states.

PRESENTATION (S) AVAILABLE FOR DOLIDON 500 MG / 50 MG

2 presentations are available for this medication:

  • 1 amber glass vial (s) of 16 tablet (s)
  • PVC-Aluminum blister pack (s) of 16 tablet (s)
FEATURE DESCRIPTION
Pharmaceutical class not communicated
Active substance (s) for one tablet: caffeine (50.00 mg), paracetamol (500.00 mg)
General medicine no
Pharmaceutical form coated tablet
Route (s) of administration oral
Selling price unregulated price
Social security reimbursement rate 0%
Laboratory (s) Laboratory (s) manufacturer Dolidon 500 mg / 50 mg
Conditions of issue available without prescription

Dolidon Dosage

  • ADULTS AND CHILDREN OVER 15 YEARS OLD.
  • Take 1 to 2 tablets per dose, 1 to 3 times a day.
  • Do not exceed the maximum dosage of 6 tablets per day.
  • Swallow the tablets with a full glass of water.
  • The catches must be spaced at least 4 hours apart.
  • Avoid taking at the end of the afternoon.

Dolidon Contraindications

Do not take DOLIDON 500 mg / 50 mg film-coated tablets in the following cases:

  • Previous allergies to paracetamol and or to one of the components of the product.
  • Severe liver disease.
  • Children under 15.

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK YOUR DOCTOR OR YOUR PHARMACIST FOR THE ADVICE.

How To Take Dolidon ?

Administration mode

  • ORAL

Duration of the treatment

  • The usual duration of treatment is less than 5 days: 3 days maximum, in case of fever
  • 5 days maximum, in case of pain.

how does Dolidon work?

  • Paracetamol : Analgesic and antipyretic.
  • Caffeine : Central stimulant which only potentiates the analgesic effect of paracetamol.

How To Store Dolidon ?

Keep out of the reach and sight of children.

Expiration date

  • Do not use DOLIDON 500 mg / 50 mg film-coated tablet after the expiry date stated on the box.

Storage conditions

  • No special storage conditions.
  • If necessary, warnings against certain visible signs of deterioration

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist what to do with any unused medicine. These measures will help protect the environment.

Dolidon Side Effects

Like all medicines, DOLIDON 500 mg / 50 mg film-coated tablets can cause side effects, although not everybody gets them:

  • Excitement, insomnia, palpitations.
  • Possibility:
    • hives, redness, rash (signs of an allergic reaction),
    • nausea, vomiting, lack of appetite, pallor, stomach pain (most often the sign of an overdose),

IN SUCH CASES :

  • STOP TREATMENT IMMEDIATELY AND TELL YOUR DOCTOR.
  • DO NOT HESITATE TO ASK FOR THE ADVICE OF YOUR DOCTOR OR YOUR PHARMACIST.
  • If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.
  • Keep out of the reach and sight of children.

Dolidon Interactions

RELATED TO PARACETAMOL

INTERACTIONS WITH PARACLINIC TESTS :

  • Taking paracetamol can distort the dosage of uric acid in the blood by the phosphotungstic acid method, and the dosage of blood sugar by the glucose oxidase-peroxidase method.

RELATED TO CAFEINE : ADVISED

ASSOCIATION WITH IDROCILAMIDE :

  • Significant increase in caffeine levels in the body, which can lead to excitement and hallucination by reducing the hepatic catabolism of caffeine.

Effects on ability to Drive and use machines

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Warnings and Precautions

Special warnings

WARNING

  • many medicines may contain paracetamol and / or caffeine. Do not combine them so as not to exceed the maximum recommended doses.

Precautions for use

  • In case of kidney disease, seek the advice of your doctor.
  • If the pain persists for more than 5 days or the fever for more than 3 days, if they worsen or if any other sign occurs, do not continue treatment without the advice of your doctor or pharmacist.

CONSULT YOUR DOCTOR

  • In the event of overdose or accidental poisoning, TELL YOUR DOCTOR IMMEDIATELY.
  • Do not associate with the intake of alcoholic drinks.
  • This medicine contains an azo agent: cochineal red A (E151) and may cause allergic reactions.

IN CASE OF DOUBT, DO NOT HESITATE TO ASK FOR THE ADVICE OF YOUR DOCTOR OR YOUR PHARMACIST.

NEVER LEAVE WITHIN THE REACH OF CHILDREN.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • In animals: There is no study of teratogenesis.
  • In women:
    • First trimester: A prospective epidemiological study involving a few hundred women did not reveal any teratogenic effect.
    • No fetal toxicity to date has been described during administration during the second and third trimesters of pregnancy.
    • Consequently, paracetamol, under normal conditions of use, can be prescribed during pregnancy.

Breast-feeding

  • At therapeutic dose, administration of this drug is possible during breast-feeding.

What happens if I overdose from Dolidon ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking Dolidon ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

Appearance and shape

  • Dark pink round film-coated tablet.
  • 16 tablets in blister packs (PVC / Aluminum).

Composition

Active ingredient Coated tablet

* per unit dose

Active ingredients: Paracetamol , Caffeine

Excipients: Bare tablet: Microcrystalline cellulose (Avicel pH 102) , Colloidal anhydrous silica (AEROSIL 200) , Acid stearic , Magnesium stearate , Film-coated tablet: Hypromellose , Microcrystalline cellulose , Macrogol stearate 40 , Titanium dioxide , Cochineal Carmine , Macrogol 600

No excipient with known effect ? is not present in the composition of this drug

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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Migralgine capsule Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1924/migralgine.html https://edrug-online.com/1924/migralgine.html#respond Wed, 18 Nov 2020 10:34:33 +0000 https://edrug-online.com/?p=1924 MigralgineGeneric drug of the therapeutic class: Analgesicsactive ingredients: Paracetamol , Codeine , Caffeine what is Migralgine medication used for and indication? Treatment in adults of painful conditions of moderate to intense intensity and / or which are not relieved by paracetamol or aspirin alone. PRESENTATION (S) AVAILABLE FOR MIGRALGINE 2 presentations are available for this medication: 2 blister […]]]> Migralgine

Generic drug of the therapeutic class: Analgesics
active ingredients: ParacetamolCodeineCaffeine

what is Migralgine medication used for and indication?

Treatment in adults of painful conditions of moderate to intense intensity and / or which are not relieved by paracetamol or aspirin alone.

PRESENTATION (S) AVAILABLE FOR MIGRALGINE

2 presentations are available for this medication:

  • 2 blister (s) PVC aluminum of 6 capsule (s)
  • 3 PVC aluminum blister (s) of 6 capsule (s)

FEATURE

DESCRIPTION

Pharmaceutical class

not communicated

Active substance (s)

for one capsule: caffeine (62.5 mg), paracetamol (400.0 mg), codeine (phosphate) hemihydrate (20.0 mg)

General medicine

no

Pharmaceutical form

capsule

Route (s) of administration

oral

Selling price

unregulated price

Social security reimbursement rate

0%

Laboratory (s)

Migralgine manufacturer (s)

Conditions of issue

available without prescription

Migralgine Dosage

RESERVED FOR ADULTS.

The recommended daily dose of paracetamol is approximately 60 mg / kg / day, divided into 4 or 6 divided doses, i.e. approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours.

1 capsule, to be renewed if necessary after 4 hours, or possibly 2 capsules per dose in the event of severe pain, without exceeding 6 capsules per day.

However, in case of more intense pain, and on the advice of your doctor, the total dose may be increased up to 4 g per day.

However:

  • doses greater than 3 g of paracetamol per day require medical advice.
  • NEVER TAKE MORE THAN 4 GRAMS OF PARACETAMOL PER DAY (taking into account all drugs containing paracetamol in their formula).

Always respect an interval of at least 4 hours between the catches.

In the event of severe kidney disease (severe renal failure), the intakes should be 8 hours apart and the total dose should not exceed 6 capsules per day (3 g).

IF IN DOUBT, ASK YOUR DOCTOR OR PHARMACIST FOR ADVICE.

Migralgine Contraindications

Never take MIGRALGINE, capsule in the following cases:

  • Child under 15 years old.
  • Allergy to paracetamol and / or codeine, or to other constituents.
  • Severe liver disease.
  • Respiratory failure regardless of its importance.
  • Feeding with milk.

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

How To Take Migralgine ?

Administration mode

  • Oral route.
  • The capsules are to be swallowed without opening them with a drink (eg water, milk, fruit juice).

Frequency of administration

  • Systematic catches prevent oscillations of pain or fever.
  • In adults, they must be spaced at least 4 hours apart.
  • In the event of serious kidney disease (severe renal failure), the catches should be spaced at least 8 hours apart.

Duration of the treatment

  • Do not use for a prolonged period without medical advice.

How To Store Migralgine ?

Keep this medication out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton. The expiration date refers to the last day of that month .

Store at a temperature not exceeding 30 ° C and protected from moisture.

Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

Migralgine Side Effects

Like all medicines, MIGRALGINE, capsule can cause side effects, although not everybody gets them.

RELATED TO THE PRESENCE OF PARACETAMOL

  • In rare cases, a rash or redness of the skin or an allergic reaction may occur, which may manifest as sudden swelling of the face and neck or sudden discomfort with a drop in blood pressure. You must stop treatment immediately , tell your doctor and never take medicines containing paracetamol again.
  • Exceptionally, biological changes requiring control of the blood test have been observed: abnormally low levels of certain white blood cells or certain blood cells such as platelets which may result in nosebleeds or gums. In this case, consult a doctor.

RELATED TO THE PRESENCE OF CODEINE

Possibility of :

  • feeling drowsy, euphoria, mood swings,
  • narrowing of the pupil, difficulty urinating,
  • constipation, nausea, vomiting,
  • drowsiness, dizziness,
  • hypersensitivity reactions (pruritus, hives and, in rare cases, extensive rash),
  • respiratory problems,
  • abdominal pain especially in cholecystectomized patients (without gallbladder).

RELATED TO THE PRESENCE OF CAFEINE

This medicine may cause you to feel excited, sleepless, and heart beat.

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Migralgine Interactions

This drug should be avoided with morphine agonist-antagonists (buprenorphine, nalbuphine, pentazocine), with alcoholic beverages or drugs containing alcohol, with naltrexone or with enoxacin (antibiotic).

Report that you are taking this medicine if your doctor prescribes a test for the level of uric acid in the blood.

If you are taking or have recently taken any other medicines, including medicines obtained without a prescription, talk to your doctor or pharmacist.

Effects on ability to Drive and use machines

  • The attention of machine users and vehicle drivers is drawn to the risks of drowsiness associated with the use of this medication.
  • This phenomenon diminishes after several takes.
  • This phenomenon is accentuated by the consumption of alcoholic beverages.

Warnings and Precautions

Special warnings

Please note, this medication is not a treatment for migraine or headache.

  • This medicine contains paracetamol. In case of overdose or mistakenly taking too high a dose, consult your doctor immediately.
  • Depending on your individual ability to process codeine, you may show signs of overdose even if you are taking this medicine at the dose recommended by your doctor. If symptoms such as dizziness, drowsiness, abdominal pain, and difficulty breathing appear, tell your doctor immediately.
  • This medicine contains paracetamol, codeine and caffeine. Other medicines contain it. Do not combine them so as not to exceed the maximum recommended doses.
  • Do not use this medication for a long time because of the risk of dependence.
  • Some pain may not be relieved by this medicine, ask your doctor for advice.
  • This medicine contains lactose. Its use is not recommended in patients with lactose intolerance (a rare hereditary disease).

Precautions for use

  • If the pain persists for more than 5 days or the fever for more than 3 days, or in the event of insufficient efficacy or the occurrence of any other sign, do not continue treatment without the advice of your doctor.
  • Before taking this medicine, it is necessary to consult your doctor in case of severe kidney or liver disease.
  • Due to the presence of caffeine, this medication can cause insomnia; consequently, catches at the end of the day should be avoided.
  • This medication is not recommended with morphine agonist-antagonists (buprenorphine, nalbuphine, pentazocine), the intake of alcoholic beverages or drugs containing alcohol, naltrexone or enoxacin (antibiotic).
  • IF IN DOUBT, DO NOT HESITATE TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • This medicine will only be used during pregnancy on the advice of your doctor.
  • If you discover that you are pregnant during treatment, consult your doctor as only he can judge the need for continued treatment.

Feeding with milk

  • This medicine passes into breast milk.
  • Never take this medicine without medical advice if you are breast-feeding. This is because you could expose your baby to serious side effects.
  • Any manifestation of undesirable effect in you (very strong drowsiness, confusion or respiratory depression) or in your child (drowsiness, difficulty in sucking, breathing difficulties) requires prompt stopping your treatment with codeine and consultation with your doctor.
  • In the event of breast-feeding, apart from a one-off intake on prescription from your doctor, this medication is contraindicated.
  • In general, during pregnancy or breastfeeding, always seek the advice of your doctor or pharmacist before using any medication.

What happens if I overdose from Migralgine ?

Immediately consult your doctor or pharmacist.

What should I do if I miss a dose?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What happens if you stop taking Migralgine ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

What is  Forms and Composition ?

COMPOSITION

Active substances

  • Paracetamol: 400.0 mg
  • Caffeine: 62.5 mg
  • Codeine phosphate hemihydrate: 20.0 mg
  • For a capsule.

Other components

  • Colloidal anhydrous silica, lactose monohydrate, glycerol monostearate.
  • Composition of the capsule shell: gelatin, indigotine (E 132), quinoline yellow (E 104), titanium dioxide (E 171).

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

]]>
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temgesic 0.2 mg sublingual tablet Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1841/temgesic-tablet.html https://edrug-online.com/1841/temgesic-tablet.html#respond Tue, 10 Nov 2020 11:38:38 +0000 https://edrug-online.com/?p=1841 temgesic sublingual tabletstemgesic 0.2 mg sublingual tablet  >> Generic drug of the Therapeutic class: Analgesics active ingredients: Buprenorphine what is temgesic 0.2 mg sublingual tablet ? This medication is an analgesic (it relieves pain). what is temgesic medication used for and indication? This medication is recommended for severe pain, in particular that which is resistant to other analgesic drugs […]]]> temgesic sublingual tablets

temgesic 0.2 mg sublingual tablet  >> Generic drug of the Therapeutic class: Analgesics
active ingredients: Buprenorphine

what is temgesic 0.2 mg sublingual tablet ?

This medication is an analgesic (it relieves pain).

what is temgesic medication used for and indication?

This medication is recommended for severe pain, in particular that which is resistant to other analgesic drugs (for example following certain surgical procedures).

PRESENTATION (S) AVAILABLE FOR TEMGESIC 0.2 MG

8 presentations are available for this drug:

  • High density polyethylene (HDPE) bottle (s) of 20 tablet (s)
  • High density polyethylene (HDPE) bottle (s) of 30 tablet (s)
  • High density polyethylene (HDPE) bottle (s) of 50 tablet (s)
  • High density polyethylene (HDPE) bottle (s) of 100 tablet (s)
  • nylon aluminum uPVC blister pack (s) of 20 tablet (s)
  • nylon aluminum uPVC blister pack (s) of 30 tablet (s)
  • nylon aluminum uPVC blister pack (s) of 50 tablet (s)
  • nylon aluminum uPVC blister pack (s) of 100 tablet (s)
FEATURE DESCRIPTION
Pharmaceutical class pain relievers
Active substance (s) for one tablet: buprenorphine (hydrochloride) (0.216 mg)
General medicine no
Pharmaceutical form compressed
Route (s) of administration sublingual
Social security reimbursement rate 65%
Laboratory (s) RB PHARMACEUTICALS FRANCE
Conditions of issue available by simple prescription

temgesic Dosage

  • The dosage should be adjusted according to the intensity of the pain.
  • In adults: 1 to 2 tablets per dose, on average 3 times per day.
  • In subjects over 65 years of age and in particular over 80 years: the dosage should be reduced by half.
  • For older children aged 7 to 15: 1 to 2 tablets per 24 hours, depending on weight, under careful medical supervision.
  • STRICTLY COMPLY WITH THE MEDICAL PRESCRIPTION.

temgesic Contraindications

Never use TEMGESIC 0.2 mg sublingual tablet in the following cases:

  • known allergy to buprenorphine or to any of the ingredients of this medication,
  • children under 7,
  • severe respiratory failure,
  • severe liver disease,
  • acute alcohol poisoning and alcohol withdrawal syndrome (delirium tremens),
  • treatment with other morphine analgesics.

IN CASE OF DOUBT, IT IS ESSENTIAL TO ASK FOR THE OPINION OF YOUR DOCTOR OR YOUR PHARMACIST.

How do you take Temgesic?

Method and route of administration

  • Sublingual route.
  • The tablets should not be swallowed or chewed: place them under the tongue and allow them to dissolve slowly.

Frequency of administration

  • STRICTLY COMPLY WITH THE MEDICAL PRESCRIPTION.

Duration of treatment

  • STRICTLY COMPLY WITH THE MEDICAL PRESCRIPTION.

how does temgesic work?

  • After sublingual administration of 0.4 mg of buprenorphine, the drug is dosed in plasma from the 30 th minute and the peak plasma concentration is reached within 2 to 3 hours.
  • The absolute bioavailability is of the order of 75%.
  • The biotransformation of buprenorphine takes place in the liver where it undergoes N-dealkylation and glucuronoconjugation.
  • Excretion of buprenorphine occurs primarily in the bile and stool.

How To Store temgesic ?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the carton and blister, EXP. The expiration date refers to the last day of that month.
  • Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

temgesic Side Effects

Like all medicines, TEMGESIC 0.2 mg sublingual tablets can cause side effects, although not everybody gets them.

The following side effects have been observed:

  • Common side effects (1% -10%): constipation, nausea, vomiting, insomnia, headache, malaise and dizziness, fatigue, drowsiness, drop in blood pressure when changing from lying or sitting to lying down or sitting down standing, sweating.
  • Rare side effects (0.01% -0.1%): respiratory failure, hallucinations, hepatitis (liver damage) with jaundice.
  • Other reported side effects: hypersensitivity reactions (allergy), such as rash, pruritus (itching), bronchospasm (bronchial spasm), angioedema (swelling of the face and neck which may cause breathing difficulties) and anaphylactic shock ( severe generalized allergic reaction).

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

temgesic Interactions

Contraindicated associations

Level III morphine agonists ( alfentanil, dextromoramide, fentanyl, hydromorphone, morphine, oxycodone, pethidine, phenoperidine, remifentanyl, sufentanil )

  • Decrease in the analgesic effect by competitive blocking of receptors, with the risk of the appearance of a withdrawal syndrome.

Not recommended associations

Other morphine analgesics

  • Decrease in the analgesic effect by blocking the receptors with the risk of the appearance of a withdrawal syndrome.

Alcohol

  • Alcohol enhancement of the sedative effect of buprenorphine; impaired alertness can make driving and using machines dangerous.
  • Avoid taking alcoholic drinks and drugs containing alcohol.

Associations to take into account

Benzodiazepines

  • Increased risk of respiratory depression, which may be fatal in case of overdose.

Other sedative drugs:

morphine derivatives (analgesics, cough suppressants and substitution treatments), neuroleptics, barbiturates, benzodiazepines, anxiolytics other than benzodiazepines (eg meprobamate), hypnotics, sedative antidepressants (amitriptyline, doxepine, mirtiprazine, mirtazamine, ), sedative H 1 antihistamines , central antihypertensive drugs, baclofen and thalidomide:

Increase in central depression. Impaired vigilance can make driving and using machines dangerous.

Combinations subject to precautions for use

CYP3A4 inhibitors ( amprenavir and by extrapolation fosamprenavir, alazanavir, itraconazole, ketoconazole, nelfinavir, ritonavir )

  • Increase in buprenorphine concentrations due to a decrease in its hepatic metabolism, with the risk of an increase in its adverse effects. Clinical monitoring and dosage adjustment of buprenorphine during treatment with the protease inhibitor and, if necessary, after its discontinuation.

Effects on ability to Drive and use machines

Attention is drawn, especially among vehicle drivers and users of machines, to the risk of drowsiness associated with the use of this medication.

Warnings and Precautions

Special warnings

  • This medicine can cause psychological and physical dependence during prolonged treatment.
  • This drug can cause drowsiness which may be increased by products such as alcoholic drinks, tranquilizers, sedative drugs, sleeping pills.
  • This medicine contains lactose. Its use is not recommended in patients with lactose intolerance (a rare hereditary disease).

Precautions for use

  • In case of surgery, tell the anesthesiologist to take this medication.
  • IN CASE OF DOUBT, DO NOT HESITATE TO ASK FOR THE ADVICE OF YOUR DOCTOR OR YOUR PHARMACIST.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • Clinically, there is currently no sufficiently relevant data to assess a possible malformative or fetotoxic effect of buprenorphine when it is administered during pregnancy.
  • However, given the expected benefit to the mother, buprenorphine may be prescribed during pregnancy.
  • During the last three months of pregnancy, chronic use of buprenorphine by the mother, regardless of the dose, can cause withdrawal syndrome in the newborn.
  • In addition, at the end of pregnancy, high doses of buprenorphine, even in brief treatment, are liable to cause respiratory depression in the newborn.
  • Consequently, at the end of pregnancy in the event of occasional high doses or chronic administration of buprenorphine, neonatal monitoring should be considered because of a theoretical risk of respiratory depression or withdrawal syndrome in the newborn. .

Feeding with milk

  • Due to the passage of buprenorphine and its metabolites in breast milk and insufficient clinical data, it is preferable as a precaution to avoid breast-feeding in case of maternal treatment.

What happens if I overdose from temgesic ?

  • Despite a large safety margin, overdose can occur with high dosages.
  • In the event of accidental overdose, comprehensive management should be instituted, including close monitoring of the patient’s respiratory and cardiac status. The main symptom to be treated is respiratory depression, which can lead to respiratory arrest and death. If the patient vomits, precautions should be taken to avoid bronchial inhalation of digestive contents.

Treatment :

  • Symptomatic treatment of respiratory depression by appropriate means should be initiated. Freedom of the upper airways should be ensured as well as controlled ventilation, or assisted if necessary. The use of an opioid antagonist (naloxone) is recommended, despite its modest effect on the respiratory symptoms due to buprenorphine, the latter being strongly bound to the morphine receptors. Doxapram can also be used.
  • Postoperatively, one of the components of respiratory depression may be the residual effect of previously administered narcotics, so naloxone should be given as a first-line treatment, then the use of doxapram may be considered.
  • In the event of administration of an opioid antagonist (naloxone), the long duration of action of the product should be taken into account.

What should I do if I miss a dose?

  • Ask the prescribing doctor for his opinion.

What happens if you stop taking temgesic ?

  • Abrupt discontinuation of treatment may lead to the appearance of a withdrawal syndrome.
  • If you have further questions on the use of this medicine, ask your doctor or pharmacist for more information.

What is  Forms and Composition ?

Appearance and shape

  • White tablet.
  • 20 tablets in blister packs (Nylon / Aluminum / uPVC).

Other shapes

Composition

Active ingredient Sublingual tablet

Buprenorphine 0.2 mg * * per unit dose

Active ingredients: Buprenorphine

Excipients with known effects ? : Lactose

Other excipients:

Mannitol, Corn starch, Polyvidone excipient, Citric acid, Magnesium stearate, Sodium citrate

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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soluvit Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1783/soluvit.html https://edrug-online.com/1783/soluvit.html#respond Thu, 05 Nov 2020 09:57:46 +0000 https://edrug-online.com/?p=1783 SOLUVIT, lyophilisate for parenteral use, box of 10 vials (glass) of 1SOLUVIT, lyophilisate for parenteral use, box of 10 vials (glass) of 1  >>> Generic Medication Therapeutic Class: Anesthesia, resuscitation, analgesic active ingredients: Thiamine , Riboflavin (E101) , nicotinamide , pyridoxine , sodium pantothenate , sodium ascorbate (E301) , Biotin , Folic Acid , Cyanocobalamin what is soluvit ? It is a water-soluble vitamin supplementation what is soluvit medication used for and indication? Supplementation with water-soluble vitamins to cover the daily needs of adults […]]]> SOLUVIT, lyophilisate for parenteral use, box of 10 vials (glass) of 1

SOLUVIT, lyophilisate for parenteral use, box of 10 vials (glass) of 1  >>> Generic Medication Therapeutic Class: Anesthesia, resuscitation, analgesic
active ingredients: Thiamine , Riboflavin (E101) , nicotinamide , pyridoxine , sodium pantothenate , sodium ascorbate (E301) , Biotin Folic Acid , Cyanocobalamin

what is soluvit ?

It is a water-soluble vitamin supplementation

what is soluvit medication used for and indication?

Supplementation with water-soluble vitamins to cover the daily needs of adults and children in parenteral nutrition.

PRESENTATION (S) AVAILABLE FOR SOLUVIT

2 presentations are available for this medication:

  • 1 glass bottle (s)
  • 10 glass bottle (s)
FEATURE DESCRIPTION
Pharmaceutical class blood derivatives and various infusions
Active substance (s) for a lyophilisate: biotin (0.060 mg), riboflavin (sodium phosphate) dihydrate (4.9 mg), folic (acid) (0.4 mg), sodium (ascorbate) (113 mg), cyanocobalamin (0.005 mg) , nicotinamide (40 mg), pyridoxine (hydrochloride) (4.9 mg), thiamine mononitrate (3.1 mg), pantothenate-sodium (16.5 mg)
General medicine no
Pharmaceutical form lyophilisate for parenteral use
Route (s) of administration intravenous
Social security reimbursement rate 65%
Laboratory (s) FRESENIUS KABI FRANCE
Conditions of issue restricted prescription drug

soluvit Dosage

  • In adults and children weighing 10 kg and over, the recommended dosage corresponds to the vitamin intake from one reconstituted vial per 24 hours.
  • In children weighing less than 10 kg, the recommended dosage corresponds to the vitamin intake of one milliliter from a reconstituted vial per kilogram of weight and per 24 hours.

COMPLY WITH THE MEDICAL ADVICE

soluvit Contraindications

Never use SOLUVIT, lyophilisate for parenteral use in the following situations:

  • in the event of known hypersensitivity to any of the components, in particular do not inject into subjects who have shown signs of intolerance to thiamine (vitamin B1) and to methyl parahydroxybenzoate;
  • in combination with drugs based on levodopa.

How To Take soluvit ?

Method and route of administration

  • Strict intravenous use.
  • SOLUVIT, lyophilisate for parenteral use must be reconstituted before use.
  • Reconstitution is accomplished by the addition, under aseptic conditions, of an injectable lipid solution or emulsion for intravenous infusion.
  • The reconstituted lyophilisate should never be injected directly into the vein, but should always be added to a solution or an emulsion for intravenous infusion, the compatibility of which with the reconstituted lyophilisate SOLUVIT has been determined beforehand.

COMPLY WITH THE MEDICAL ADVICE

Frequency of administration

COMPLY WITH THE MEDICAL ADVICE

Duration of the treatment

COMPLY WITH THE MEDICAL ADVICE

how does soluvit work?

Pharmacotherapeutic group: ADDITIVES FOR INTRAVENOUS SOLUTIONS / VITAMINS, ATC code: B05XC

(B: Blood and hematopoietic organs)

SOLUVIT is a balanced combination of water-soluble vitamins covering the daily needs during parenteral nutrition. SOLUVIT does not contain fat-soluble vitamins, which are nevertheless essential in the case of exclusive parenteral nutrition.

The pharmacodynamic properties of SOLUVIT are those of each of the 9 water-soluble vitamins included in its composition. The main properties are as follows:

  • Vitamin B1 (thiamine): in association with ATP, formation of a coenzyme involved in the metabolism of carbohydrates.
  • Vitamin B2 (riboflavin): coenzyme action in cellular energy metabolism, tissue respiration systems and macro-nutrient metabolism.
  • Vitamin B3 (PP): component of NAD and NADP coenzymes involved in oxidation-reduction reactions essential for the metabolism of macro-nutrients and tissue respiration.
  • Vitamin B5 (pantothenic acid): precursor of coenzyme A involved in the oxidative metabolism of carbohydrates, gluconeogenesis and synthesis of fatty acids, sterols, steroid hormones and porphyrins.
  • Vitamin B6 (pyridoxine): coenzyme in the metabolism of proteins, carbohydrates and fats.
  • Vitamin B12: exogenous source necessary for the synthesis of nucleoproteins and myelin, cell reproduction, growth and maintenance of normal erythropoiesis.
  • Vitamin C: antioxidant properties, essential for the formation and maintenance of intercellular substance and collagen biosynthesis of catecholamines, the synthesis of carnitine and steroids, metabolism of folic acid and tyrosine.
  • Folic acid: exogenous source necessary for the synthesis of nucleoproteins and the maintenance of normal erythropoiesis.
  • Biotin: linked to at least four enzymes, is involved in energy metabolism including gluconeogenesis.

How To Store soluvit ?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the vial after EXP. The expiration date refers to the last day of that month.
  • Store at a temperature not exceeding + 25 ° C and store the vial in the outer carton, in order to protect from light.
  • Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

soluvit Side Effects

Like all medicines, SOLUVIT, lyophilisate for parenteral use can cause side effects, although not everybody gets them.

  • Taking into account the presence of vitamin B1 (thiamine), it is possible to observe anaphylactic reactions in subjects presenting an allergic ground.
  • If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.
  • Keep out of the reach and sight of children.

soluvit Interactions

Combinations subject to precautions for use

(Related to the presence of sodium ascorbate)

DEFEROXAMINE

  • Increased risk of iron-induced heart failure due to increased iron mobilization by supraphysiological vitamin C supplementation.
  • In case of hemochromatosis, give vitamin C only after starting treatment with deferoxamine. Monitor cardiac function in combination. For specific precautions, refer to the Summary of Product Characteristics for deferoxamine.

(Related to the presence of folic acid)

PHENOBARBITAL, PHENYTOIN, PRIMIDONE, FOSPHENYTOIN

  • Decrease in plasma concentrations of enzyme-inducing anticonvulsants by increasing their hepatic metabolism, folate of which is one of the cofactors in the enzymatic reactions concerned, which increases the risk of convulsions.
  • Clinical monitoring, monitoring of plasma levels of phenobarbital, phenytoin, primidone or fosphenytoin. Adjustment, if necessary, of the antiepileptic dosage during folic supplementation and after its discontinuation.

Associations to take into account

(Related to the presence of pyridoxine)

ETHIONAMIDE

PYRIDOXINE ANTAGONISTS (including cycloserine, hydralazine, isoniazid, penicillamine, phenelzine)

  • May cause pyridoxine deficiency.

(Related to the presence of folic acid)

FLUOROPYRIMIDINES (5-fluorouracil, capecitabine, tegafur)

  • Increased cytotoxicity of fluoropyrimidines when combined with folic acid.

FOLATE ANTAGONISTS (e.g., methotrexate, sulfasalazine, pyrimethamine, triamterene, trimethoprim) AND HIGH DOSES OF TEA CATECHINS:

  • Blocking the conversion of folate to their active metabolites and reducing the effectiveness of supplementation.

Interactions with other vitamin and / or mineral supplements

  • Some drugs can interact with certain vitamins and / or minerals at doses significantly higher than those provided by SOLUVIT, lyophilisate for parenteral use. This should be taken into account in patients receiving vitamins and / or minerals from more than one source; where appropriate, patients should be monitored for these interactions and managed appropriately.

Other forms of interactions

  • Depending on the reagents used, the presence of ascorbic acid in blood and urine may interfere with the results of some blood and urine glucose monitoring systems, including test strips and portable glucose monitors . precautions for use).
  • This medicinal product must not be mixed with other medicinal products except those mentioned in the section Posology and method of administration.

Effects on ability to Drive and use machines

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

Warnings and Precautions

  • SOLUVIT, lyophilisate for parenteral use, does not contain any fat-soluble vitamin which is nevertheless essential in the event of exclusive parenteral nutrition.
  • SOLUVIT, containing folic acid, may delay the diagnosis of Biermer’s anemia.
  • SOLUVIT, lyophilisate for parenteral use must be reconstituted before use.
  • The reconstituted product must not be injected directly into the vein but always added to a solution or an emulsion for infusion compatible with SOLUVIT: see.
  • Check before use that the bottle is free from cracks or splinters.
  • Do not keep a partially used vial.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • Studies in animals have not shown any teratogenic effect of the vitamins that make up SOLUVIT. In the absence of a teratogenic effect in animals, a malformative effect in humans is not expected. Indeed, to date, the substances responsible for malformations in the human species have been shown to be teratogenic in animals during well-conducted studies on two species.
  • In humans, there are no relevant clinical data from the use of SOLUVIT during pregnancy.
  • Therefore, SOLUVIT should only be administered to pregnant women if clearly needed.

Feeding with milk

  • The administration of SOLUVIT is not recommended in case of breast-feeding because of a risk of vitamin overdose in the newborn.

What happens if I overdose from soluvit ?

An overdose of water-soluble vitamins for parenteral use is not expected. No adverse effects related to overdose have been reported to date.

What should I do if I miss a dose?

COMPLY WITH LAVIS MEDICAL

What happens if you stop taking soluvit ?

  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.
  • Not applicable.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse for more information.

What is  Forms and Composition ?

SHAPES and PRESENTATIONS

  • Lyophilisate for parenteral use:   Bottles, box of 10.

COMPOSITION 

  p bottle
Thiamine (vitamin B1) 2.5 mg
(as mononitrate: 3.1 mg / vial)
Riboflavin (vitamin B2) 3.6 mg
(as sodium phosphate: 4.9 mg / vial)
Nicotinamide (vitamin PP or B3) 40 mg
Pyridoxine (vitamin B6) 4 mg
(as hydrochloride: 4.9 mg / vial)
Sodium pantothenate (vitamin B5) 16.5 mg
(as pantothenic acid: 15 mg / vial)
Ascorbic acid 100 mg
(as sodium ascorbate: 113 mg / vial)
Biotin 0.06 mg
Folic acid (vitamin B9) 0.4 mg
Cyanocobalamin (vitamin B12) 0.005 mg
  • Excipients: glycocoll, sodium edetate. Preservative: methyl parahydroxybenzoate (E218).
  • Excipient with known effect: methyl parahydroxybenzoate (E218).

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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Gelumaline Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1921/gelumaline.html https://edrug-online.com/1921/gelumaline.html#respond Tue, 29 Sep 2020 10:22:51 +0000 https://edrug-online.com/?p=1921 GELUMALINE (WITH PARACETAMOL), capsule, box of 16Generic drug of the therapeutic class: Analgesicsactive ingredients: Belladonna , Codeine , Caffeine , Paracetamol Drug withdrawn from the market on 24/11/2006  what is Gelumaline medication used for and indication? Symptomatic treatment of painful and febrile ailments : neuralgia, rheumatic pain, dental pain, migraines, painful periods. Gelumaline Dosage Adult : 1 to 2 capsules 1 to 3 times a day depending on the intensity and duration of the pain. […]]]> GELUMALINE (WITH PARACETAMOL), capsule, box of 16

Generic drug of the therapeutic class: Analgesics
active ingredients: Belladonna , Codeine , Caffeine , Paracetamol

Drug withdrawn from the market on 24/11/2006

 what is Gelumaline medication used for and indication?

Symptomatic treatment of painful and febrile ailments :

  • neuralgia,
  • rheumatic pain,
  • dental pain,
  • migraines,
  • painful periods.

Gelumaline Dosage

Adult :

  • 1 to 2 capsules 1 to 3 times a day depending on the intensity and duration of the pain.
  • Do not exceed 6 capsules per day.
  • The catches should be spaced at least 4 hours apart.

Gelumaline Contraindications

CONTRA-INDICATED:

  • Hypersensitivity to paracetamol.
  • Hepatocellular insufficiency.
  • Respiratory failure whatever the degree, due to the depressant effect of codeine on the respiratory centers.
  • Glaucoma by closing the angle.
  • Prostatic adenoma with urinary retention.
  • Child under 15 years old.
  • Breast-feeding: codeine passes into breast milk; a few cases of hypotonia and respiratory pauses have been described in infants after ingestion by mothers of codeine at supratherapeutic doses. Therefore, taking this drug is contraindicated during breast-feeding.

Contraindicated associations: morphine agonists-antagonists (buprenorphine, nalbuphine).

  • ADVISED AGAINST: Combinations
  • not recommended : enoxacin, alcohol.

Gelumaline Side Effects

  • Rare allergic skin reactions requiring discontinuation of treatment (paracetamol, codeine).
  • A few rare cases of thrombocytopenia have been cited in the international literature (paracetamol).
  • Possibility of constipation, somnolence, dizziness, nausea, vomiting, bronchospasm, respiratory depression (codeine: these adverse effects are comparable to those of other opiates but rarer and more moderate at therapeutic doses).
  • In high doses, adverse effects of atropine type, dry mouth, accommodation disorders, tachycardia, dysuria (belladonna powder).

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

]]>
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 Prontalgine tablet Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1899/prontalgine-tablet.html https://edrug-online.com/1899/prontalgine-tablet.html#respond Sat, 26 Sep 2020 21:56:15 +0000 https://edrug-online.com/?p=1899 PRONTALGINE, tablet,Generic drug of the therapeutic class: Analgesics active ingredients: Paracetamol + Codeine + Caffeine what is Prontalgine tablet medication used for and indication? Treatment in adults of pain of moderate to severe intensity or which is not relieved by aspirin or paracetamol alone. PRESENTATION (S) AVAILABLE FOR PRONTALGINE 5 presentations are available for this drug: […]]]> PRONTALGINE, tablet,

Generic drug of the therapeutic class: Analgesics
active ingredients: Paracetamol + Codeine + Caffeine

what is Prontalgine tablet medication used for and indication?

Treatment in adults of pain of moderate to severe intensity or which is not relieved by aspirin or paracetamol alone.

PRESENTATION (S) AVAILABLE FOR PRONTALGINE

5 presentations are available for this drug:

  • 2 blister (s) PVC aluminum of 5 tablet (s)
  • 2 blister pack (s) PVC aluminum of 6 tablet (s)
  • 2 PVC aluminum blister pack (s) of 18 tablet (s)
  • 4 blister pack (s) PVC aluminum of 5 tablet (s)
  • PVC aluminum blister pack (s) of 6 tablet (s)
FEATURE DESCRIPTION
Pharmaceutical class not communicated
Active substance (s) for one tablet: caffeine (50.0 mg), paracetamol (400.0 mg), codeine (phosphate) hemihydrate (20.0 mg)
General medicine no
Pharmaceutical form compressed
Route (s) of administration oral
Selling price unregulated price
Social security reimbursement rate 0%
Laboratory (s) Laboratory (s) manufacturer Prontalgine
Conditions of issue available by simple prescription

 

Prontalgine tablet Dosage

RESERVED FOR ADULTS.

1 tablet to be taken with a glass of water, to be renewed if necessary after 4 hours, possibly 2 tablets per dose in the event of severe pain, without exceeding 6 tablets per day.

THIS MEDICINE HAS BEEN DELIVERED TO YOU PERSONALLY IN A SPECIFIC SITUATION:

  • IT MAY NOT BE SUITABLE FOR ANOTHER CASE.
  • DO NOT ADVISE IT TO ANOTHER PERSON.

Prontalgine tablet Contraindications

 

How To Take Prontalgine tablet ?

Administration mode

Oral route.

Frequency of administration

  • Systematic catches prevent pain peaks.
  • They must be spaced at least 4 hours apart.
  • In the event of severe kidney disease (renal failure), the catches should be spaced at least 8 hours apart.

Duration of the treatment

  • If the pain persists for more than 5 days, consult your doctor.

how does Prontalgine tablet work?

Pharmacotherapeutic group: OTHER ANALGESICS AND ANTIPYRETICS, ATC code: N02BE51.

Association of three active ingredients:

  • · Paracetamol analgesic, antipyretic. Paracetamol has a central and peripheral mechanism of action,
  • · Codeine phosphate hemihydrate: central opioid analgesic,
  • · Caffeine: central stimulant.

The combination of paracetamol and codeine phosphate has an analgesic activity significantly greater than that of its components taken alone, with a more prolonged effect over time.

Codeine

  • Codeine is a weak centrally acting analgesic. It exerts its effect through its action on µ opioid receptors although its affinity for these receptors is low. Its analgesic effect is due to its conversion to morphine.
  • Codeine, in particular when it is combined with other analgesics such as paracetamol, has shown its effectiveness in the treatment of nociceptive pain.

How To Store Prontalgine tablet ?

  • Keep this medication out of the sight and reach of children.
  • Do not use PRONTALGINE, tablet after the expiry date stated on the box.
  • No special storage conditions.
  • Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

Prontalgine tablet Side Effects

Like all medicines, PRONTALGINE, tablet can cause side effects, although not everybody gets them.

Linked to the presence of paracetamol

  • A few rare hypersensitivity reactions such as anaphylactic shock, angioedema, erythema, urticaria, extensive skin rash have been reported. Their occurrence requires the definitive discontinuation of this drug and related drugs.
  • Very exceptional cases of decrease in platelets (important blood elements in blood clotting) have been reported.

Linked to the presence of codeine

Possibility of :

  • constipation, nausea, vomiting,
  • drowsiness, dizziness,
  • hypersensitivity reactions (pruritus, hives and, in rare cases, extensive rash),
  • respiratory problems,
  • abdominal pain especially in cholecystectomized patients (without gallbladder).

Linked to the presence of caffeine

  • Possibility of excitement, insomnia, palpitations.

If you notice any side effects not listed in this leaflet, or if any side effects get serious, please tell your doctor or pharmacist.

Keep out of the reach and sight of children.

Prontalgine tablet Interactions

RELATED TO PARACETAMOL

Combinations subject to precautions for use

Antivitamin K

  • Risk of an increase in the effect of the antivitamin K and of the risk of bleeding if paracetamol is taken at maximum doses (4 g / d) for at least 4 days.
  • More frequent control of the INR. Possible adjustment of the dose of the antivitamin K during treatment with paracetamol and after its discontinuation.

Interactions with paraclinical examinations

  • Taking paracetamol can falsify the determination of blood glucose by the glucose oxidase-peroxidase method in the event of abnormally high concentrations.
  • Taking paracetamol can interfere with the dosage of uric acid in the blood by the phosphotungstic acid method.

RELATED TO CODEINE

Not recommended associations

Alcohol

  • Alcohol enhancement of the sedative effect of codeine.
  • Impaired vigilance can make driving and using machines dangerous.
  • Avoid taking alcoholic drinks or drugs containing alcohol.

Morphinic agonist-antagonists: buprenorphine, nalbuphine, pentazocine.

  • Decrease in the analgesic effect by competitive blocking of receptors, with the risk of the appearance of a withdrawal syndrome.

Partial antagonist morphines

  • Risk of reduction of the analgesic effect.

Associations to take into account

Barbiturates, benzodiazepines, other morphine derivatives (analgesics, cough suppressants and substitution treatments)

  • Increased risk of respiratory depression which may be fatal in case of overdose.

+ Other CNS depressants: sedative antidepressants, sedating H1 antihistamines, barbiturates, clonidine and related drugs, hypnotics, neuroleptics, anxiolytics.

  • Increase in central depression.
  • Impaired vigilance can make driving and using machines dangerous.
  • Not applicable.

Effects on ability to Drive and use machines

  • Attention is drawn especially among vehicle drivers and machine users to the risks of drowsiness due to the presence of codeine in this medication. 
  • This phenomenon subsides after several intakes, it may be useful to start this treatment in the evening. 
  • This phenomenon is accentuated by the consumption of alcoholic beverages.

Warnings and Precautions

Special warnings

To avoid a risk of overdose:

  • · Check for codeine and paracetamol in the composition of other medications, including whether they are medicines obtained without a prescription,
  • · Respect the maximum recommended doses (see Dosage and Administration).
  • Prolonged use of codeine can lead to a state of dependence.
  • Deafferentation pain (neurogenic pain) does not respond to the codeine paracetamol combination.
  • As part of the management of pain in children, the administration of codeine requires a medical prescription .
  • Monitoring should focus on the vigilance of the child: before taking this medication, make sure that the child does not have an excessive or abnormal tendency to drowsiness.

Precautions for use

Elderly: reduce the initial dosage by half of the recommended dosage, and possibly increase it secondarily depending on tolerance and needs (see section Dosage and method of administration).

Related to paracetamol:

Paracetamol should be used with caution in the following cases:

  • · Weight <50 kg
  • · Mild hepatic insufficiency to moderate
  • · Severe renal impairment (creatinine clearance ≤ 30 ml / min (see sections Dosage and administration and Pharmacokinetic properties)),
  • · Chronic alcoholism,
  • · Chronic malnutrition (low reserves of hepatic glutathione)
  • · Dehydration (see Dosage and Administration).

If acute viral hepatitis is found, treatment should be stopped.

Related to codeine:

  • Alcohol absorption during treatment is not recommended due to the presence of codeine.
  • In the event of intracranial hypertension, codeine may increase the extent of this hypertension.
  • In productive coughs, codeine can interfere with sputum.
  • In cholecystectomized patients, codeine can cause an acute abdominal pain syndrome of the biliary or pancreatic type, most often associated with laboratory abnormalities, suggestive of a spasm of the sphincter of Oddi.

CYP2D6 metabolism:

  • Codeine is metabolized to morphine by the liver enzyme CYP2D6, its active metabolite. In the event of a deficiency or absence of this enzyme, the expected analgesic effect will not be obtained.
  • It is estimated that up to 7% of the Caucasian population may have this deficit.
  • However, if the patient is a rapid or ultra-rapid metabolizer, there is an increased risk, even at therapeutic doses, of developing adverse effects due to opioid toxicity. These patients convert codeine to morphine rapidly, therefore their serum morphine level is higher than expected.
  • General symptoms of opioid toxicity include confusion, drowsiness, shallow breathing, miosis, nausea, vomiting, constipation, and lack of appetite. In severe cases, patients may present with symptoms of respiratory and circulatory depression, which can be life-threatening and very rarely be fatal.

The estimated prevalences of ultrafast metabolizers in the different populations are summarized below:

Population Prevalence%
Africans / Ethiopians 29%
African Americans 3.4% to 6.5%
Asians 1.2% to 2%
Caucasians 3.6% to 6.5%
Greeks 6.0%
Hungarian 1.9%
Northern Europeans 1 to 2%

Post-operative use in children

  • Cases published in the literature have shown that codeine, used postoperatively in children after tonsillectomy and / or adenoidectomy in the context of obstructive sleep apnea syndrome, causes rare side effects but may cause game the vital prognosis or even lead to death (see section Contraindications). All of these children had received codeine at the recommended doses; however, there was evidence that these children were rapid or ultra-rapid metabolisers of codeine into morphine.

Children with impaired respiratory function

  • Codeine is not recommended in children who may have impaired respiratory function due to neuromuscular disorders, severe cardiac or respiratory disorders, upper respiratory or pulmonary infections, multiple trauma or lengthy surgical procedures. These factors can worsen the symptoms of morphine toxicity.

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • Using point of this drug can be considered during pregnancy, if it is necessary from a clinical point of view. However, it should be used at the lowest effective dose, for the shortest possible time and at the lowest possible frequency. Its chronic use should be avoided.
  • In the event of administration at the end of pregnancy, take into account the morphino-mimetic properties of this drug (theoretical risk of respiratory depression in the newborn after high doses before childbirth, risk of withdrawal syndrome in the event of administration chronic in late pregnancy).

Linked to paracetamol:

  • A large amount of data on pregnant women demonstrate the absence of any malformations or fetal / neonatal toxicity. Epidemiological studies devoted to the neurodevelopment of children exposed to paracetamol in utero produce inconclusive results.

Linked to codeine:

  • Clinically, although a few case-control studies show an increased risk of heart defects occurring, most epidemiological studies rule out a malformation risk.
  • Studies in animals have shown a teratogenic effect.

Feeding with milk

This medication is contraindicated during breast-feeding (see section Contraindications):

  • Paracetamol and codeine pass into breast milk.
  • The action to be taken during breastfeeding depends on the presence of codeine.
  • At normal therapeutic doses, codeine and its active metabolite may be present in breast milk at very low doses and is unlikely to cause adverse effects in the nursing infant. However, if the patient is an ultra-rapid CYP2D6 metabolizer, a significant amount of the active metabolite, morphine, may be present in maternal blood as well as in breast milk. In very rare cases, these elevated levels can cause symptoms of opioid toxicity in children (drowsiness, difficulty sucking, pauses or even respiratory depression and hypotonia) which can be fatal.

Fertility

Linked to paracetamol:

  • Due to the potential mechanism of action on cyclooxygenase and the synthesis of prostaglandins, paracetamol could impair fertility in women, through an effect on ovulation which is reversible upon discontinuation of treatment.
  • Effects on male fertility have been observed in an animal study. The relevance of these effects in humans is not known.

Linked to codeine:

  • There are no data in animals regarding male and female fertility.

What happens if I overdose from Prontalgine tablet ?

OVERDOSAGE WITH PARACETAMOL:

  • The risk of serious intoxication (therapeutic overdose or accidental intoxication) may be particularly high in the elderly, in young children, in patients with liver damage, in chronic alcoholism, in patients suffering from chronic malnutrition. .
  • In these cases, poisoning can be fatal.

Symptoms

  • Nausea, vomiting, anorexia, pallor, abdominal pain usually appear within the first 24 hours.
  • An overdose, starting from 10 g of paracetamol in a single dose in adults and 150 mg / kg of body weight in a single dose in children, causes hepatic cytolysis which may lead to complete and irreversible necrosis. resulting in hepatocellular insufficiency, metabolic acidosis, encephalopathy which can lead to coma and death.
  • At the same time, there is an increase in hepatic transaminases, lactico-dehydrogenase, bilirubin and a decrease in the level of prothrombin which may appear 12 to 48 hours after ingestion.
  • Emergency driving
  • · Stop the treatment.
  • · Immediate transfer to hospital.
  • · Take a tube of blood plasma to the initial dosage of paracetamol.
  • · Rapid evacuation of the ingested product, by gastric lavage.
  • · Treatment of overdose typically includes administration as early as possible of the antidote N-acetylcysteine intravenously or orally if possible before the tenth hour.
  • · Symptomatic treatment.

CODEINE OVERDOSAGE

Signs in adults:

  • · Acute depression of the respiratory centers (cyanosis, respiratory slowing), drowsiness, rash, vomiting, itching, ataxia, pulmonary edema (rare).

Signs in children (toxic threshold: 2 mg / kg as a single dose):

  • · Slowing of respiratory rate, pauses in breathing, miosis, convulsions, signs of histaminoliberation: “facial puffiness”, urticarial rash, collapse, urinary retention.

Emergency driving:

  • · Stop the treatment.
  • · Respiratory assistance.
  • · Administration of naloxone.

What should I do if I miss a dose?

If you forget to take PRONTALGINE, tablet

  • Do not take a double dose to make up for the single dose you forgot to take. Continue treatment as prescribed.

What happens if you stop taking Prontalgine tablet ?

Effects which may appear when treatment with PRONTALGINE, tablet is stopped:

  • With prolonged treatment, suddenly stopping this medication may lead to withdrawal syndrome.

What is  Forms and Composition ?

SHAPES and PRESENTATIONS

  • Tablet (white):   Box of 18, in blister packs.

Other shapes

  • PRONTALGINE, tablet, box of 12

COMPOSITION

  p cp
Paracetamol *  (INN)  400 mg
Anhydrous caffeine  50 mg
Codeine phosphate hemihydrate  20 mg
(corresponding amount of codeine: 15.6 mg / tab)
  • Excipients: crospovidone, sodium carboxymethyl starch, colloidal anhydrous silica, magnesium stearate, povidone, microcrystalline cellulose.
  • *  in the form of granulated paracetamol with povidone (paracetamol titer: 94.5 to 97.5%).
  • The quantity used is adjusted according to the title.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
]]>
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CERNEVIT Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/1596/cernevit.html https://edrug-online.com/1596/cernevit.html#respond Thu, 03 Sep 2020 10:21:13 +0000 https://edrug-online.com/?p=1596 cernevitGeneric Drug Class Drug: Anesthesia, resuscitation, analgesic active ingredients: retinol , cholecalciferol , Alpha-tocopherol (E307) , ascorbic acid (E300) , Thiamine , Riboflavin (E101) , Pyridoxine , Cyanocobalamin , Folic Acid , Pantothenic Acid , Biotin , Nicotinamide what is CERNEVIT ? CERNEVIT is a balanced mixture of water-soluble (water-soluble) and fat-soluble (fat-soluble) vitamins allowing vitamin supplementation, during parenteral nutrition for adults and children over 11 years old. PRESENTATION (S) AVAILABLE FOR CERNEVIT 6 presentations are available for this […]]]> cernevit

Generic Drug Class Drug: Anesthesia, resuscitation, analgesic
active ingredients: retinol , cholecalciferol , Alpha-tocopherol (E307) , ascorbic acid (E300) , Thiamine , Riboflavin (E101) , Pyridoxine , Cyanocobalamin , Folic Acid , Pantothenic Acid , Biotin , Nicotinamide

what is CERNEVIT ?

CERNEVIT is a balanced mixture of water-soluble (water-soluble) and fat-soluble (fat-soluble) vitamins allowing vitamin supplementation, during parenteral nutrition for adults and children over 11 years old.

PRESENTATION (S) AVAILABLE FOR CERNEVIT

6 presentations are available for this medication:

  • 1 amber glass vial (s)
  • 1 amber glass vial (s) with transfer device (s)
  • 10 amber glass vial (s)
  • 10 amber glass vial (s) with transfer device (s)
  • 20 amber glass bottle (s)
  • 20 amber glass vial (s) with transfer device (s)
FEATURE DESCRIPTION
Pharmaceutical class blood derivatives and various infusions
Active substance (s) for 1 vial of 5 ml: biotin (0.069 mg), riboflavin sodium phosphate dihydrate (5.67 mg), alpha-tocopherol (11.200 IU), ascorbic acid (125 mg), folic acid (0.414 mg), cholecalciferol (220 IU), cyanocobalamin (0.006 mg), dexpanthenol (16.15 mg), nicotinamide (46 mg), pyridoxine hydrochloride (5.5 mg), retinol palmitate, cocarboxylase tetrahydrate (5.8 mg)
General medicine no
Pharmaceutical form powder for solution for injection or infusion
Route (s) of administration intravenous
Social security reimbursement rate 65%
Laboratory (s) BAXTER SA
Conditions of issue available by simple prescription

CERNEVIT Dosage

Dosage

  • The usual daily dose is one 5 ml vial.

Administration mode

  • Strict intravenous use.
  • After reconstitution, administer by slow intravenous injection (at least ten minutes) or by infusion in 5% glucose or 0.9% sodium chloride solution.
  • CERNEVIT can be used in the composition of nutrient mixtures, combining carbohydrates, lipids, amino acids, electrolytes, provided that the compatibility and stability have been checked beforehand in the case of each nutrient mixture used.

Reconstitution technique

CERNEVIT (bottle without BIO-SET)

  • Using a syringe, inject 5 ml of water for injections or 5% glucose or 0.9% sodium chloride solution into the vial.
  • Shake lightly to dissolve the powder.
  • The solution obtained is yellow-orange in color.

CERNEVIT BIO-SET

CERNEVIT BIO-SET allows direct reconstitution in the bags (single or multi-compartment plastic bags) including a supplementation site.

Single pocket:

  1. Remove the cap by turning it then pulling it to break the safety ring.
  2. Directly connect the BIO-SET to the supplementation site of the bag
  3. Apply pressure on the transparent mobile part of the BIO-SET to puncture the rubber stopper of the bottle.
  4. Hold the connected system (CERNEVIT BIO-SET / infusion bag) in a vertical position, with the bag on top. Gently squeeze the infusion bag several times to transfer solution to the vial (approximately 5 ml). Shake the vial to dissolve CERNEVIT.
  5. Turn the connected system over, holding it vertically with the pocket at the bottom. Gently squeeze the infusion bag several times to force air from the top of the bag into the vial, allowing the solution to return to the infusion bag
  6. Repeat instructions 4 and 5 until the bottle is empty.
  7. Remove the CERNEVIT BIO-SET vial and throw it away.
  8. Mix gently

Multi-compartment pocket:

The reconstitution of CERNEVIT BIO-SET must be carried out before reconstitution of the multi-compartment bag (before opening the non-permanent seals and before mixing the contents of the compartments)

  1. Place the multi-compartment pocket on a work surface.
  2. Remove the CERNEVIT BIO-SET cap by turning it then pulling it to break the safety ring.
  3. Directly connect the BIO-SET to the supplementation site of the multi-compartment bag
  4. Apply pressure on the transparent mobile part of the BIO-SET to puncture the rubber stopper of the bottle.
  5. Hold the vial vertically with the upper part up. Gently squeeze the compartment several times to transfer solution to the vial (approximately 5 ml). Shake the vial to dissolve CERNEVIT.
  6. Turn the connected system over, holding the vial vertically upside down. Gently squeeze the compartment several times to pass air from the top of the compartment into the vial allowing the solution to return to the infusion bag
  7. Repeat steps 5 and 6 until the vial is empty.
  8. Remove the CERNEVIT BIO-SET vial and discard it.
  9. Finally, reconstitute the multi-compartment pocket
  10. Mix by inverting the bag at least 3 times

Warning :

  • Take care that the BIO-SET does not disconnect from the supplementation site during the entire reconstitution process.

Frequency of administration and duration of treatment

  • Administration can be continued for the duration of parenteral nutrition.
  • Comply with medical advice.

CERNEVIT Contraindications

CERNEVIT should not be used:

  • In case of hypersensitivity to the active ingredients, in particular to vitamin B1 or to excipients.
  • In newborns, infants and children under 11 years old.

how does CERNEVIT work?

Pharmacotherapeutic group: ADDITIVES FOR INTRAVENOUS SOLUTIONS / VITAMINS

ATC code: B05XC

(B: Blood and hematopoietic organs)

CERNEVIT is a balanced combination of water-soluble and fat-soluble vitamins covering daily needs during parenteral nutrition.

The pharmacodynamic properties of CERNEVIT are those of each of the 12 vitamins included in its composition. The main properties are as follows:

  1. Vitamin A : Involved in the processes of cell growth and differentiation, and in the physiological mechanisms of vision.
  2. Vitamin D : Regulation of the metabolism of calcium and phosphorus in the bones and kidneys.
  3. Vitamin E : Antioxidant properties preventing the formation of toxic oxidation products and protecting cellular constituents.
  4. Vitamin B 1 : (thiamine) In association with ATP, formation of a coenzyme involved in the metabolism of carbohydrates.
  5. Vitamin B 2 : (riboflavin) Coenzyme action in cellular energy metabolism, tissue respiration systems and macronutrient metabolism.
  6. Vitamin B 3 : (PP) Component of the NAD and NADP coenzymes involved in redox reactions essential for macronutrient metabolism and tissue respiration.
  7. Vitamin B 5 : (pantothenic acid) Precursor of coenzyme A involved in the oxidative metabolism of carbohydrates, gluconeogenesis and the synthesis of fatty acids, sterols, steroid hormones and porphyrins.
  8. Vitamin B 6 : (pyridoxine) Coenzyme in the metabolism of proteins, carbohydrates and fats.
  9. Vitamin B 12 : Exogenous source necessary for the synthesis of nucleoproteins and myelin, cell reproduction, growth and maintenance of normal erythropoiesis.
  10. Vitamin C : Antioxidant properties, essential for the formation and maintenance of intercellular substances and collagen, the biosynthesis of catecholamines, the synthesis of carnitine and steroids, the metabolism of folic acid and tyrosine.
  11. Folic acid : An exogenous source necessary for the synthesis of nucleoproteins and the maintenance of normal erythropoiesis.
  12. Biotin : Linked to at least four enzymes, involved in energy metabolism including gluconeogenesis.

How To Store CERNEVIT ?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiration date refers to the last day of that month.
  • Store at a temperature not exceeding 25 ° C.
  • Store the vial in the outer carton.
  • After reconstitution, physico-chemical stability has been demonstrated for 24 hours at 25 ° C. From a microbiological point of view, the product should be used immediately after reconstitution. If not used immediately, storage time and conditions after reconstitution and before use are the sole responsibility of the user and should not normally exceed 24 hours at 2 ° C to 8 ° C, unless reconstitution has taken place in controlled and validated asepsis conditions.
  • Do not throw away any medicine at all or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

CERNEVIT Side Effects

Adverse reactions occurring after administration of CERNEVIT are presented by their relative frequency; these include adverse reactions documented in clinical trials and those reported post-marketing. The frequencies of adverse reactions are described using the following convention: very common (≥ 1/10); common (≥ 1/100, <1/10); uncommon (≥ 1 / 1,000, <1/100); rare (≥ 1 / 10,000, <1 / 1,000); very rare (<1 / 10,000); and not known (cannot be estimated from the available data).

Adverse reactions related to CERNEVIT, reported in clinical trials and after marketing:

System organ class MedDRA preferred term Frequency
Immune system disorders Hypersensitivity reactions manifested by chest discomfort, rash, urticaria, erythema, anaphylactic shock indeterminate
Hepatobiliary disorders Increased liver enzymes (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, alkaline phosphatase) indeterminate

Hypersensitivity reactions to the components of CERNEVIT are mainly due to allergic reactions to vitamin B1. Their intensity can vary from moderate to severe.

CERNEVIT Interactions

Use of other drugs

  • Due to the presence of pyridoxine in CERNEVIT, the combination with levodopa requires precautions for use.
  • Due to the presence of folic acid in CERNEVIT, the combination with anticonvulsant drugs containing phenobarbital, phenytoin, or primidone requires precautions for use.
  • If you are taking or have recently taken any other medicines, including medicines obtained without a prescription, talk to your doctor or pharmacist.

Drive and use machines

  • There is no information available on the effects of CERNEVIT on the ability to drive and use machines.
  • CERNEVIT contains soya lecithin as an excipient.

Warnings and Precautions

Special warnings

Hypersensitivity reactions

  • Systemic hypersensitivity reactions to constituents of CERNEVIT, mild to severe, have been reported (including vitamins B1, B2, B12, folic acid and soy lecithin) (see Adverse Effects).
  • Allergic cross reactions between soybean and peanut proteins have been observed.
  • The infusion or injection should be stopped immediately if signs or symptoms of a hypersensitivity reaction develop.

Vitamin toxicity

  • The patient’s clinical condition and blood levels of vitamins should be closely monitored to avoid overdose and toxic effects, especially vitamins A, D and E and especially in patients receiving vitamin supplementation from other sources or that use other agents that increase the risk of vitamin toxicity.
  • Monitoring is particularly important in patients receiving long-term supplementation.

Hypervitaminosis A:

  • The risk of hypervitaminosis A and toxicity of vitamin A (eg., Abnormalities of skin and bones, diplopia, cirrhosis) is increased, for example, in patients with protein malnutrition, kidney failure (even lack of vitamin A supplementation), hepatic insufficiency, short stature (eg, pediatric population) and in patients on chronic treatment.
  • An acute liver disease in patients with liver stores of vitamin A saturated may lead to the manifestation of toxicity of vitamin A.

Hypervitaminosis D:

  • Excessive vitamin D intake can cause hypercalcemia and hypercalciuria.
  • The vitamin D toxicity risk is increased in patients with a disease and / or disorders causing hypercalcemia and / or hypercalciuria, or in chronic vitamin treatment in patients.

Hypervitaminosis E:

  • Although very rare, excessive doses of vitamin E can lead to slow healing due to platelet dysfunction and blood clotting abnormalities.
  • The risk of vitamin E toxicity is increased in patients with hepatic impairment, a bleeding disorder or treated with oral anticoagulants or with vitamin treatment on chronic patients.

Precautions for use

Liver effects:

  • Monitoring of liver function parameters is recommended in patients receiving CERNEVIT. Particularly close monitoring is recommended in patients with hepatic jaundice or other signs of cholestasis.
  • Elevations of liver enzymes have been reported in patients receiving CERNEVIT including isolated cases of increased alanine aminotransferase (ALT) levels in patients with inflammatory bowel disease (see Adverse effects).
  • In addition, increased bile acid levels (individual and total bile acids, glycocholic acid) have been reported in patients receiving CERNEVIT.
  • Due to the presence of glycocholic acid, repeated and prolonged administration in patients with significant hepatic jaundice or cholestasis biochemically requires attentive monitoring of liver function.
  • Disorders of the Hepatobiliary cholestasis, hepatic steatosis, fibrosis and cirrhosis, which can lead to liver failure, as well as cholecystitis and biliary stones are known to develop in some patients on parenteral nutrition (particularly during parenteral nutrition supplemented with vitamin ). The etiology of these disorders is considered to be multifactorial and may vary depending on the patient. Patients who develop abnormal laboratory parameters or other signs of hepatobiliary disorders should be evaluated promptly by a hepatic disease physician to identify possible causes and factors as well as possible therapeutic and prophylactic interventions.

Use in patients with impaired liver function

  • Patients with liver problems may require individualized vitamin supplementation.
  • Particular attention should be paid to preventing vitamin A toxicity as the presence of liver disease is associated with increased susceptibility to vitamin A toxicity, especially in association with excessive alcohol consumption. and chronic (see also hypervitaminosis A and hepatic effects above).

Use in patients with impaired renal function

  • Patients with impaired renal function may require individualized vitamin supplementation, depending on the degree of renal impairment and the presence of a concomitant medical condition. In patients with severe renal impairment, special care should be taken to maintain adequate vitamin D levels and to prevent any toxicity from vitamin A.

General surveillance

  • The total amounts of vitamins from all sources, such as nutritional sources, other vitamin supplements, or medicinal products containing vitamins as excipients (see section Interactions with other medicinal products and other forms of interaction) should be taken into account. .
  • The patient’s clinical condition and vitamin levels should be monitored to ensure that appropriate levels are maintained.
  • The sensitivity of some vitamins, especially vitamins A, B2 and B6, to ultraviolet rays (eg, direct or indirect sunlight) should be taken into account. In addition, losses of vitamins A, B1, C and E can increase with high oxygen levels in the solution. These factors should be considered if adequate vitamin levels are not achieved.
  • Patients receiving parenteral multivitamin solutions as the sole source of vitamins for an extended period of time should be monitored to verify the adequacy of supplementation, including:
    • Vitamin A in patients with pressure ulcers, wounds, burns, a short gut syndrome or cystic fibrosis
    • Vitamin B1 in dialysis patients
    •  Vitamin B2 in patients with cancer
    •  Vitamin B6 in patients with renal impairment
    • The vitamins individual requirements may be increased due to interactions with other drugs (see Interactions with other drugs and other forms of interaction).
  • A deficiency in one or more vitamins must be corrected by specific supplementation.
  • CERNEVIT does not contain vitamin K, this should be administered separately if necessary.
  • Use in patients with vitamin B12 deficiency.
  • Assessment of vitamin B12 levels is recommended before starting supplementation with CERNEVIT in patients at risk of vitamin B12 deficiency and / or when supplementation is planned over several weeks.
  • After several days of treatment, the individual amounts of cyanocobalamin (vitamin B12) and folic acid contained in CERNEVIT may be sufficient to cause an increase in the number of red blood cells, reticulocytes, and hemoglobin values ​​in some patients with megaloblastic anemia associated with vitamin B12 deficiency. This may mask an existing vitamin B12 deficiency which requires greater intakes of cyanocobalamin than those provided by CERNEVIT.
  • When interpreting vitamin B12 levels, the possibility that recent vitamin B12 intakes may lead to normal levels, despite tissue deficiency, should be taken into account.

Interactions with laboratory tests

  • Biotin can interfere with lab tests based on a biotin / streptavidin interaction, causing either a false decrease or a false increase in results, depending on the test. The risk of interference is higher in children and patients with renal impairment and increases with higher doses. When interpreting the results of laboratory tests, consideration should be given to possible biotin interferences, especially if inconsistency with the clinical picture is observed (for example, results of thyroid tests mimicking the Graves’ disease in asymptomatic patients taking biotin or false negative troponin test results in patients with myocardial infarction taking biotin). Alternative tests not susceptible to biotin interference should be used, if available, in cases where interference is suspected. Laboratory personnel should be consulted when ordering laboratory tests in patients taking biotin.

Ascorbic acid may interfere with the blood and urine glucose control systems (see section Interactions with other medicines and other forms of interactions)

Geriatric use

  • In general, dose adjustments in elderly patients should be considered (dose reduction and / or dose interval prolongation) due to the greater susceptibility of these patients to have impaired hepatic, renal or cardiac function, concomitant pathologies and drug treatments.

Sodium content

  • CERNEVIT contains 24 mg sodium (1 mmol) per vial. This should be taken into account if patients are on a controlled sodium diet.
  • Compatibility must be tested before mixing with other solutions for infusion and, in particular, when adding CERNEVIT to bags of binary mixtures of parenteral nutrition, combining glucose, electrolytes and a solution of amino acids, as well as ternary mixtures combining glucose, electrolytes, a solution of amino acids and lipids (see sections Incompatibilities and Instructions for use, handling and disposal).

PREGNANCY & BREAST-FEEDING & FERTILITY

Pregnancy

  • CERNEVIT can be prescribed during pregnancy if necessary, in accordance with the indication and dosages in order to avoid vitamin overdose.
  • Ask your doctor or pharmacist for advice before taking any medicine.

Feeding with milk

  • The use of CERNEVIT is not recommended during breast-feeding because of the risk of overdose of vitamin A in the newborn.
  • Ask your doctor or pharmacist for advice before taking any medicine.

What happens if I overdose from CERNEVIT ?

  • Acute or chronic overdose of vitamins (especially A, B6, D and E) can cause symptomatic hypervitaminosis.
  • The risk of overdose is particularly high if the patient is receiving multiple sources of vitamins and the overall vitamin supplementation does not match the patient’s individual needs; as well as in patients with increased sensitivity to hypervitaminosis .
  • The signs resulting from an overdose of CERNEVIT are mainly those resulting from the administration of excessive doses of vitamin A.

Clinical signs of acute A overdose (doses greater than 150,000 IU):

  • Digestive disorders, headache, intracranial hypertension, papillary edema, psychiatric disorders, irritability, even convulsions, delayed generalized desquamation.

Clinical signs of chronic intoxication (prolonged intake of vitamin A at supra-physiological doses in a non-deficient subject):

  • Intracranial hypertension, cortical hyperostosis of long bones and early epiphyseal fusion. The diagnosis is generally made on the observation of tender or painful subcutaneous swelling in the extremities of the limbs. X-rays show a thickening of the periosteum on the diaphyseal area of ​​the ulna, fibula, collarbones and ribs.

Clinical signs of neurotoxic effects:

  • Hypervitaminosis and toxicity (peripheral neuropathy, involuntary movements) of pyridoxine (vitamin B6) have been reported in patients receiving high doses for a prolonged period, and in chronic hemodialysis patients receiving polyvitamins, intravenously, containing 4 mg of pyridoxine, administered three times per week.

What to do in the event of acute or chronic overdose:

  • Treatment of an overdose of CERNEVIT consists of stopping the administration of CERNEVIT, and taking additional measures according to the patient’s clinical condition, such as reduction of calcium intake, increased diuresis and rehydration. .

What should I do if I miss a dose?

  • Not applicable.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse for more information.

What happens if you stop taking CERNEVIT ?

  • Not applicable.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse for more information.

What is  Forms and Composition ?

Appearance and shape

  • Powder for solution for injection or infusion.
  • Orange-yellow freeze-dried cake.

Powder in vial (type I amber glass); box of 1, 10 or 20.

Not all presentations may be marketed.

CERNEVIT: COMPOSITION

Active substances

A 5 ml vial contains:

  • Retinol (Vitamin A): 3500 IU

As retinol palmitate

  • Cholecalciferol (Vitamin D3): 220 IU
  • Alpha-tocopherol (Vitamin E): 11,200 IU
  • Quantity corresponding to LD alpha-tocopherol: 10.200 mg
  • Ascorbic acid (Vitamin C): 125,000 mg
  • Thiamine (Vitamin B1): 3,510 mg
  • In the form of cocarboxylase tetrahydrate: 5.800 mg
  • Riboflavin (Vitamin B2): 4,140 mg
  • As riboflavin sodium phosphate dihydrate: 5.670 mg
  • Pyridoxine (Vitamin B6): 4,530 mg
  • As pyridoxine hydrochloride: 5,500 mg
  • Cyanocobalamin (Vitamin B12): 0.006 mg
  • Folic acid (Vitamin B9): 0.414 mg
  • Pantothenic acid (Vitamin B5): 17,250 mg
  • In the form of dexpanthenol: 16,150 mg
  • Biotin (Vitamin B8): 0.069 mg
  • Nicotinamide (Vitamin PP): 46,000 mg

Other components

  • Glycine, glycocholic acid, soy lecithin, sodium hydroxide, hydrochloric acid.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
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spasfon tablet Drug Uses, Dosage, Side Effects, Precautions & Warnings https://edrug-online.com/75/spasfon-tablet.html https://edrug-online.com/75/spasfon-tablet.html#respond Thu, 03 Sep 2020 08:53:26 +0000 http://www.edrug-online.com/?p=75 what is spasfonspasfon tablet Drug >>> Generic drug of the Therapeutic class: Analgesics active ingredients: Phloroglucinol What is Spasfon used for and indication? · Symptomatic treatment of pain related to functional disorders of the digestive tract and bile ducts. · Treatment of acute spasmodic and painful urinary tract manifestations: renal colic. · Symptomatic treatment of painful spasmodic manifestations in gynecology. · Adjuvant treatment […]]]> what is spasfon

spasfon tablet Drug >>> Generic drug of the Therapeutic class: Analgesics
active ingredients: Phloroglucinol

What is Spasfon used for and indication?

  1. · Symptomatic treatment of pain related to functional disorders of the digestive tract and bile ducts.
  2. · Treatment of acute spasmodic and painful urinary tract manifestations: renal colic.
  3. · Symptomatic treatment of painful spasmodic manifestations in gynecology.
  4. · Adjuvant treatment of contractions during pregnancy in combination with rest.

spasfon dosage per day

6 tablets coated in 24 hours.

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients.

How it works SPASFON

ANTISPASMODIC MUSCULOTROPE

(A: digestive tract and metabolism)

(G: genitourinary system)

Phloroglucinol relieves spasm of smooth muscle fibers and calms pain.

HOW TO STORE SP ASFON, coated tablet?

  • Keep this medication out of the sight and reach of children.
  • Do not use this medicine after the expiry date stated on the box. The expiration date refers to the last day of that month.
  • Store at a temperature not exceeding 30 ° C.
  • Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

spasfon tablet side effects

Cutaneous and mucous manifestations: rash, rarely urticaria, exceptionally angioedema, hypotension, anaphylactic shock.

Interactions

Not applicable.

Warnings and Precautions

The combination of phloroglucinol with major analgesics such as morphine or its derivatives should be avoided because of their spasmogenic effect.

spasfon tablet uses in pregnancy / BREAST FEEDING / FERTILITY

What is the use of Spasfon tablet in pregnancy?

  • Studies in animals have not shown any teratogenic effect of phloroglucinol. In the absence of teratogenic effect in animals, a malformative effect in the human species is not expected. Indeed, to date, the substances responsible for malformations in the human species have proved teratogenic in animals in well conducted studies on two species.
  • In clinical practice, the relatively widespread use of phloroglucinol has apparently not revealed any malformation risk to date. However, epidemiological studies are needed to verify the absence of risk.
  • Therefore, the use of phloroglucinol should be considered during pregnancy only if necessary.

spasfon tablet uses in Breastfeeding

  • In the absence of data, it is advisable to avoid the use of this drug during breastfeeding.

spasfon tablet uses in feeding

  • In the absence of data, it is advisable to avoid the use of this drug during breastfeeding.

If you forget to take SPASFON, coated tablet

  • Do not take a double dose to make up for the dose you forgot to take.

What happens if I overdose from SPASFON ?

What is  Forms and Composition?

By lyophilisate at 80 mg:  
Phloroglucinol hydrate 80 mg
(in anhydrous phloroglucinol: 62.25 mg / lyoph)
By lyophilisate at 160 mg:  
Phloroglucinol dihydrate 160mg
(in anhydrous phloroglucinol: 124.466 mg / lyoph)
  • Excipients (common): dextran 70, mannitol; lyophilisate 160 mg: sucralose, macrogol 15-hydroxystearate.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

  • Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

  • General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

  • For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

  • It treats possible side effects and drug interactions that require attention and its effect on continuous use.
  • The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.
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